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Helicobacter pylori infection in combination with the serum pepsinogen I/II ratio and interleukin-1β-511 polymorphisms are independent risk factors for gastric cancer in Thais

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Abstract

Background

Thailand has the lowest incidence of gastric cancer in the world. Helicobacter pylori infection, a low serum pepsinogen I/II ratio, and interleukin (IL)-1β-511 polymorphisms are suspected to be risk factors for gastric cancer.

Methods

A total of 167 Thais, comprising 56 cancer patients and 111 volunteers without cancer, underwent an esophagogastroduodenoscopic examination and three fixed-point biopsies; a cancer tissue biopsy was also done, and blood samples were collected. The subjects without cancer were divided into normal subjects and chronic gastritis patients. IL-1β-511 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism, and the serum levels of pepsinogen I and II were determined by a radioimmunoassay. Helicobacter pylori IgG antibody and tissue pathology were tested in all groups.

Results

The pepsinogen I/II ratio was significantly lower in the gastric cancer group than in the normal and chronic gastritis groups [odds ratio (OR), 2.3; 95% confidence interval (CI), 1.10–4.80; P = 0.025]. Gastric cancer patients were positive for the H. pylori IgG antibody more frequently than negative (OR, 2.946; 95% CI, 1.4–6.39; P = 0.005). However, only 15 (27%) cancer patients were both positive for H. pylori IgG antibody and had low serum pepsinogen I/II. The C/C genotype was found more frequently in the gastric cancer group than in the group with a normal gastric mucosa (OR, 0.64; 95% CI, 0.50–0.81; P = 0.014).

Conclusions

A low serum pepsinogen I/II ratio combined with positivity for H. pylori IgG, and a IL-1β-511 C/C genotype may be independent risk factors for gastric cancer in Thais.

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Authors and Affiliations

  1. Division of Gastrointestinal Surgery and Endoscopy, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Sirikan Yamada

  2. Department of Gastrointestinal Endoscopy, Tama-Nagayama Hospital, Nippon Medical School, Tokyo, Japan

    Takeshi Matsuhisa

  3. Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    Luksana Makonkawkeyoon & Suparp Chaidatch

  4. Surgery for Organ Function and Biological Regulation, First Department of Surgery, Nippon Medical School, Tokyo, Japan

    Shunji Kato & Norio Matsukura

Authors
  1. Sirikan Yamada
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  2. Takeshi Matsuhisa
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  3. Luksana Makonkawkeyoon
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  4. Suparp Chaidatch
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  5. Shunji Kato
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  6. Norio Matsukura
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Additional information

Presented at the 19th World Congress of the International Society of Digestive Surgery, Pacifico Yokohama, Japan, December 8–11, 2004 (Helicobacter pylori Symposium)

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Yamada, S., Matsuhisa, T., Makonkawkeyoon, L. et al. Helicobacter pylori infection in combination with the serum pepsinogen I/II ratio and interleukin-1β-511 polymorphisms are independent risk factors for gastric cancer in Thais. J Gastroenterol 41, 1169–1177 (2006). https://doi.org/10.1007/s00535-006-1951-6

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  • DOI: https://doi.org/10.1007/s00535-006-1951-6

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