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Leukocytapheresis for the treatment of active pouchitis: a pilot study

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Abstract

Background

Pouchitis is a major long-term complication of ileal pouch-anal anastomosis for ulcerative colitis. The aim of this study is to investigate the efficacy of leukocytapheresis for the treatment of active pouchitis.

Methods

Eight patients with active pouchitis received leukocytapheresis weekly for 5 weeks in an open-label treatment protocol together with baseline therapy.

Results

Patients showed significant improvement in their pouchitis disease activity index scores, from 9.5 (range, 8–10) to 4.0 (range, 2–8) (P < 0.05). Six (75%) of the 8 treated patients achieved remission. No adverse events were observed.

Conclusions

Leukocytapheresis therapy could be a new therapeutic strategy for patients with pouchitis after ileal pouch-anal anastomosis for ulcerative colitis. These encouraging results lead us to propose a randomized controlled trial.

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Authors and Affiliations

  1. Kurume Coloproctology Center, Kurume, Japan

    Yasumi Araki, Takaaki Nagae, Yuji Tou, Motonori Nakagawa, Yasue Iwatani, Masakazu Harada, Hiroyuki Ozasa & Toshihiro Noake

  2. Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan

    Keiichi Mitsuyama & Michio Sata

Authors
  1. Yasumi Araki
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  2. Keiichi Mitsuyama
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  3. Takaaki Nagae
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  4. Yuji Tou
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  5. Motonori Nakagawa
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  6. Yasue Iwatani
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  7. Masakazu Harada
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  8. Hiroyuki Ozasa
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  9. Michio Sata
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  10. Toshihiro Noake
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Araki, Y., Mitsuyama, K., Nagae, T. et al. Leukocytapheresis for the treatment of active pouchitis: a pilot study. J Gastroenterol 43, 571–575 (2008). https://doi.org/10.1007/s00535-008-2199-0

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  • DOI: https://doi.org/10.1007/s00535-008-2199-0

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