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A large volume of visceral adipose tissue leads to severe acute pancreatitis

  • Original Article—Liver, Pancreas, and Biliary Tract
  • Published:
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Abstract

Background

Obesity plays an important role in acute pancreatitis. Assuming that the volume of visceral adipose tissue (VAT) directly influences the severity of acute pancreatitis, we investigated the relationship between VAT and acute pancreatitis.

Methods

Data were collected consecutively from 124 patients who were diagnosed with acute pancreatitis. Body mass index (BMI) was calculated from the database. Computed tomography was performed in all patients, and VAT, subcutaneous adipose tissue (SAT), and waist circumference (WC) were measured at the level of the intervertebral disk between L2 and L3. Atlanta criteria were adopted to define severe acute pancreatitis. Clinical courses were investigated, and the Ranson and acute physiology and chronic health evaluation II (APACHE II) scores were calculated for all patients.

Results

Forty-eight patients had severe acute pancreatitis (38.7%), and 76 were mild cases. BMI, VAT, SAT, and WC were correlated with the severity of acute pancreatitis in a univariate analysis, but only VAT had a strong correlation with severe acute pancreatitis in the multivariate analysis. In a trend analysis, not only severity but also the presence of pseudocysts (local complication) and prognostic factors (Ranson and APACHE II scores) were significantly related to VAT volume. In particular, the presence of a pancreatic pseudocyst was strongly related to VAT volume (p < 0.001).

Conclusion

In acute pancreatitis, peripancreatic VAT has a stronger correlation with severe acute pancreatitis than BMI or WC. VAT volume is strongly correlated with the formation of a pseudocyst and with systemic inflammatory response syndrome in patients with acute pancreatitis and high VAT volume may lead to severe acute pancreatitis.

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Abbreviations

AP:

Acute pancreatitis

CT:

Computed tomography

BMI:

Body mass index

APACHE:

Acute physiology and chronic health evaluation

SIRS:

Systemic inflammatory response syndrome

VAT:

Visceral adipose tissue

SAT:

Subcutaneous adipose tissue

WC:

Waist circumference

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Authors and Affiliations

  1. Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Yoko Yashima, Hiroyuki Isayama, Takeshi Tsujino, Rie Nagano, Keisuke Yamamoto, Suguru Mizuno, Hiroshi Yagioka, Kazumichi Kawakubo, Takashi Sasaki, Hirofumi Kogure, Yousuke Nakai, Kenji Hirano, Naoki Sasahira, Minoru Tada, Takao Kawabe, Kazuhiko Koike & Masao Omata

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  1. Yoko Yashima
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  2. Hiroyuki Isayama
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  3. Takeshi Tsujino
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  4. Rie Nagano
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  5. Keisuke Yamamoto
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  6. Suguru Mizuno
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  7. Hiroshi Yagioka
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  13. Naoki Sasahira
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  14. Minoru Tada
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  15. Takao Kawabe
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  16. Kazuhiko Koike
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  17. Masao Omata
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Corresponding author

Correspondence to Hiroyuki Isayama.

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Yashima, Y., Isayama, H., Tsujino, T. et al. A large volume of visceral adipose tissue leads to severe acute pancreatitis. J Gastroenterol 46, 1213–1218 (2011). https://doi.org/10.1007/s00535-011-0430-x

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  • DOI: https://doi.org/10.1007/s00535-011-0430-x

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