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Cystadenocarcinoma of the gallbladder

  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Biliary cystadenocarcinomas are a very rare set of neoplasms that occur in the liver, the extrahepatic bile duct system, and occasionally in the gallbladder. We report on a 75-year-old man with a cystadenocarcinoma of the gallbladder who presented with mild abdominal discomfort and a palpable mass in the right upper abdomen. The diagnostic workup included ultrasound, magnetic resonance tomography, and fine needle core biopsy and revealed a multicystic tumor 16 cm in diameter. The patient underwent multivisceral resection of the tumor with a resection of the right colon, a partial resection of the stomach and the liver, and a lymph node dissection. The resected specimen weighed 2500 g and the final histopatholical diagnosis was a primary, moderately differentiated cystadenocarcinoma of the gallbladder with two lymph node metastases and invasion of the right colon. The patient remains without evidence of recurrence 12 months after surgery. The clinical presentation, diagnosis, therapeutic options, and classification of hepatobiliary cystadenocarcinomas are discussed.

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References

  1. RA Willis (1943) ArticleTitleCarcinoma arising in congenital cysts of the liver J Pathol 50 492–5 Occurrence Handle10.1002/path.1700550414

    Article  Google Scholar 

  2. JM Lauffer HU Baer CA Maurer C Stoupsis A Zimmermann MW Buchler (1998) ArticleTitleBiliary cystadenocarcinoma of the liver: the need for complete resection Eur J Cancer 34 1845–51 Occurrence Handle10023304 Occurrence Handle1:STN:280:DyaK1M7kslertw%3D%3D Occurrence Handle10.1016/S0959-8049(98)00166-X

    Article  PubMed  CAS  Google Scholar 

  3. K Devaney ZD Goodman KG Ishak (1994) ArticleTitleHepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients Am J Surg Pathol 18 1078–91 Occurrence Handle7943529 Occurrence Handle1:STN:280:DyaK2M%2FjtVWitw%3D%3D Occurrence Handle10.1097/00000478-199411000-00002

    Article  PubMed  CAS  Google Scholar 

  4. T Terada T Takeuchi M Taniguchi (2003) ArticleTitleHepatobiliary cystadenocarcinoma with cystadenoma elements of the gall bladder in an old man Pathol Int 53 790–5 Occurrence Handle14629305 Occurrence Handle10.1046/j.1440-1827.2003.01559.x

    Article  PubMed  Google Scholar 

  5. M Matsumoto M Maruta K Maeda T Utsumi A Sugioka M Kuroda (2002) ArticleTitleEpithelial cyst of the gallbladder associated with adenocarcinoma J Hepatobiliary Pancreat Surg 9 389–92 Occurrence Handle12353154 Occurrence Handle10.1007/s005340200047

    Article  PubMed  Google Scholar 

  6. P Devine AA Ucci (1985) ArticleTitleBiliary cystadenocarcinoma arising in a congenital cyst Hum Pathol 16 92–4 Occurrence Handle3972390 Occurrence Handle1:STN:280:DyaL2M7ivFWhsQ%3D%3D

    PubMed  CAS  Google Scholar 

  7. H Richmond (1956) ArticleTitleCarcinoma arising in a congenital cyst of the liver J Pathol Bacteriol 72 681–3 Occurrence Handle10.1002/path.1700720235

    Article  Google Scholar 

  8. TC Simmons C Miller AM Pesigan KJ Lewin (1989) ArticleTitleCystadenoma of the gallbladder Am J Gastroenterol 84 1427–30 Occurrence Handle2683743 Occurrence Handle1:STN:280:DyaK3c%2FltlCktw%3D%3D

    PubMed  CAS  Google Scholar 

  9. MS Chang MC Chen FF Chou SM Sheen-Chen W Chen (1995) ArticleTitleSpontaneous rupture of hepatobiliary cystadenoma: a case report Changgeng Yi Xue Za Zhi 18 392–7 Occurrence Handle8851992 Occurrence Handle1:STN:280:DyaK2s%2FgsVKrsw%3D%3D

