Microbiome research is a rapidly advancing field in human cancers. Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. Recent studies have found that F. nucleatum can promote gastrointestinal tumor progression and affect the prognosis of the disease. In addition, F. nucleatum may contribute to the chemo-resistance of gastrointestinal cancers. This review summarizes recent progress in the pathogenesis of F. nucleatum and its impact on gastrointestinal cancer.
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This work was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Grant numbers 17H04273, 17K19702 and 17KK0195 (to Y.B.).
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Liu, Y., Baba, Y., Ishimoto, T. et al. Progress in characterizing the linkage between Fusobacterium nucleatum and gastrointestinal cancer. J Gastroenterol 54, 33–41 (2019). https://doi.org/10.1007/s00535-018-1512-9