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Xanthogranulomatous cholecystitis: the use of preoperative CT findings to differentiate it from gallbladder carcinoma

Journal of Hepato-Biliary-Pancreatic Surgery volume 16, pages 333–338 (2009)Cite this article

Abstract

Background and aim

A retrospective analysis was performed on 32 patients with histologically confirmed xanthogranulomatous cholecystitis (XGC) and 21 patients with gallbladder carcinoma who underwent surgical treatment between 1998 and 2007.

Methods

All patients underwent preoperative CT scanning. The CT features analyzed were: the presence of intramural hypoattenuated nodules or bands, mucosal line, the patterns of wall thickening and enhancement, and the presence of stones in the gallbladder. The variables of the CT findings with XGC were analyzed using multivariate logistic regression analysis.

Results

Intramural hypoattenuated nodules were observed in 21 patients (65%) with XGC, but in only six patients (29%) with gallbladder carcinoma (P < 0.01). The mucosal line was observed in 27 patients (84%) with XGC and in only four patients (19%) with gallbladder carcinoma (P < 0.0001). Gallstones were noted in 24 patients (75%) with XGC and five patients (24%) with gallbladder carcinoma (P < 0.001). There was no significant difference in the pattern of gallbladder wall thickening (diffuse or focal) and the presence of changes outside the gallbladder. Multivariate logistic regression analysis revealed from the CT features that the enhanced continuous mucosal line (P = 0.0013) and the presence of gallstones (P = 0.0072) were independently correlated with XGC.

Conclusion

CT features of the enhanced continuous mucosal line in a thickened gallbladder wall, together with gallstones in a patient with chronic gallbladder disease, are highly suggestive of XGC. Accurate diagnosis of XGC may therefore indicate the need to select a less aggressive surgical approach.

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Affiliations

  1. Second Department of Surgery, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama, 641-8510, Japan

    Kazuhisa Uchiyama, Satoru Ozawa, Masaki Ueno, Shinya Hayami, Seiko Hirono, Shinomi Ina, Manabu Kawai, Masaji Tani & Hiroki Yamaue

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  1. Kazuhisa Uchiyama
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  2. Satoru Ozawa
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  3. Masaki Ueno
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  4. Shinya Hayami
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  5. Seiko Hirono
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  6. Shinomi Ina
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  7. Manabu Kawai
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  8. Masaji Tani
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  9. Hiroki Yamaue
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Correspondence to Hiroki Yamaue.

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Uchiyama, K., Ozawa, S., Ueno, M. et al. Xanthogranulomatous cholecystitis: the use of preoperative CT findings to differentiate it from gallbladder carcinoma. J Hepatobiliary Pancreat Surg 16, 333–338 (2009). https://doi.org/10.1007/s00534-009-0067-9

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  • DOI: https://doi.org/10.1007/s00534-009-0067-9

Keywords

  • Xanthogranulomatous cholecystitis (XGC)
  • Gallbladder carcinoma
  • CT scan
  • FDG-PET
  • Diffusion-weighted (DW) MRI