Abstract:
A 66-year-old Japanese man had a positive fecal occult blood test at a regular check-up, and a large polypoid mass was detected in the cecum by barium enema study. Colonoscopy showed a submucosal tumor with ulcer protruding into the cecal lumen. A large-forceps biopsy specimen was taken from the bottom of the ulcer. With the tentative diagnosis of neurogenic tumor, ileocecal resection was performed. The tumor showed spindle-cell proliferation in a concentric or fascicular pattern. Immunohistochemically, the tumor cells were diffusely positive for S-100 protein, and they had intracytoplasmic periodic acid Schiff (PAS)-positive crystalloids. The mitosis count was low (about 1 per 20 high-power fields). The pathological diagnosis of this tumor was benign gastrointestinal schwannoma. A large number of schwannoma cases have been reported since 1910 when Verocay reported it as a true tumor that stemmed from Schwann cells and did not contain neuroganglion cells. However, gastrointestinal schwannomas are rare, and schwannomas of the large intestine are extremely rare. We reviewed 40 cases already reported in Japan and this present case in order to clarify the clinicopathological features of this tumor.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
(Received Jan. 6, 1998; accepted June 26, 1998)
Rights and permissions
About this article
Cite this article
Tomozawa, S., Masaki, T., Matsuda, K. et al. A schwannoma of the cecum: Case report and review of Japanese schwannomas in the large intestine. J Gastroenterol 33, 872–875 (1998). https://doi.org/10.1007/s005350050191
Issue Date:
DOI: https://doi.org/10.1007/s005350050191