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Association between interleukin-1β-511C/T polymorphism and reflux esophagitis in Japan

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Abstract

Background

Interleukin-1β (IL-1β) gene polymorphisms are related to hypochlorhydria and increase the risk of gastric cancer in the presence of Helicobacter pylori infection. However, little information is available about the genetic risk factors of reflux esophagitis. In this study we investigated its association with the IL-1β polymorphisms.

Methods

We examined 48 patients with reflux esophagitis and 96 control subjects, 89 with gastric cancer. IL-1β-511C/T genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Results

The frequency of IL-1β-511T alleles was significantly higher in reflux esophagitis patients (57.3%) than in controls (41.1%) (P = 0.0215, χ2 = 5.289). The frequency of IL-1β-511T/T genotypes was also significantly higher in reflux esophagitis patients (31.3%) than in controls (15.6%). The odds ratio and the 95% confidence interval were 4.000 and 1.393–11.486, respectively. The frequency of IL-1β-511T/T genotypes was significantly higher in reflux esophagitis patients (31.3%) than in gastric cancer patients (21.4%). The odds ratio and the 95% confidence interval were 2.961 and 1.054–8.316, respectively.

Conclusions

IL-1β-511T was associated with reflux esophagitis having hyperacidity. Differences of genetic background regarding gastric acid secretion may exist between Japanese and Caucasians.

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References

  1. V Stanghellini (1999) ArticleTitleThree-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (Digest) Scand J Gastroenterol 231 IssueIDSuppl 20–8 Occurrence Handle10.1080/003655299750025237

    Article  Google Scholar 

  2. P Enck D Dubois P Marquis (1999) ArticleTitleQuality of life in patients with upper gastrointestinal symptoms: results from the Domestic/International Gastroenterology Surveillance Study (Digest) Scand J Gastroenterol 231 IssueIDSuppl 48–54

    Google Scholar 

  3. J Lagergren R Bergstrom A Lindgren O Nyren (1999) ArticleTitleSymptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma N Engl J Med 340 825–31 Occurrence Handle10.1056/NEJM199903183401101 Occurrence Handle10080844

    Article  PubMed  Google Scholar 

  4. M Pera AJ Cameron VF Trastek HA Carpenter AR Zinsmeister (1993) ArticleTitleIncreasing incidence of adenocarcinoma of the esophagus and esophagogastric junction Gastroenterology 104 510–3 Occurrence Handle8425693

    PubMed  Google Scholar 

  5. J Dent WJ Dodds RH Friedman T Sekiguchi WJ Hogan RC Arndorfer et al. (1980) ArticleTitleMechanism of gastroesophageal reflux in recumbent asymptomatic human subjects J Clin Invest 65 256–67 Occurrence Handle7356677

    PubMed  Google Scholar 

  6. WJ Dodds J Dent WJ Hogan JF Helm R Hauser GK Patel et al. (1982) ArticleTitleMechanisms of gastroesophageal reflux in patients with reflux esophagitis N Engl J Med 307 1547–52 Occurrence Handle7144836

    PubMed  Google Scholar 

  7. Trudgill NJ, Kapur KC, Riley SA. Familial clustering of reflux symptoms. Am J Gastroenterol 1999:1172–8

  8. AJ Cameron J Lagergren C Henriksson O Nyren GR Locke Suffix3rd NL Pedersen (2002) ArticleTitleGastroesophageal reflux disease in monozygotic and dizygotic twins Gastroenterology 122 55–9 Occurrence Handle10.1053/gast.2002.30301 Occurrence Handle11781280

    Article  PubMed  Google Scholar 

  9. I Mohammed LF Cherkas SA Riley TD Spector NJ Trudgill (2003) ArticleTitleGenetic influences in gastro-oesophageal reflux disease: a twin study Gut 52 1085–9 Occurrence Handle10.1136/gut.52.8.1085 Occurrence Handle12865263

    Article  PubMed  Google Scholar 

  10. CA Dinarello (1996) ArticleTitleBiologic basis for interleukin-1 in disease Blood 87 2095–147 Occurrence Handle8630372

    PubMed  Google Scholar 

  11. A Robert AS Olafsson C Lancaster WR Zhang (1991) ArticleTitleInterleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying Life Sci 48 123–34 Occurrence Handle10.1016/0024-3205(91)90405-Z Occurrence Handle1825231

    Article  PubMed  Google Scholar 

  12. MT Serrano AI Lanas S Lorente R Sainz (1997) ArticleTitleCytokine effects on pepsinogen secretion from human peptic cells Gut 40 42–8 Occurrence Handle9155574

    PubMed  Google Scholar 

  13. IL Beales J Calam (1998) ArticleTitleInterleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways Gut 42 227–34 Occurrence Handle9536948

    PubMed  Google Scholar 

  14. JL Wallace CM Keenan M Cucala KG Mugridge L Parente (1992) ArticleTitleMechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy Gastroenterology 102 1176–85 Occurrence Handle1348040

    PubMed  Google Scholar 

  15. RB Sartor (1994) ArticleTitleCytokines in intestinal inflammation: pathophysiological and clinical considerations Gastroenterology 106 533–9 Occurrence Handle8299918

    PubMed  Google Scholar 

  16. EM El-Omar M Carrington WH Chow KE McColl JH Bream HA Young et al. (2000) ArticleTitleInterleukin-1 polymorphisms associated with increased risk of gastric cancer Nature 404 398–402 Occurrence Handle10.1038/35006081 Occurrence Handle10746728

