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Evaluation of mucin expression patterns in gastric borderline (group III) lesions

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Abstract

Background

Recommendations for diagnosis and treatment of gastric borderline (group III) lesions remain controversial. We examined mucin expression patterns in endoscopically resected and forceps biopsy samples.

Methods

Sixty-three gastric lesions were histopathologically identified as belonging to group III on the basis of an endoscopic forceps biopsy. All of the patients underwent endoscopic resection, and the lesions were classified into group A (final diagnosis, adenocarcinoma) or group B (final diagnosis, adenoma). Immunostaining for MUC2, MUC5AC, MUC6, and CD10 was performed and the mucin phenotype determined. An additional 26 forceps biopsy samples from the above 63 patients were similarly evaluated.

Results

The proportion of complete gastric (positive for MUC5AC and MUC6) plus gastric-predominant phenotypes was significantly higher in group A (58.0%) than in group B (18.7%) lesions (P < 0.05). The proportion of the complete intestinal (positive for MUC2 and CD10) phenotype was significantly higher in group B (68.8%) than in group A (19.4%) (P < 0.05). Similar results were also observed in the 26 forceps biopsy samples histopathologically diagnosed as group III lesions. The proportion of samples with a diffuse Ki-67 immunostaining pattern was significantly higher in group A than in group B (P < 0.05). p53 expression was significantly higher in group A (29.2%) than in group B (4.3%) (P < 0.05).

Conclusions

Immunostaining of forceps biopsy samples for the mucin phenotype may be helpful for diagnosing gastric borderline (group III) lesions.

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References

  1. InstitutionalAuthorNameJapanese Research Society for Gastric Cancer (1995) Japanese classification of gastric carcinoma Kanehara Tokyo

    Google Scholar 

  2. T Katsube S Konno K Hamaguchi T Shimakawa Y Naritaka K Ogawa et al. (2005) ArticleTitleThe efficacy of endoscopic mucosal resection in the diagnosis and treatment of group III gastric lesions Anticancer Res 25 3513–6 Occurrence Handle16101171

    PubMed  Google Scholar 

  3. RJ Schlemper RH Riddell Y Kato F Borchard HS Cooper SM Dawsey et al. (2000) ArticleTitleThe Vienna classification of gastrointestinal epithelial neoplasia Gut 47 251–5 Occurrence Handle10896917 Occurrence Handle1:STN:280:DC%2BD3cvgsVWjsA%3D%3D Occurrence Handle10.1136/gut.47.2.251

    Article  PubMed  CAS  Google Scholar 

  4. AM Fertitta U Comin V Terruzzi G Minoli A Zambelli G Cannatelli et al. (1993) ArticleTitleClinical significance of gastric dysplasia: a multicenter follow-up study. Gastrointestinal Endoscopic Pathology Study Group Endoscopy 25 265–8 Occurrence Handle8330543 Occurrence Handle1:STN:280:ByyA387mt1w%3D Occurrence Handle10.1055/s-2007-1010311

    Article  PubMed  CAS  Google Scholar 

  5. S Tsukashita R Kushima M Bamba H Sugihara T Hattori (2001) ArticleTitle MUC gene expression and histogenesis of adenocarcinoma of the stomach Int J Cancer 94 166–70 Occurrence Handle11668493 Occurrence Handle1:CAS:528:DC%2BD3MXntVGlu70%3D Occurrence Handle10.1002/ijc.1460

    Article  PubMed  CAS  Google Scholar 

  6. Y Tajima T Shimoda Y Nakanishi N Yokoyama T Tanaka K Shimizu et al. (2001) ArticleTitleGastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions Oncology 61 212–20 Occurrence Handle11574777 Occurrence Handle1:STN:280:DC%2BD3MrivVKntg%3D%3D Occurrence Handle10.1159/000055377

    Article  PubMed  CAS  Google Scholar 

  7. CA Reis L David P Correa F Carneiro C de Bolos E Garcia et al. (1999) ArticleTitleIntestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression Cancer Res 59 1003–7 Occurrence Handle10070955 Occurrence Handle1:CAS:528:DyaK1MXhslemtLc%3D

    PubMed  CAS  Google Scholar 

  8. H Shiroshita H Watanabe Y Ajioka G Watanabe K Nishikura S Kitano (2004) ArticleTitleRe-evaluation of mucin phenotypes of gastric minute well-differentiated-type adenocarcinomas using a series of HGM, MUC5AC, MUC6, M-GGMC, MUC2 and CD10 stains Pathol Int 54 311–21 Occurrence Handle15086835 Occurrence Handle1:CAS:528:DC%2BD2cXltlGjs7c%3D Occurrence Handle10.1111/j.1440-1827.2004.01625.x

    Article  PubMed  CAS  Google Scholar 

  9. YS Kim J Gum SuffixJr I Brockhausen (1996) ArticleTitleMucin glycoproteins in neoplasia Glycoconj J 13 693–707 Occurrence Handle8909996 Occurrence Handle1:CAS:528:DyaK28XmslCls7Y%3D Occurrence Handle10.1007/BF00702333

