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Landiolol attenuates the cardiovascular response to tracheal intubation

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Abstract

Purpose

The objective of this prospective study was to compare the cardiovascular responses with or without landiolol to the induction of general anesthesia and tracheal intubation.

Methods

Twenty-two patients were randomly allocated to receive a loading dose of landiolol 125 µg kg−1 min−1 for 1 min followed by an infusion at 40 µg kg−1 min−1 for 4 min, or placebo. Four minutes after landiolol or placebo was started, propofol and succinylcholine were administered. Laryngoscopy and tracheal intubation were performed 1 min after the administration of succinylcholine. Heart rate and blood pressure were measured noninvasively every minute.

Results

A significant attenuation of the heart rate and blood pressure response were seen in the landiolol group for 3 min after intubation. Heart rate and systolic blood pressure in the landiolol group were decreased for 2 min before intubation and just before intubation compared with baseline, srespectively.

Conclusion

Continuous administration of landiolol before tracheal intubation results in the attenuation of cardiovascular response for tracheal intubation.

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References

  1. E Figueredo EM Garcia-Fuentes (2001) ArticleTitleAssessment of the efficacy of esmolol on the haemodynamic changes induced by laryngoscopy and tracheal intubation: a meta-analysis Acta Anaesthesiol Scand 45 1011–1022 Occurrence Handle10.1034/j.1399-6576.2001.450815.x Occurrence Handle11576054

    Article  PubMed  Google Scholar 

  2. VS Murthy TF Hwang BW Sandage AR Laddu (1986) ArticleTitleEsmolol and the adrenergic response to perioperative stimuli J Clin Pharmacol 26 A27–A35 Occurrence Handle2870083

    PubMed  Google Scholar 

  3. L Yuan YY Chia KT Jan CS Chen CH Wang LH Haung L Kang (1994) ArticleTitleThe effect of single bolus dose of esmolol for controlling the tachycardia and hypertension during laryngoscopy and tracheal intubation Acta Anaesthesiol Sin 32 147–152 Occurrence Handle7921858

    PubMed  Google Scholar 

  4. PL Liu S Gatt LD Gugino SR Mallampati BG Covino (1986) ArticleTitleEsmolol for control of increases in heart rate and blood pressure during tracheal intubation after thiopentone and succinylcholine Can Anaesth Soc J 33 556–562 Occurrence Handle3768764

    PubMed  Google Scholar 

  5. TJ Ebert JS Bernstein DF Stowe D Roerig JP Kampine (1990) ArticleTitleAttenuation of hemodynamic responses to rapid sequence induction and intubation in healthy patients with a single bolus of esmolol J Clin Anesth 2 243–252 Occurrence Handle10.1016/0952-8180(90)90104-B Occurrence Handle1975189

    Article  PubMed  Google Scholar 

  6. S Sheppard CJ Eagle L Strunin (1990) ArticleTitleA bolus dose of esmolol attenuates tachycardia and hypertension after tracheal intubation Can J Anaesth 37 202–205 Occurrence Handle1968783

    PubMed  Google Scholar 

  7. D Oxorn JW Knox J Hill (1990) ArticleTitleBolus doses of esmolol for the prevention of perioperative hypertension and tachycardia Can J Anaesth 37 206–209 Occurrence Handle1968784

    PubMed  Google Scholar 

  8. S Sharma S Mitra VK Grover R Kalra (1996) ArticleTitleEsmolol blunts the haemodynamic responses to tracheal intubation in treated hypertensive patients Can J Anaesth 43 778–782 Occurrence Handle8840055

    PubMed  Google Scholar 

  9. EK Zsigmond E Barabas GM Korenaga (1988) ArticleTitleEsmolol attenuates tachycardia caused by tracheal intubation: a double-blind study Int J Clin Pharmacol Ther Toxicol 26 225–231 Occurrence Handle2900819