    PubMed  CAS  Google Scholar 

  10. Y Horsmans A Laka JF Gigot AP Geubel (1996) ArticleTitleSerum and cystic fluid CA 19-9 determinations as a diagnostic help in liver cysts of uncertain nature Liver 16 255–7 Occurrence Handle8877996 Occurrence Handle1:STN:280:DyaK2s%2Fjt1Wjsg%3D%3D

    PubMed  CAS  Google Scholar 

  11. DM Williams KM Vitellas D Sheafor (2001) ArticleTitleBiliary cystadenocarcinoma: 7 year follow-up and the role of MRI and MRCP Magn Reson Imaging 19 1203–8 Occurrence Handle11755730 Occurrence Handle1:STN:280:DC%2BD38%2FksFyhtw%3D%3D Occurrence Handle10.1016/S0730-725X(01)00453-2

    Article  PubMed  CAS  Google Scholar 

  12. PC Buetow JL Buck L Pantongrag-Brown RR Ros K Devaney ZD Goodman et al. (1995) ArticleTitleBiliary cystadenoma and cystadenocarcinoma: clinical-imaging-pathologic correlations with emphasis on the importance of ovarian stroma Radiology 196 805–10 Occurrence Handle7644647 Occurrence Handle1:STN:280:DyaK2Mznt1Ggtw%3D%3D

    PubMed  CAS  Google Scholar 

  13. S Matsumoto H Miyake H Mori (1997) ArticleTitleCase report: biliary cystadenoma with mucin-secretion mimicking a simple hepatic cyst Clin Radiol 52 316–8 Occurrence Handle9112956 Occurrence Handle1:STN:280:DyaK2s3mslKhtA%3D%3D Occurrence Handle10.1016/S0009-9260(97)80065-7

    Article  PubMed  CAS  Google Scholar 

  14. HK Wolf JA Garcia EH Bossen (1992) ArticleTitleOncocytic differentiation in intrahepatic biliary cystadenocarcinoma Mod Pathol 5 665–8 Occurrence Handle1369804 Occurrence Handle1:STN:280:DyaK2MzlslemtQ%3D%3D

    PubMed  CAS  Google Scholar 

  15. T Nakajima I Sugano O Matsuzaki K Nagao Y Kondo M Miyazaki et al. (1992) ArticleTitleBiliary cystadenocarcinoma of the liver. A clinicopathologic and histochemical evaluation of nine cases Cancer 69 2426–32 Occurrence Handle1314687 Occurrence Handle1:STN:280:DyaK383jtlensg%3D%3D Occurrence Handle10.1002/1097-0142(19920515)69:10<2426::AID-CNCR2820691007>3.0.CO;2-3

    Article  PubMed  CAS  Google Scholar 

  16. Y Iemoto Y Kondo S Fukamachi (1981) ArticleTitleBiliary cystadenocarcinoma with peritoneal carcinomatosis Cancer 48 1664–7 Occurrence Handle6269722 Occurrence Handle1:STN:280:DyaL38%2FisFartQ%3D%3D Occurrence Handle10.1002/1097-0142(19811001)48:7<1664::AID-CNCR2820480731>3.0.CO;2-O

    Article  PubMed  CAS  Google Scholar 

  17. Y Horsmans A Laka BE van Beers C Descamps JF Gigot AP Geubel (1997) ArticleTitleHepatobiliary cystadenocarcinoma without ovarian stroma and normal CA 19-9 levels. Unusually prolonged evolution Dig Dis Sci 42 1406–8 Occurrence Handle9246037 Occurrence Handle1:STN:280:DyaK2szovVyjtg%3D%3D Occurrence Handle10.1023/A:1018842021677

    Article  PubMed  CAS  Google Scholar 

  18. M Frameglia Y Nimura N Hayakawa J Kamiya S Kondo M Nagino et al. (1996) ArticleTitleBiliary cystadenocarcinoma resected by segment 3 and 4 hepatectomy Hepatogastroenterology 43 1029–34 Occurrence Handle8884334 Occurrence Handle1:STN:280:DyaK2s%2FjvVOmsQ%3D%3D

