Abstract:
Endoscopy is not significantly better than fiberscopy for the diagnosis of minute cancers of the digestive tract. However, labeling of these lesions with an agent that can be detected videoendoscopically, with subsequent computer processing of the electronic signals, should facilitate endoscopic diagnosis of microlesions. We developed an antibody labeled with an indocyanine green(ICG) derivative that has a specific fluorescence emission at 807 nm upon excitation at 768 nm. The physiochemical characteristics of this labeled antibody resemble those of ICG. The activity of the antibody is suitable for immunohistochemical staining, and the antibody fluoresces under infrared ray excitation. This antibody should prove useful for performing vital immunostaining for infrared endoscopy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
(Received June 20, 1997; accepted Nov. 28, 1997)
Rights and permissions
About this article
Cite this article
Muguruma, N., Ito, S., Hayashi, S. et al. Antibodies labeled with fluorescence-agent excitable by infrared rays. J Gastroenterol 33, 467–471 (1998). https://doi.org/10.1007/s005350050116
Issue Date:
DOI: https://doi.org/10.1007/s005350050116