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Sarcomatous hepatocellular carcinoma without previous anticancer therapy

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Journal of Hepato-Biliary-Pancreatic Surgery


Sarcomatous hepatocellular carcinoma is a rare neoplasm of the liver. A 79-year-old man with a liver tumor was admitted to our hospital. Enhanced computed tomography and magnetic resonance imaging revealed a cystlike lesion, whereas abdominal ultrasonography revealed a solid tumor. The patient underwent medial segmentectomy of the liver for the presumptive diagnosis of atypical hepatocellular carcinoma. Microscopically, the tumor was diagnosed as hepatocellular carcinoma with sarcomatous change. Although anticancer therapy is presumed to be a cause of sarcomatous change in hepatocellular carcinoma, some cases in which patients had not previously undergone anticancer therapy have been reported. Here we report a case of sarcomatous hepatocellular carcinoma without previous anticancer therapy and present a review of the literature.

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Yokomizo, J., Cho, A., Yamamoto, H. et al. Sarcomatous hepatocellular carcinoma without previous anticancer therapy. J Hepatobiliary Pancreat Surg 14, 324–327 (2007).

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