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Prognostic effects of causative virus in hepatocellular carcinoma according to the Japan integrated staging (JIS) score

Journal of Gastroenterology volume 40, pages 972–979 (2005)Cite this article

Abstract

Background

The Japan integrated staging (JIS) score is recognized to be useful in managing hepatocellular carcinoma (HCC). We evaluated the effects of the causative virus in patients stratified by this system.

Methods

We compared clinicopathologic features, cumulative and tumor-free survival rates, and causes of death between 301 hepatitis C virus-positive patients (HCV group) and 60 hepatitis B virus-positive patients (HBV group).

Results

Among patients with low JIS scores (0 or 1), the proportions of patients with high aspartate and alanine aminotranferase activities, moderate-to-severe active hepatitis, and with cirrhosis were significantly higher in the HCV than in the HBV group. Among patients with high JIS scores (2 to 4), the proportion with moderate-to-severe active hepatitis was also significantly higher in the HCV group. In patients with low JIS scores, those in the HCV group had significantly lower tumor-free and cumulative survival rates than those in the HBV group. Although no patient in the HBV group died of causes other than liver disease (HCC or hepatic failure), some patients in the HCV group died of causes other than liver disease. The proportion of patients who died because of HCC recurrence tended to be higher among patients with high JIS scores than among patients with a low JIS score.

Conclusions

The effects of viral status on survival outcomes are greatest in patients with JIS scores of 0 or 1.

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Authors and Affiliations

  1. Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan

    Shoji Kubo, Hiromu Tanaka, Taichi Shuto, Shigekazu Takemura, Takatsugu Yamamoto, Takahiro Uenishi, Shogo Tanaka, Seikan Hai, Satoshi Yamamoto, Tsuyoshi Ichikawa & Shintaro Kodai

  2. Department of General Practice, Osaka City University Hospital, Osaka, Japan

    Kazuhiro Hirohashi

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  1. Shoji Kubo
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  2. Hiromu Tanaka
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Kubo, S., Tanaka, H., Shuto, T. et al. Prognostic effects of causative virus in hepatocellular carcinoma according to the Japan integrated staging (JIS) score. J Gastroenterol 40, 972–979 (2005). https://doi.org/10.1007/s00535-005-1681-1

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  • DOI: https://doi.org/10.1007/s00535-005-1681-1

Key words

  • hepatocellular carcinoma
  • Japan integrated staging score
  • hepatitis virus
  • liver resection