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Landiolol has a less potent negative inotropic effect than esmolol in isolated rabbit hearts

Journal of Anesthesia volume 22, pages 361–366 (2008)Cite this article

Abstract

Purpose

We compared the negative chronotropic and inotropic effects of landiolol and esmolol, two clinically available short-acting β1-blockers with high β1-selectivity, using whole isolated rabbit heart preparations.

Methods

Tachycardia was induced by continuous perfusion of 10−7 M isoproterenol, and we used concentrations of landiolol or esmolol in ascending steps (1 · 10−6, 3 · 10−6, 1 · 10−5, 3 · 10−5, and 1 · 10−4 M). Heart rate (HR), left ventricular developed pressure (LVDP), the maximal rates of left ventricular force development (LVdP/dtmax), and myocardial oxygen consumption (MVO2) were measured and compared.

Results

Both landiolol and esmolol produced dosedependent decreases in HR, LVDP, LVdP/dtmax, and MVO2. The HR lowering effects of the two agents were comparable. At concentrations of 3 · 10−5 and 1 · 10−4 M, esmolol produced more profound depression of LVDP (47 ± 26 and 12 ± 11 mmHg, respectively; mean ± SD) and reduction of LVdP/dtmax (650 ± 287 and 120 ± 103 mmHg·s−1) than landiolol (68 ± 20 and 64 ± 20 mmHg, and 897 ± 236 and 852 ± 240 mmHg·s−1, respectively). At the same concentrations, esmolol caused more profound reduction in MVO2 (40 ± 11 and 35 ± 10 μl·min−1 · g−1) than landiolol (50 ± 8 and 48 ± 8 μl·min−1 · g−1), respectively.

Conclusion

Our results indicate that in the isolated rabbit heart, landiolol and esmolol had equipotent negative chronotropic effects, however, landiolol had a less potent negative inotropic effect than esmolol.

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Affiliations

  1. Department of Anesthesiology, Yao Tokusyukai General Hospital, 3-15-38 Kyuhoji, Yao, Osaka, 581-0072, Japan

    Kazutoshi Ikeshita, Sumiko Toriyama, Tomoyuki Yamashita & Yoshiyuki Tani

  2. Department of Anesthesiology, Osaka City University Graduate School of Medicine, Osaka, Japan

    Kiyonobu Nishikawa, Tokuhiro Yamada & Akira Asada

Authors
  1. Kazutoshi Ikeshita
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  2. Kiyonobu Nishikawa
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  3. Sumiko Toriyama
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  4. Tomoyuki Yamashita
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  5. Yoshiyuki Tani
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  6. Tokuhiro Yamada
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Ikeshita, K., Nishikawa, K., Toriyama, S. et al. Landiolol has a less potent negative inotropic effect than esmolol in isolated rabbit hearts. J Anesth 22, 361–366 (2008). https://doi.org/10.1007/s00540-008-0640-4

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  • DOI: https://doi.org/10.1007/s00540-008-0640-4

Key words

  • Landiolol
  • Esmolol
  • Negative inotropic effect