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Journal of Gastroenterology

, Volume 34, Issue 2, pp 269–274 | Cite as

Disappearance of serum HCV-RNA after short-term prednisolone therapy in a patient with chronic hepatitis C associated with autoimmune hepatitis-like serological manifestations

  • Masahide Yoshikawa
  • Masahisa Toyohara
  • Yoshiko Yamane
  • Mayumi Mimura
  • Yoji Miyamoto
  • Shigehiko Ueda
  • Hiroshi Kawamoto
  • Hiroshi Fukui
  • Tatsuro Kobayashi
  • Eijiro Hayashi
  • Akira Nakamura

Abstract:

We report a 70-year-old woman with chronic hepatitis C associated with autoimmune hepatitis (AIH)-like serological manifestations, in whom elimination of hepatitis C virus (HCV) was observed after corticosteroid treatment. The patient was infected with HCV, genotype Ib, but had several laboratory findings, such as markedly elevated serum γ-globulin and IgG, characteristic of AIH, as well as a high titer of an anti-nuclear antibody. An ultrasound (US)-guided liver biopsy disclosed chronic active hepatitis F3. Corticosteroid worsened her liver function test results and raised amounts of HCV-RNA in the serum. Withdrawal of the corticosteroid led to prompt normalization of transaminase levels and the disappearance of serum HCV-RNA, determined by reverse transcription-polymerase chain reaction (RT-PCR). For 4 years, up to the time of this study, her transaminase values have been normal and HCV viremia was not detected by repeated RT-PCR. We believe this to be the first reported case in which eradication of HCV was achieved by corticosteroid therapy alone, without the introduction of interferon.

Key words: HCV infection corticosteroid autoimmune hepatitis chronic hepatitis C 

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Copyright information

© Springer-Verlag Tokyo 1999

Authors and Affiliations

  • Masahide Yoshikawa
    • 1
  • Masahisa Toyohara
    • 1
  • Yoshiko Yamane
    • 1
  • Mayumi Mimura
    • 1
  • Yoji Miyamoto
    • 1
  • Shigehiko Ueda
    • 1
  • Hiroshi Kawamoto
    • 1
  • Hiroshi Fukui
    • 1
  • Tatsuro Kobayashi
    • 2
  • Eijiro Hayashi
    • 2
  • Akira Nakamura
    • 3
  1. 1.Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 634-8522, JapanJP
  2. 2.Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Osaka, JapanJP
  3. 3.Department of Internal Medicine, Sanda Municipal Hospital, Sanda, JapanJP

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