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A comparative study of pathological staging systems in predicting recurrent hepatocellular carcinoma after liver transplantation

  • Original article
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Background/purpose

The applicability of the staging systems of hepatocellular carcinoma (HCC) to liver transplantation (LT) has not been fully evaluated. Therefore, we compared the HCC recurrence after LT as predicted by various staging systems, including the American Joint Committee on Cancer (AJCC) system 5th edition, the AJCC system 6th edition, the American Liver Tumor Study Group (ALTSG) system, and the Liver Cancer Study Group of Japan (LCSGJ) system.

Methods

A total of 108 patients who had HCC were classified according to these systems. We compared cumulative recurrence curves, recurrence-free survival curves, and overall survival curves of the systems estimated by Kaplan–Meier method. We compared cumulative event rates among different stages with the log-rank test for each staging system.

Results

The log-rank test showed that the cumulative recurrence rates were different among different stages with a statistical significance for the staging systems except for the AJCC 5th edition system. Cumulative recurrence curves by the AJCC 6th edition system and the LCSGJ system showed better visual separation than the other two systems. With respect to recurrence-free survival and overall survival, no staging systems showed significant discriminative power.

Conclusions

The current AJCC tumor-node-metastasis staging and the LCSGJ system are superior in predicting HCC recurrence after LT.

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Authors and Affiliations

  1. Laboratory of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan

    Tomoko Okuno, Tatsuaki Tsuruyama, Hironori Haga & Toshiaki Manabe

  2. Department of Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University, Konoe-cho Yoshida Sakyo-ku, Kyoto, 606-8501, Japan

    Tomoko Okuno, Tatsuaki Tsuruyama & Keiji Tamaki

  3. Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Mikiko Ueda & Yasutsugu Takada

  4. Department of Radiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Yoji Maetani

Authors
  1. Tomoko Okuno
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  2. Tatsuaki Tsuruyama
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  3. Hironori Haga
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  4. Mikiko Ueda
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  5. Yasutsugu Takada
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  6. Yoji Maetani
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  7. Toshiaki Manabe
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  8. Keiji Tamaki
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Corresponding author

Correspondence to Tomoko Okuno.

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Okuno, T., Tsuruyama, T., Haga, H. et al. A comparative study of pathological staging systems in predicting recurrent hepatocellular carcinoma after liver transplantation. J Hepatobiliary Pancreat Surg 16, 802–807 (2009). https://doi.org/10.1007/s00534-009-0110-x

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  • DOI: https://doi.org/10.1007/s00534-009-0110-x

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