Skip to main content

Advertisement

SpringerLink
Log in

Autoimmune pancreatitis: a message from Japan

  • Overview
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Autoimmune pancreatitis (AIP) is a unique form of chronic pancreatitis generally observed in aged people and characterized by the presence of autoantibodies,1–3 elevated levels of immunoglobulins,4 enlargement of the pancreas (diffuse or focal) on ultrasonography (US) or computed tomography (CT),1–3,5 diffuse narrowing of the main pancreatic duct (MPD) with an irregular wall,1,3,5–8 and pathologic features of dense lymphoplasmacytic inflammation and fibrosis, as well as a favorable response to steroid therapy.1–3,5,8 The clinical findings in AIP include obstructive jaundice secondary to biliary stenosis, mild epigastralgia, and diabetes mellitus. The clinical, laboratory, and radiological features respond promptly to oral steroid therapy.1–3,5,6,8 Although prompt response to oral steroid therapy may be helpful in the differential diagnosis of AIP, careful imaging studies are necessary to exclude cancer of the pancreas or common bile duct (CBD).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. T Ito I Nakano S Koyanagi T Miyahara Y Migita K Ogoshi et al. (1997) ArticleTitleAutoimmune pancreatitis as a new clinical entity: Three cases of autoimmune pancreatitis with effective steroid therapy Dig Dis Sci 42 1458–68 Occurrence Handle9246047 Occurrence Handle10.1023/A:1018862626221 Occurrence Handle1:STN:280:ByiA1cfotFA%3D

    Article  PubMed  CAS  Google Scholar 

  2. K Okazaki K Uchida M Ohana H Nakase S Uose M Inai et al. (2000) ArticleTitleAutoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response Gastroenterology 118 573–81 Occurrence Handle10702209 Occurrence Handle10.1016/S0016-5085(00)70264-2 Occurrence Handle1:CAS:528:DC%2BD3cXit1Smsb0%3D

    Article  PubMed  CAS  Google Scholar 

  3. K Yoshida F Toki T Takeuchi S Watanabe K Shiratori N Hayashi (1995) ArticleTitleChronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis Dig Dis Sci 40 1561–8 Occurrence Handle7628283 Occurrence Handle10.1007/BF02285209 Occurrence Handle1:STN:280:ByqA2MvkvFA%3D

    Article  PubMed  CAS  Google Scholar 

  4. H Hamano S Kawa A Horiuchi H Unno N Furuya T Akamatsu et al. (2001) ArticleTitleHigh serum Ig4 concentrations in patients with sclerosing pancreatitis N Engl J Med 344 732–8 Occurrence Handle11236777 Occurrence Handle10.1056/NEJM200103083441005 Occurrence Handle1:CAS:528:DC%2BD3MXitFamt7k%3D

    Article  PubMed  CAS  Google Scholar 

  5. N Furukawa T Muranaka K Yasumori R Matsubayashi K Hayashida Y Arita (1998) ArticleTitleAutoimmune pancreatitis: radiologic findings in three histologically proven cases J Comput Assist Tomogr 22 880–3 Occurrence Handle9843225 Occurrence Handle10.1097/00004728-199811000-00007 Occurrence Handle1:STN:280:DyaK1M%2Flslemuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  6. S Nakano I Takeda K Kitamura H Watahiki Y Iimura M Takenaka (1978) ArticleTitleVanishing tumor of the abdomen in patient with Sjögren's syndrome Dig Dis Sci 23 75s–9s Occurrence Handle10.1007/BF01072494

    Article  Google Scholar 

  7. F Toki T Kozu I Oi T Nakasako M Suzuki F Hanyu (1992) ArticleTitleAn unusual type of chronic pancreatitis showing diffuse irregular narrowing of the entire main pancreatic duct on ERP—a report of four cases (abstract) Endoscopy 24 640

    Google Scholar 

  8. A Horiuchi S Kawa T Akamatsu Y Aoki K Mukawa N Furuya et al. (1998) ArticleTitleCharacteristic pancreatic duct appearance in autoimmune chronic pancreatitis: a case report and review of the Japanese literature Am J Gastroenterol 93 260–3 Occurrence Handle9468255 Occurrence Handle10.1111/j.1572-0241.1998.00260.x Occurrence Handle1:STN:280:DyaK1c7islOksQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  9. H Sarles I Sarles R Muratore C Guien (1961) ArticleTitleChronic inflammatory sclerosis of the pancreas—an autonomous pancreatic disease? Am J Dig Dis 6 688–98 Occurrence Handle13746542 Occurrence Handle10.1007/BF02232341 Occurrence Handle1:STN:280:CC%2BD28nisFc%3D

    Article  PubMed  CAS  Google Scholar 

  10. R Waldram H Kopelman D Tsantoulas R Williams (1975) ArticleTitleChronic pancreatitis, sclerosing cholangitis, and sicca complex in two siblings Lancet 1 550–2 Occurrence Handle47019 Occurrence Handle10.1016/S0140-6736(75)91560-3 Occurrence Handle1:STN:280:CSqC3Mjps1c%3D

