Abstract:
A submucosal tumor was resected endoscopically from the duodenal bulb in a 43-year-old man complaining of epigastric discomfort. The tumor, measuring 22 × 20 × 19 mm, consisted mainly of Brunner's glands with no atypia. However, close histologic examination disclosed a focus of glands with cellular and structural atypia. The atypical glands showed staining by periodic acid-Schiff, alcian blue, and high iron-diamine methods. Mucin histochemistry was examined, and the atypical glands resembled the excretory ducts rather than the acinar cells of the tumor. Immunohistochemically, positivity for MIB-1 was high (38.0%), and p53-positive cells were detected sporadically in the atypical glands. These results indicated that the atypical glands probably represented a neoplastic lesion. Brunner's gland adenomas associated with foci of true neoplasm are very rare; only two cases, including one patient with microcarcinoid tumors, have been reported.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: December 3, 1998 / Accepted: June 25, 1999
Rights and permissions
About this article
Cite this article
Fujimaki, E., Nakamura, Si., Sugai, T. et al. Brunner's gland adenoma with a focus of p53-positive atypical glands. J Gastroenterol 35, 155–158 (2000). https://doi.org/10.1007/s005350050029
Issue Date:
DOI: https://doi.org/10.1007/s005350050029