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Generation of islets of Langerhans from adult pancreatic stem cells

  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract.

Ductal structures of the adult pancreas contain multipotent stem cells that, under controlled in vitro conditions, are able to self-renew and differentiate into functional islets of Langerhans. In vitro-generated islets, whether derived from stem cells of human, porcine, or mouse origin, exhibit temporal changes in mRNA transcripts for islet-associated markers as well as regulated insulin responses following glucose challenge. When in vitro-generated mouse islets were implanted into diabetic mice, neovascularization of the implant material occurred, followed by reversal of insulin-dependent diabetes. The possibility of growing functional islets from adult stem cells provides new opportunities to produce large numbers of islets, even autologous islets, for use as implants.

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Authors and Affiliations

  1.  Department of Pathology, Immunology and Laboratory Medicine, PO Box 100275 JHMHSC, University of Florida, Gainesville, Florida 32610, USA, , , , , , US

    Ammon B. Peck & Janet G. Cornelius

  2.  Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA, , , , , , US

    Desmond Schatz

  3.  Ixion Biotechnology, Alachua, Florida, USA, , , , , , US

    Vijayakumar K. Ramiya

Authors
  1. Ammon B. Peck
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  2. Janet G. Cornelius
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  3. Desmond Schatz
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  4. Vijayakumar K. Ramiya
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Additional information

Received: February 19, 2002 / Accepted: March 8, 2002

Offprint requests to: A.B. Peck

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Peck, A., Cornelius, J., Schatz, D. et al. Generation of islets of Langerhans from adult pancreatic stem cells. J Hep Bil Pancr Surg 9, 704–709 (2002). https://doi.org/10.1007/s005340200097

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  • DOI: https://doi.org/10.1007/s005340200097

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