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The demographic characteristics and health-related quality of life in a large cohort of reflux esophagitis patients in Japan with reference to the effect of lansoprazole: the REQUEST study

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Abstract

Background

Patients with reflux esophagitis (RE) in Western countries have impaired health-related quality of life (HRQOL). However, few data are available concerning HRQOL in Asian patients with RE.

Aim

To determine the demographic characteristics, HRQOL, and the impact of lansoprazole treatment in a large cohort of RE patients in Japan.

Methods

Patients with RE were enrolled. Lansoprazole was administered for 8 weeks and HRQOL assessed using the SF-8 and a newly developed questionnaire for RE-specific HRQOL (RESQ) at baseline and after 4 and 8 weeks of treatment.

Results

Among enrolled patients, 2320 patients with the Los Angeles classification grade A to D esophagitis at enrollment to the study were analyzed. A higher proportion of older women was observed (in the group of patients aged ≥60 years, 61.3% were women). Prevalence of obesity was 4.7%. At baseline, HRQOL scores of RE patients were well below the mean for the Japanese general population in all domains of the SF-8. After 8 weeks of treatment with lansoprazole, these scores significantly improved to the levels of the general population (P < 0.01). Scores of RESQ also significantly improved (P < 0.01).

Conclusions

Demographically, RE patients in Japan differ from those in Western countries with an increased proportion in older women and lower prevalence of obesity. RE has a marked negative impact on HRQOL, which is significantly improved by treatment with lansoprazole.

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Authors and Affiliations

  1. Department of Comprehensive Medicine, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba, Sendai, 980-8574, Japan

    Michio Hongo

  2. Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan

    Yoshikazu Kinoshita

  3. Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    Hiroto Miwa

  4. Department of Gastroenterology and Hepatology, Saiseikai Nakatsu Hospital, Osaka, Japan

    Kiyoshi Ashida

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  1. Michio Hongo
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  2. Yoshikazu Kinoshita
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  3. Hiroto Miwa
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  4. Kiyoshi Ashida
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Hongo, M., Kinoshita, Y., Miwa, H. et al. The demographic characteristics and health-related quality of life in a large cohort of reflux esophagitis patients in Japan with reference to the effect of lansoprazole: the REQUEST study. J Gastroenterol 43, 920–927 (2008). https://doi.org/10.1007/s00535-008-2257-7

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  • DOI: https://doi.org/10.1007/s00535-008-2257-7

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