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Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility

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Abstract

Background

Impairment of gastric emptying is well recognized in patients with diabetes mellitus (DM), especially long-standing insulin-dependent diabetes mellitus (IDDM). The aim of this study was to evaluate the cause of delayed gastric emptying in DM patients.

Methods

In 16 controls, 16 non-insulin-dependent diabetes mellitus (NIDDM) patients and 23 IDDM patients, gastric emptying was studied using the 13C octanoic acid breath test. Breath samples were taken before a test meal labeled with 100 mg of 13C octanoic acid, and at 15-min intervals over a 300-min period postprandially.

Results

In all DM patients, the gastric emptying coefficient was lower than that in the controls (P < 0.05), and lag time and half-emptying time were significantly longer (P < 0.05). Both NIDDM and IDDM patients showed delayed 13CO2 excretion compared with the controls, but IDDM patients showed more delayed gastric emptying than NIDDM patients (P < 0.05). There were no significant differences in sex, HbA1c level, or the rate of neuropathy between the two groups.

Conclusions

IDDM patients showed delayed gastric emptying compared with NIDDM patients, and the 13C octanoic acid breath test is useful for evaluating DM patients with delayed gastric emptying.

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Authors and Affiliations

  1. Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Masahiro Matsumoto, Rie Yoshimura, Hirotada Akiho, Naomi Higuchi, Kunihisa Kobayashi, Noriaki Matsui, Kentaro Taki, Hiroyuki Murao, Haruei Ogino, Kenji Kanayama, Yorinobu Sumida, Takahiro Mizutani, Kuniomi Honda, Shigetaka Yoshinaga, Soichi Itaba, Hiromi Muta, Naohiko Harada, Kazuhiko Nakamura & Ryoichi Takayanagi

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  1. Masahiro Matsumoto
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Matsumoto, M., Yoshimura, R., Akiho, H. et al. Gastric emptying in diabetic patients by the 13C-octanoic acid breath test: role of insulin in gastric motility. J Gastroenterol 42, 469–474 (2007). https://doi.org/10.1007/s00535-007-2031-2

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