    Article  PubMed  Google Scholar 

  17. R Fass (2003) ArticleTitleEpidemiology and pathophysiology of symptomatic gastroesophageal reflux disease Am J Gastroenterol 98 IssueIDSuppl S2–7 Occurrence Handle10.1016/S0002-9270(03)00009-1 Occurrence Handle12644025

    Article  PubMed  Google Scholar 

  18. R Fass JJ Ofman (2002) ArticleTitleGastroesophageal reflux disease—should we adopt a new conceptual framework? Am J Gastroenterol 97 1901–9 Occurrence Handle12190152

    PubMed  Google Scholar 

  19. BJ Marshall JR Warren (1984) ArticleTitleUnidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration Lancet 1 1311–5 Occurrence Handle10.1016/S0140-6736(84)91816-6 Occurrence Handle6145023

    Article  PubMed  Google Scholar 

  20. BJ Johnston PI Reed MH Ali (1986) ArticleTitleCampylobacter-like organisms in duodenal and antral endoscopic biopsies: relationship to inflammation Gut 27 1132–7 Occurrence Handle3781324

    PubMed  Google Scholar 

  21. BJ Marshall CS Goodwin JR Warren R Murray ED Blincow SJ Blackbourn et al. (1988) ArticleTitleProspective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori Lancet 2 1437–42 Occurrence Handle10.1016/S0140-6736(88)90929-4 Occurrence Handle2904568

    Article  PubMed  Google Scholar 

  22. J Parsonnet GD Friedman DP Vandersteen Y Chang JH Vogelman N Orentreich et al. (1991) ArticleTitleHelicobacter pylori infection and the risk of gastric carcinoma N Engl J Med 325 1127–31 Occurrence Handle1891020

    PubMed  Google Scholar 

  23. A Nomura GN Stemmermann PH Chyou I Kato GI Perez-Perez MJ Blaser (1991) ArticleTitleHelicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii N Engl J Med 325 1132–6 Occurrence Handle1891021

    PubMed  Google Scholar 

  24. DY Graham (1991) ArticleTitleHelicobacter pylori: its epidemiology and its role in duodenal ulcer disease J Gastroenterol Hepatol 6 105–13 Occurrence Handle1912414

    PubMed  Google Scholar 

  25. J Parsonnet S Hansen L Rodriguez AB Gelb RA Warnke E Jellum et al. (1994) ArticleTitleHelicobacter pylori infection and gastric lymphoma N Engl J Med 330 1267–71 Occurrence Handle10.1056/NEJM199405053301803 Occurrence Handle8145781

    Article  PubMed  Google Scholar 

  26. K Haruma H Hamada M Mihara T Kamada M Yoshihara K Sumii et al. (2000) ArticleTitleNegative association between Helicobacter pylori infection and reflux esophagitis in older patients: Case-control study in Japan Helicobacter 5 24–9 Occurrence Handle10.1046/j.1523-5378.2000.00003.x Occurrence Handle10672048

    Article  PubMed  Google Scholar 

  27. AP Weston AS Badr M Topalovski R Cherian A Dixon RS Hassanein (2000) ArticleTitleProspective evaluation of the prevalence of gastric Helicobacter pylori infection in patients with GERD, Barrett's esophagus, Barrett's dysplasia, and Barrett's adenocarcinoma Am J Gastroenterol 95 387–94 Occurrence Handle10.1111/j.1572-0241.2000.01758.x Occurrence Handle10685740

    Article  PubMed  Google Scholar 

  28. R Carlsson J Dent E Bolling-Sternevald F Johnsson O Junghard K Lauritsen et al. (1998) ArticleTitleThe usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease Scand J Gastroenterol 33 1023–9 Occurrence Handle10.1080/003655298750026697 Occurrence Handle9829354

    Article  PubMed  Google Scholar 

  29. N Hamajima K Matsuo T Saito K Tajima K Okuma K Yamao et al. (2001) ArticleTitleInterleukin 1 polymorphisms, lifestyle factors, and Helicobacter pylori infection Jpn J Cancer Res 92 383–9 Occurrence Handle11346459

    PubMed  Google Scholar 

  30. S Kato M Onda S Yamada N Matsuda A Tokunaga N Matsukura (2001) ArticleTitleAssociation of the interleukin-1β genetic polymorphism and gastric cancer risk in Japanese J Gastroenterol 36 696–9 Occurrence Handle10.1007/s005350170033 Occurrence Handle11686480

    Article  PubMed  Google Scholar 

  31. FZ Hu RA Preston JC Post GJ White LW Kikuchi X Wang et al. (2000) ArticleTitleMapping of a gene for severe pediatric gastroesophageal reflux to chromosome 13q14 JAMA 284 3125–6 Occurrence Handle10.1001/jama.284.3.325

    Article  Google Scholar 

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Authors and Affiliations

  1. Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka-cho, Yoshida-gun, Fukui, 910-1193, Japan

    Atsushi Muramatsu, Takeshi Azuma, Tomoyuki Okuda, Satoko Satomi, Masahiro Ohtani, Soshoku lee, Yoshiyuki Ito & Masaru Kuriyama

  2. Department of Endoscopic Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan

    Hiroyuki Suto & Yukinao Yamazaki

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  1. Atsushi Muramatsu
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  2. Takeshi Azuma
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Muramatsu, A., Azuma, T., Okuda, T. et al. Association between interleukin-1β-511C/T polymorphism and reflux esophagitis in Japan. J Gastroenterol 40, 873–877 (2005). https://doi.org/10.1007/s00535-005-1672-2

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  • DOI: https://doi.org/10.1007/s00535-005-1672-2

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