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Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats

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Abstract

Purpose

Although the delta-opioid agonist SNC80 has been shown to attenuate hind-limb motor function and gray matter injury in normothermic rats subjected to spinal cord ischemia (SCI), its effects on white matter injury remain undetermined. In the present study, we investigated whether SNC80 could attenuate white matter injury in normothermic and mildly hypothermic rats.

Methods

Forty rats were randomly allocated to one of following five groups: vehicle or SNC80 with 10 min of SCI at 38°C (V-38-10m or SNC-38-10m, respectively), vehicle or SNC80 with 22 min of SCI at 35°C (V-35-22m or SNC-35-22m, respectively), or sham. SNC80 or vehicle was intrathecally administered 15 min before SCI. Forty-eight hours after reperfusion, the white matter injury was evaluated by the extent of vacuolation.

Results

The percent area of vacuolation in the ventral white matter was significantly lower in the SNC-38-10m and SNC-35-22m groups compared with that in the V-38-10m and V-35-22m groups, respectively (P < 0.05).

Conclusion

The results indicate that intrathecal treatment with the delta-opioid agonist SNC80 can attenuate the ventral white matter injury following SCI in rats under normothermic and mildly hypothermic conditions.

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Authors and Affiliations

  1. Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan

    Toshinori Horiuchi, Masahiko Kawaguchi, Naoko Kurita, Satoki Inoue, Takanori Sakamoto & Hitoshi Furuya

  2. Department of Pathology, Nara Medical University, Nara, Japan

    Mitsutoshi Nakamura & Noboru Konishi

Authors
  1. Toshinori Horiuchi
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  2. Masahiko Kawaguchi
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  3. Naoko Kurita
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  4. Satoki Inoue
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  5. Takanori Sakamoto
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  6. Mitsutoshi Nakamura
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  7. Noboru Konishi
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  8. Hitoshi Furuya
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Horiuchi, T., Kawaguchi, M., Kurita, N. et al. Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats. J Anesth 22, 32–37 (2008). https://doi.org/10.1007/s00540-007-0576-0

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  • DOI: https://doi.org/10.1007/s00540-007-0576-0

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