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Inflammatory pseudotumors mimicking intrahepatic cholangiocarcinoma of the liver; IgG4-positivity and its clinical significance

  • Original article
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Journal of Hepato-Biliary-Pancreatic Sciences

Abstract

Background

Inflammatory pseudotumor (IPT) of the liver is a benign condition with a good prognosis. However, it is difficult to distinguish clinical and radiological findings of IPT from those of malignancies. The aims of this study are to determine the clinical, radiological, and pathological characteristics, particularly relating to the role of the autoimmune mechanism in the development of inflammatory pseudotumours (IPTs) of the liver, and to suggest appropriate diagnostic and therapeutic strategy.

Study design

The clinical, diagnostic, and pathological characteristics including IgG4 immunohistochemical stain and follow-up data of 22 IPT patients were retrospectively analyzed.

Results

The patients were 16 men and 6 women with a mean age of 59 years. Fifteen patients (68.2%) had associated biliary diseases. Of the 16 patients treated conservatively, the masses completely resolved in 10 patients, and reduced in size in 5 patients within the first 6 months. The remaining 6 patients were treated by surgical resection. IgG4 staining of 17 tissue samples from 22 patients were negative, most of the infiltrate being of fibrohistiocytic type, whereas 4 of 5 lymphoplasmacytic cells of dominant tumors show positive staining of IgG4. Although IgG4-related sclerosing cholangitis was mostly of lymphoplasmacytic type, other histological and clinical characteristics were similar in both types of IPTs.

Conclusions

IPTs of the liver can be diagnosed based on radiological and pathological findings by needle biopsy. Although the lymphoplasmacytic type of IPTs seems to correspond to IgG4-related disease, as assessed by IgG4 immunohistochemical stain, its clinical significance is unknown. Although most IPTs can be resolved with conservative therapy, surgical resection should be considered in cases of uncertain biopsy result, presumed malignant lesion, combination with other pathology, or lack of response to conservative management.

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Authors and Affiliations

  1. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Keimyung University Dongsan Medical Center, 56 Dalseong-ro, Jung-gu, Daegu, 700-712, Republic of Korea

    Keun Soo Ahn, Koo Jeong Kang, Yong Hoon Kim & Tae Jin Lim

  2. Department of Pathology, Keimyung University Dongsan Medical Center, 56 Dalseong-ro, Jung-gu, Daegu, 700-712, Republic of Korea

    Hye Ra Jung & Yu Na Kang

  3. Department of Radiology, Keimyung University Dongsan Medical Center, 56 Dalseong-ro, Jung-gu, Daegu, 700-712, Republic of Korea

    Jung Hyeok Kwon

Authors
  1. Keun Soo Ahn
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  2. Koo Jeong Kang
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  3. Yong Hoon Kim
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  4. Tae Jin Lim
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  5. Hye Ra Jung
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  6. Yu Na Kang
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  7. Jung Hyeok Kwon
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Correspondence to Koo Jeong Kang.

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Ahn, K.S., Kang, K.J., Kim, Y.H. et al. Inflammatory pseudotumors mimicking intrahepatic cholangiocarcinoma of the liver; IgG4-positivity and its clinical significance. J Hepatobiliary Pancreat Sci 19, 405–412 (2012). https://doi.org/10.1007/s00534-011-0436-z

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  • DOI: https://doi.org/10.1007/s00534-011-0436-z

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