Abstract:
We report a case of pseudomembranous colitis that developed in a patient with liver cirrhosis during anti-tuberculosis therapy with rifampicin and isoniazid. The association between rifampicin and pseudomembranous colitis has been controversial; this report, however, supports the association. Colonoscopy performed 3 days after the onset of the pseudomembranous colitis revealed only reddish patches and a few aphthoid lesions, but 4 days later pseudomembranes were apparent. The pseudomembranous colitis was successfully controlled by discontinuation of the anti-tuberculosis agents, along with the administration of lactic acid bacteria, without vancomycin or metronidazole. Possible predisposing factors for the development of pseudomembranous colitis in this patient are also discussed.
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Received: February 8, 1999 / Accepted: August 27, 1999
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Nakajima, A., Yajima, S., Shirakura, T. et al. Rifampicin-associated pseudomembranous colitis. J Gastroenterol 35, 299–303 (2000). https://doi.org/10.1007/s005350050350
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DOI: https://doi.org/10.1007/s005350050350