    Article  PubMed  CAS  Google Scholar 

  10. Y Endoh G Tamura T Motoyama Y Ajioka H Watanabe (1999) ArticleTitleWell-differentiated adenocarcinoma mimicking complete-type intestinal metaplasia in the stomach Hum Pathol 30 826–32 Occurrence Handle10414502 Occurrence Handle1:STN:280:DyaK1MzktFCmsA%3D%3D Occurrence Handle10.1016/S0046-8177(99)90144-2

    Article  PubMed  CAS  Google Scholar 

  11. H Ono (2005) ArticleTitleEndoscopic submucosal dissection for early gastric cancer Chin J Dig Dis 6 119–21 Occurrence Handle16045601 Occurrence Handle10.1111/j.1443-9573.2005.00206.x

    Article  PubMed  Google Scholar 

  12. H Yamamoto (2005) ArticleTitleEndoscopic submucosal dissection of early cancers and large flat adenomas Clin Gastroenterol Hepatol 3 S74–6 Occurrence Handle16013004 Occurrence Handle10.1016/S1542-3565(05)00254-5

    Article  PubMed  Google Scholar 

  13. HS Lee HK Lee HS Kim HK Yang YI Kim WH Kim (2001) ArticleTitleMUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators Cancer 92 1427–34 Occurrence Handle11745219 Occurrence Handle1:CAS:528:DC%2BD3MXnvVyhu7c%3D Occurrence Handle10.1002/1097-0142(20010915)92:6<1427::AID-CNCR1466>3.0.CO;2-L

    Article  PubMed  CAS  Google Scholar 

  14. P Kolodziejczyk T Yao M Oya S Nakamura T Utsunomiya T Ishikawa et al. (1994) ArticleTitleLong-term follow-up study of patients with gastric adenomas with malignant transformation. An immunohistochemical and histochemical analysis Cancer 74 2896–907 Occurrence Handle7954254 Occurrence Handle1:STN:280:ByqD2c3hsVU%3D Occurrence Handle10.1002/1097-0142(19941201)74:11<2896::AID-CNCR2820741103>3.0.CO;2-P

    Article  PubMed  CAS  Google Scholar 

  15. M Vieth R Kushima F Borchard M Stolte (2003) ArticleTitlePyloric gland adenoma: a clinico-pathological analysis of 90 cases Virchows Arch 442 317–21 Occurrence Handle12715167 Occurrence Handle1:STN:280:DC%2BD3s7psFKquw%3D%3D

    PubMed  CAS  Google Scholar 

  16. J Pinto-de-Sousa L David CA Reis R Gomes L Silva A Pimenta (2002) ArticleTitleMucins MUC1, MUC2, MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinoma Virchows Arch 440 304–10 Occurrence Handle11889602 Occurrence Handle1:CAS:528:DC%2BD38Xhsleksb8%3D Occurrence Handle10.1007/s00428-001-0548-y

    Article  PubMed  CAS  Google Scholar 

  17. L Setala VM Kosma P Lipponen A Naukkarinen S Nordling S Hollmen et al. (1998) ArticleTitleClinical relevance of p53 index and expression of proliferating cell nuclear antigen and Ki-67 in gastric cancer J Cancer Res Clin Oncol 124 497–502 Occurrence Handle9808424 Occurrence Handle1:CAS:528:DyaK1cXmvVGlsrY%3D Occurrence Handle10.1007/s004320050205

    Article  PubMed  CAS  Google Scholar 

  18. ME Craanen P Blok W Dekker GJ Offerhaus GN Tytgat (1995) ArticleTitleChronology of p53 protein accumulation in gastric carcinogenesis Gut 36 848–52 Occurrence Handle7615272 Occurrence Handle1:STN:280:ByqA2c%2FhvVA%3D

    PubMed  CAS  Google Scholar 

  19. M Victorzon S Nordling C Haglund J Lundin PJ Roberts (1996) ArticleTitleExpression of p53 protein as a prognostic factor in patients with gastric cancer Eur J Cancer 32A 215–20 Occurrence Handle8664030 Occurrence Handle1:STN:280:BymB2MrosFE%3D Occurrence Handle10.1016/0959-8049(95)00547-1

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan

    Hideki Minematsu, Rie Kakinoki, Akira Andoh & Yoshihide Fujiyama

  2. Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Japan

    Ryoji Kushima

  3. Division of Endoscopy, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520-2192, Japan

    Yasuharu Saito

Authors
  1. Hideki Minematsu
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  2. Yasuharu Saito
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  3. Rie Kakinoki
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  4. Akira Andoh
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  5. Ryoji Kushima
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  6. Yoshihide Fujiyama
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Minematsu, H., Saito, Y., Kakinoki, R. et al. Evaluation of mucin expression patterns in gastric borderline (group III) lesions. J Gastroenterol 41, 547–553 (2006). https://doi.org/10.1007/s00535-006-1798-x

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  • DOI: https://doi.org/10.1007/s00535-006-1798-x

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