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Acinar cell carcinomas with exophytic growth and intraductal pancreatic duct invasion: peculiar multislice computed tomographic picture

  • Case report of interest
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

On an ultrasound and multislice computed tomography (MSCT), a 76-year-old woman was found to have a huge mass lesion in the pancreatic head. MSCT showed 8.4 cm well-enhancing exophytic tumor of the pancreatic head which also protruded into the duodenum. A tongue-like protrusion into the main pancreatic duct was depicted. Laboratory data showed elevated carbohydrate antigen 19-9. Whipple’s operation was performed. The pathological diagnosis was acinar cell carcinoma (ACC) originating in the pancreatic head and directly invading through the duodenal wall and the main pancreatic duct, without any lymph node involvement. A peculiar ACC with good enhancement, exophytic picture and tongue-like protrusion into the main pancreatic duct on MSCT is presented.

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References

  1. Hashimoto M, Matsuda M, Watanabe G, Mori M, Motoi N, Nagia K, et al. Acinar cell carcinoma of the pancreas with intraductal growth: report of a case. Pancreas. 2003;26:306–12.

    Article  PubMed  Google Scholar 

  2. Chen JD, Wu MS, Tien YW, Kuo KT, Chang MC, Lin JT. Acinar cell carcinoma with hypervascularity. J Gastroenterol Hepatol. 2001;16:107–11.

    Article  PubMed  CAS  Google Scholar 

  3. Tatli S, Mortele KJ, Levy AD, Glickman JN, Ros PR, Banks PA, et al. CT and MRI features of pure acinar cell carcinoma of the pancreas in adults. AJR. 2005;184:511–9.

    PubMed  Google Scholar 

  4. Matsuyama T, Ogata S, Sugiura Y, Yoshizumi SA, Aida S, Maehara T. Acinar cell carcinoma of the pancreas eroding the pylorus and duodenal bulb. J Hepatobiliary Pancreat Surg. 2004;11:276–9.

    Article  PubMed  Google Scholar 

  5. Chiou YY, Chiang JH, Hwang JI, Yen CH, Tsay SH, Chang CY. Acinar cell carcinoma of the pancreas clinical and computed tomography manifestations. J Comput Assist Tomogr. 2004;28:180–6.

    Article  PubMed  Google Scholar 

  6. Basturk O, Zamboni G, Klimstra DS, Capelli P, Andea A, Kamel NS, et al. Intraductal and papillary variants of acinar cell carcinomas: a new addition to the challenging differential diagnosis of intraductal neoplasm. Am J Surg Pathol. 2007;31:363–70.

    Article  PubMed  Google Scholar 

  7. Toyota N, Takada T, Ammori BJ, Toida S, Haebara H. Acinar cell carcinoma of the pancreas showing finger-print-like zymogen granules by electron microscopy: immunohistochemical study. J Hepatobiliary Pancreat Surg. 2000;7:102–6.

    Article  PubMed  CAS  Google Scholar 

  8. Hartman GG, Ni H, Pickleman J. Acinar cell carcinoma of the pancreas. Arch Pathol Lab Med. 2001;125:1127–8.

    PubMed  CAS  Google Scholar 

  9. Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas, atlas of tumor pathology. Washington DC: Armed Forces Institute of Pathology; 2007. p. 204–5.

    Google Scholar 

  10. Eriguchi N, Aoyagi S, Hara M, Okuda K, Satto N, Fukuda S, et al. Large acinar cell carcinoma of the pancreas in a patient with elevated serum AFP level. J Hepatobiliary Pancreat Surg. 2000;7:222–5.

    Article  PubMed  CAS  Google Scholar 

  11. Kawakami H, Kuwatani M, Hirano S, Kondo S, Nakanishi Y, Itoh T, et al. Pancreatic endocrine tumors with intraductal growth into the main pancreatic duct and tumor thrombus within the portal vein: a case report and review of the literature. Intern med. 2006;46:273–7.

    Article  Google Scholar 

  12. Mustert BR, Stafford-Johnson DB, Francis IR. Appearance of acinar cell carcinoma of the pancreas on dual-phase CT. AJR. 1998;171:1709.

    PubMed  CAS  Google Scholar 

  13. Yamaguchi R, Okabe Y, Jimi A, Shiota K, Kodama T, Naito Y, et al. Pancreatic acinar cell carcinoma extending into the common bile duct and main pancreatic ducts. Pathol Int. 2006;56:633–7.

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Surgery, Tainan Municipal Hospital, Tainan, Taiwan

    Ta-Ming Yang

  2. Department of Diagnostic Radiology, Tainan Municipal Hospital, No. 670, Chung Te Road, Tainan, 701, Taiwan

    Shu-Chen Han

  3. Department of Pathology, Tainan Municipal Hospital, Tainan, Taiwan

    Chieh-Jen Wu

  4. Department of Gastroenterology, Tainan Municipal Hospital, Tainan, Taiwan

    Lein-Ray Mo

Authors
  1. Ta-Ming Yang
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  2. Shu-Chen Han
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  3. Chieh-Jen Wu
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Correspondence to Shu-Chen Han.

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Yang, TM., Han, SC., Wu, CJ. et al. Acinar cell carcinomas with exophytic growth and intraductal pancreatic duct invasion: peculiar multislice computed tomographic picture. J Hepatobiliary Pancreat Surg 16, 238–241 (2009). https://doi.org/10.1007/s00534-008-0034-x

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  • DOI: https://doi.org/10.1007/s00534-008-0034-x

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