    PubMed  Google Scholar 

  10. SC Wang CC Wu MS Lin CF Chang (1994) ArticleTitleUse of esmolol to prevent hemodynamic changes during intubation in general anesthesia Acta Anaesthesiol Sin 32 141–146 Occurrence Handle7921857

    PubMed  Google Scholar 

  11. JB Leslie RW Kalayjian TM McLoughlin JR Plachetka (1989) ArticleTitleAttenuation of the hemodynamic responses to endotracheal intubation with preinduction intravenous labetalol J Clin Anesth 1 194–200 Occurrence Handle10.1016/0952-8180(89)90041-X Occurrence Handle2627387

    Article  PubMed  Google Scholar 

  12. JS Bernstein TJ Ebert DF Stowe WT Schmeling MA Nelson MP Woods (1989) ArticleTitlePartial attenuation of hemodynamic responses to rapid sequence induction and intubation with labetalol J Clin Anesth 1 444–451 Occurrence Handle10.1016/0952-8180(89)90009-3 Occurrence Handle2696507

    Article  PubMed  Google Scholar 

  13. A Kitamura A Sakamoto T Inoue R Ogawa (1997) ArticleTitleEfficacy of an ultrashort-acting beta-adrenoceptor blocker (ONO-1101) in attenuating cardiovascular responses to endotracheal intubation Eur J Clin Pharmacol 51 467–471 Occurrence Handle10.1007/s002280050232 Occurrence Handle9112061

    Article  PubMed  Google Scholar 

  14. H Atarashi A Kuruma M Yashima H Saitoh T Ino Y Endoh H Hayakawa (2000) ArticleTitlePharmacokinetics of landiolol hydrochloride, a new ultra-short-acting S61538-blocker, in patients with cardiac arrhythmias Clin Pharmacol Ther 68 143–150 Occurrence Handle10.1067/mcp.2000.108733 Occurrence Handle10976545

    Article  PubMed  Google Scholar 

  15. A Sugiyama A Takahara K Hashimoto (1999) ArticleTitleElectrophysiologic, cardiohemodynamic and beta-blocking actions of a new ultra-short-acting beta-blocker, ONO-1101, assessed by the in vivo canine model in comparison with esmolol J Cardiovasc Pharmacol 34 70–77 Occurrence Handle10.1097/00005344-199907000-00012 Occurrence Handle10413070

    Article  PubMed  Google Scholar 

  16. S Motomura A Hagihara Y Narumi K Hashimoto (1998) ArticleTitleTime course of a new ultrashort-acting beta-adrenoceptor-blocking drug, ONO-1101: comparison with those of esmolol and propranolol by using the canine isolated, blood-perfused heart preparations J Cardiovasc Pharmacol 31 431–440 Occurrence Handle10.1097/00005344-199803000-00015 Occurrence Handle9514189

    Article  PubMed  Google Scholar 

  17. J Sasao SD Tarver JD Kindscher C Taneyama KT Benson H Goto (2001) ArticleTitleIn rabbits, landiolol, a new ultra-short-acting beta-blocker, exerts a more potent negative chronotropic effect and less effect on blood pressure than esmolol Can J Anaesth 48 985–989 Occurrence Handle11698317

    PubMed  Google Scholar 

  18. RK Stoelting (1977) ArticleTitleCirculatory changes during direct laryngoscopy and tracheal intubation: influence of duration of laryngoscopy with or without prior lidocaine Anesthesiology 47 381–384 Occurrence Handle900548

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesiology, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan

    Toru Goyagi, Makoto Tanaka & Toshiaki Nishikawa

Authors
  1. Toru Goyagi
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  2. Makoto Tanaka
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  3. Toshiaki Nishikawa
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Goyagi, T., Tanaka, M. & Nishikawa, T. Landiolol attenuates the cardiovascular response to tracheal intubation. J Anesth 19, 282–286 (2005). https://doi.org/10.1007/s00540-005-0347-8

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  • DOI: https://doi.org/10.1007/s00540-005-0347-8

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