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Serum concentration of lidocaine after transversus abdominis plane block

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Abstract

We measured the serum concentration of lidocaine after transversus abdominis plane (TAP) block with 40 ml of 1% lidocaine in 12 patients under general anesthesia, using a fluorescence polarization immunoassay. The peak mean serum concentration of lidocaine occurred 30 min after the block (3.6 ± 0.7 μg·ml−1). The highest concentration of lidocaine (5.5 μg·ml−1) was recorded 15 min after the block. These results indicate that a TAP block can potentially cause systemic toxicity of a local anesthetic. The analgesic effect of the TAP block may partially depend on the rise in serum concentration of the local anesthetic.

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Authors and Affiliations

  1. Department of Anesthesiology, Aichi Gakuin University School of Dentistry, Aichi, Japan

    Naoko Kato & Jun Harada

  2. Department of Anesthesiology, Aichi Medical University School of Medicine, 21 Yazako, Nagakute, Aichi, 480-1195, Japan

    Yoshihiro Fujiwara, Misako Harato, Shuji Kurokawa, Yasuyuki Shibata & Toru Komatsu

Authors
  1. Naoko Kato
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  2. Yoshihiro Fujiwara
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  3. Misako Harato
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  4. Shuji Kurokawa
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  5. Yasuyuki Shibata
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  6. Jun Harada
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  7. Toru Komatsu
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Kato, N., Fujiwara, Y., Harato, M. et al. Serum concentration of lidocaine after transversus abdominis plane block. J Anesth 23, 298–300 (2009). https://doi.org/10.1007/s00540-008-0721-4

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  • DOI: https://doi.org/10.1007/s00540-008-0721-4

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