Skip to main content

Advertisement

SpringerLink
Log in

Clinical impact of a newly developed capsule endoscope: usefulness of a real-time image viewer for gastric transit abnormality

  • Alimmentary Tract
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Background

A new capsule endoscope has been developed by Olympus Medical Systems. The visualization and usefulness of its real-time image viewer for gastric transit abnormality were evaluated by using this new device.

Methods

Thirty-seven consecutive patients were enrolled. In cases of gastric transit abnormality (gastric transit > 60 min, detected by the real-time viewer), intramuscular metoclopramide (10 mg) was administered. Diagnostic yield and gastric and small bowel transit times in ten patients receiving (group A) and 27 not receiving (group B) metoclopramide were analyzed.

Results

Median gastric transit time was longer in group A than in group B (110 vs. 24 min; P < 0.0001). Conversely, median small bowel transit time was shorter in group A than in group B (270 vs. 347 min; P < 0.05). Further, small bowel transit was complete in 9/10 patients (90%) in group A, and in 23/27 patients (85%) in group B, but the difference was not significant. Overall diagnostic yield was 78% (29/37 patients), and there was no significant difference in the ratio of abnormal findings documented between group A (8/10, 80%) and group B (21/27, 78%) patients.

Conclusions

This new technology allowed clear image interpretation, and the real-time viewer was useful for detecting gastric transit abnormalities and determining a need for metoclopramide administration in patients undergoing capsule endoscopy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Iddan G, Meron G, Glukhovsky A, Swain P. Wireless capsule endoscopy. Nature 2000;405:417.

    Article  PubMed  CAS  Google Scholar 

  2. Meron GD. The development of the swallowable video capsule (M2A). Gastrointest Endosc 2000;52:817–818.

    Article  PubMed  CAS  Google Scholar 

  3. Appleyard M, Glukhovsky A, Swain P. Wireless-capsule diagnostic endoscopy for recurrent small-bowel bleeding. N Engl J Med 2001;344:232–233.

    Article  PubMed  CAS  Google Scholar 

  4. Lewis BS, Swain P. Capsule endoscopy in the evaluation of patients with suspected small intestinal bleeding: results of a pilot study. Gastrointest Endosc 2002;56:349–353.

    Article  PubMed  Google Scholar 

  5. Eliakim R, Fischer D, Suissa A, Yassin K, Katz D, Guttman N, et al. Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease. Eur J Gastroenterol Hepatol 2003;15:363–367.

    Article  PubMed  Google Scholar 

  6. Chong AKK, Taylor ACF, Miller AM, Desmond PV. Initial experience with capsule endoscopy at a major referral hospital. Med J Aust 2003;178:537–540.

    PubMed  Google Scholar 

  7. Mylonaki M, Fritscher-Ravens A, Swain P. Wireless capsule endoscopy: a comparison with push enteroscopy in patients with gastroscopy and colonoscopy negative gastrointestinal bleeding. Gut 2003;52:1122–1126.

    Article  PubMed  CAS  Google Scholar 

  8. Pennazio M, Santucci R, Rondonotti E, Abbiati C, Beccari G, Rossini FP, et al. Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: report of 100 consecutive cases. Gastroenterology 2004;126:643–653.

    Article  PubMed  Google Scholar 

  9. Selby W. Complete small-bowel transit in patients undergoing capsule endoscopy: determining factors and improvement with metoclopramide. Gastrointest Endosc 2005;61:80–85.

    Article  PubMed  Google Scholar 

  10. Dai N, Gubler C, Hengstler P, Meyenberger C, Bauerfeind P. Improved capsule endoscopy after bowel preparation. Gastrointest Endosc 2005;61:28–31.

    Article  PubMed  Google Scholar 

  11. Niv Y, Niv G, Wiser K, Demarco DC. Capsule endoscopy—comparison of two strategies of bowel preparation. Aliment Pharmacol Ther 2005;22:957–962.

    Article  PubMed  CAS  Google Scholar 

  12. Fireman Z, Paz D, Kopelman Y. Capsule endoscopy: improving transit time and image view. World J Gastroenterol 2005;11:5863–5866.

    PubMed  Google Scholar 

  13. Gat D, Fireman Z, Scapa E, Lewkowicz S, Glukhovsky A, Shreiber RE, et al. Transit times for the capsule endoscope—effect of colon prep on small bowel transit time of the capsule (abstract). Endoscopy 2001;33:S1–2004.

    Article  Google Scholar 

  14. Ben-Soussan E, Savoye G, Antonietti M, Ramirez S, Ducrotte P, Lerebours E. Is a 2-liter PEG preparation useful before capsule endoscopy? J Clin Gastroenterol 2005;39:381–384.

    Article  PubMed  Google Scholar 

  15. Rabine JC, Barnett JL. Management of the patient with gastroparesis. J Clin Gastroenterol 2001;32:11–18.

    Article  PubMed  CAS  Google Scholar 

  16. Ganzini L, Casey DE, Hoffman WF, McCall AL. The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders. Arch Intern Med 1993;153:1469–1475.

    Article  PubMed  CAS  Google Scholar 

  17. Annese V, Janssens J, Vantrappen G, Tack J, Peeters JL, Willemse P, et al. Erythromycin accelerates gastric emptying by inducing antral contractions and improved gastroduodenal coordination. Gastroenterology 1992;102:823–828.

    PubMed  CAS  Google Scholar 

  18. Degen L, Matzinger D, Merz M, Appel-Dingemanse S, Osborne S, Luchinger S, et al. Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects. Aliment Pharmacol Ther 2001;15:1745–1751.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan

    Haruhiko Ogata, Koichiro Kumai, Hiroyuki Imaeda & Koichi Aiura

  2. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Tadakazu Hisamatsu, Susumu Okamoto, Yasushi Iwao & Toshifumi Hibi

  3. Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan

    Yoshinori Sugino

  4. Department of Surgery, Keio University School of Medicine, Tokyo, Japan

    Masaki Kitajima

Authors
  1. Haruhiko Ogata
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Koichiro Kumai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroyuki Imaeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Koichi Aiura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tadakazu Hisamatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Susumu Okamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yasushi Iwao
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yoshinori Sugino
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Masaki Kitajima
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Toshifumi Hibi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ogata, H., Kumai, K., Imaeda, H. et al. Clinical impact of a newly developed capsule endoscope: usefulness of a real-time image viewer for gastric transit abnormality. J Gastroenterol 43, 186–192 (2008). https://doi.org/10.1007/s00535-007-2140-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00535-007-2140-y

Key words

Search

Navigation