    Article  PubMed  CAS  Google Scholar 

  11. EP DiMagno (2003) ArticleTitleAutoimmune chronic pancreatitis: a plea for simplification and consistency Clin Gastroenterol Hepatol 1 421–2 Occurrence Handle15017639 Occurrence Handle10.1016/S1542-3565(03)00223-4

    Article  PubMed  Google Scholar 

  12. B Etemad DC Whitcomb (2001) ArticleTitleChronic pancreatitis: diagnosis, classification, and new genetic developments Gastroenterology 120 682–707 Occurrence Handle11179244 Occurrence Handle10.1053/gast.2001.22586 Occurrence Handle1:STN:280:DC%2BD3M7lvV2mtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  13. KP Kim MH Kim SS Lee DW Seo SK Lee (2004) ArticleTitleAutoimmune pancreatitis: it may be a worldwide entity Gastroenterology 126 1214 Occurrence Handle15057766 Occurrence Handle10.1053/j.gastro.2004.02.044

    Article  PubMed  Google Scholar 

  14. R Sutton (2005) ArticleTitleAutoimmune pancreatitis—also a Western disease Gut 54 581–3 Occurrence Handle15831898 Occurrence Handle10.1136/gut.2004.058438 Occurrence Handle1:STN:280:DC%2BD2M7pslynsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  15. H Sarles (1965) ArticleTitleProposal adopted unanimously by the participants of the Symposium, Marseilles 1963 Bibl Gastroenterol 7 7–8

    Google Scholar 

  16. MV Singer K Gyr H Sarles (1985) ArticleTitleRevised classification of pancreatitis: report of the Second international symposium on the classification of pancreatitis in Marseille, France, March 28–30, 1984 Gastroenterology 89 683–5 Occurrence Handle4018507 Occurrence Handle1:STN:280:BiqB2MfosFw%3D

    PubMed  CAS  Google Scholar 

  17. H Sarles G Adler R Dani C Frey L Gullo H Harada et al. (1989) ArticleTitleThe pancreatitis classification of Marseilles–Rome 1988 Scand J Gastroenterol 24 641–2 Occurrence Handle2814334 Occurrence Handle1:STN:280:By%2BD2cfoslA%3D

    PubMed  CAS  Google Scholar 

  18. T Homma H Harada M Koizumi (1997) ArticleTitleDiagnostic criteria for chronic pancreatitis by the Japan Pancreas Society Pancreas 15 14–5 Occurrence Handle9211487 Occurrence Handle10.1097/00006676-199707000-00002 Occurrence Handle1:STN:280:ByiA2MrivFY%3D

    Article  PubMed  CAS  Google Scholar 

  19. M Otsuki (2004) ArticleTitleChronic pancreatitis. The problems of diagnostic criteria Pancreatology 4 28–41 Occurrence Handle14988656 Occurrence Handle10.1159/000077066

    Article  PubMed  Google Scholar 

  20. Members of the Criteria Committee for Autoimmune Pancreatitis of the Japan Pancreas Society. Diagnostic criteria for autoimmune pancreatitis 2002 by the Japan Pancreas Society. Suizou 2002;17:585–7

    Google Scholar 

  21. RK Pearson DS Longnecker ST Chari TC Smyrk K Okazaki L Frulloni et al. (2003) ArticleTitleControversies in clinical pancreatology: autoimmune pancreatitis: does it exist? Pancreas 27 1–13 Occurrence Handle12826899 Occurrence Handle10.1097/00006676-200307000-00001

    Article  PubMed  Google Scholar 

  22. KP Kim MH Kim JC Kim SS Lee DW Seo SK Lee (2006) ArticleTitleDiagnostic criteria for autoimmune chronic pancreatitis revisited World J Gastroenterol 12 2487–96 Occurrence Handle16688792

    PubMed  Google Scholar 

  23. EK Choi MH Kim JC Kim J Han DW Seo SS Lee et al. (2006) ArticleTitleThe Japanese diagnostic criteria for autoimmune chronic pancreatitis: is it completely satisfactory? Pancreas 33 13–9 Occurrence Handle16804407 Occurrence Handle10.1097/01.mpa.0000222318.59360.68

    Article  PubMed  Google Scholar 

  24. ST Chari TC Smyrk MJ Levy MD Topazian N Takahashi L Zhang et al. (2006) ArticleTitleDiagnosis of autoimmune pancreatitis: the Mayo Clinic experience Clin Gastroenterol Hepatol 4 1010–6 Occurrence Handle16843735 Occurrence Handle10.1016/j.cgh.2006.05.017

    Article  PubMed  Google Scholar 

  25. K Okazaki S Kawa T Kamisawa T Naruse S Tanaka I Nishimori et al. (2006) ArticleTitleClinical Diagnostic Criteria of Autoimmune Pancreatitis—revised proposal J Gastroenterol 41 626–31 Occurrence Handle16932998 Occurrence Handle10.1007/s00535-006-1868-0

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, 1-1 Iseigaoka, Yahatanishi, Kitakyushu, 807-8555, Japan

    Makoto Otsuki

Authors
  1. Makoto Otsuki
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Otsuki, M. Autoimmune pancreatitis: a message from Japan. J Gastroenterol 42 (Suppl 18), 1–5 (2007). https://doi.org/10.1007/s00535-007-2058-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00535-007-2058-4

Key words

Search

Navigation