    PubMed  CAS  Google Scholar 

  19. KG Ishak (1977) ArticleTitleBiliary cystadenoma and cystadenocarcinoma: report of 14 cases and review of the literature Cancer 38 322–8 Occurrence Handle10.1002/1097-0142(197701)39:1<322::AID-CNCR2820390149>3.0.CO;2-P

    Article  Google Scholar 

  20. Siren J, Karkkainen P, Luukkonen P, Kiviluoto T, Kivilaakso. A case report of biliary cystadenoma and cystadenocarcinoma. Hepatogastroenterology 1998;45:83–9

  21. D Tsiftsis M Christodoulakis E de Bree E Sanídas et al. (1997) ArticleTitlePrimary intrahepatic biliary cystadenomatous tumors J Surg Oncol 64 341–6 Occurrence Handle9142194 Occurrence Handle1:STN:280:DyaK2s3oslWjsA%3D%3D Occurrence Handle10.1002/(SICI)1096-9098(199704)64:4<341::AID-JSO17>3.0.CO;2-5

    Article  PubMed  CAS  Google Scholar 

  22. DS Lind V Adolph GA Parker (1992) ArticleTitleMucinous biliary cystadenoma: a case report and review of the literature J Surg Oncol 51 207–10 Occurrence Handle1434648 Occurrence Handle1:STN:280:DyaK3s%2FmtFSksQ%3D%3D

    PubMed  CAS  Google Scholar 

  23. T Kosuge R Andersson S Yamazaki M Makuuchi T Takayama K Mukai et al. (1992) ArticleTitleSurgical management of biliary cystadenocarcinoma Hepatogastroenterology 39 417–9 Occurrence Handle1459521 Occurrence Handle1:STN:280:DyaK3s%2FptlGmsw%3D%3D

    PubMed  CAS  Google Scholar 

  24. L Krahenbuhl HU Baer P Renzulli K Z'Graggen E Frei MW Buchler (1996) ArticleTitleLaparoscopic management of nonparasitic symptom-producing solitary hepatic cysts J Am Coll Surg 183 493–8 Occurrence Handle8912619 Occurrence Handle1:STN:280:DyaK2s%2FmvFKgtA%3D%3D

    PubMed  CAS  Google Scholar 

  25. DA Wheeler HA Edmondson (1985) ArticleTitleCystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathologic study of 17 cases, 4 with malignant change Cancer 56 1434–45 Occurrence Handle4027877 Occurrence Handle1:STN:280:DyaL2M3otF2qsw%3D%3D Occurrence Handle10.1002/1097-0142(19850915)56:6<1434::AID-CNCR2820560635>3.0.CO;2-F

    Article  PubMed  CAS  Google Scholar 

  26. C Subramony GA Herrera EA Turbat-Herrera (1993) ArticleTitleHepatobiliary cystadenoma. A study of five cases with reference to histogenesis Arch Pathol Lab Med 117 1036–42 Occurrence Handle8215827 Occurrence Handle1:STN:280:DyaK2c%2FivFCktA%3D%3D

    PubMed  CAS  Google Scholar 

  27. S Tsukashita R Kushima M Bamba H Sugihara T Hattori (2001) ArticleTitleMUC gene expression and histogenesis of adenocarcinoma of the stomach Int J Cancer 94 166–70 Occurrence Handle11668493 Occurrence Handle1:CAS:528:DC%2BD3MXntVGlu70%3D Occurrence Handle10.1002/ijc.1460

    Article  PubMed  CAS  Google Scholar 

  28. JR Craig RL Peters HA Edmondson (1989) Tumors of the liver and the intrahepatic bile ducts. Atlas of tumor pathology, s. series Armed Forces Institute of Pathology Washington DC

    Google Scholar 

  29. T Terada Y Kitamura T Ohta Y Nakanuma (1997) ArticleTitleEndocrine cells in hepatobiliary cystadenomas and cystadenocarcinomas Virchows Arch 430 37–40 Occurrence Handle9037313 Occurrence Handle1:STN:280:DyaK2s7ovFSnsw%3D%3D Occurrence Handle10.1007/BF01008014

    Article  PubMed  CAS  Google Scholar 

  30. OE Akwari A Tucker HF Seigler KM Itani (1990) ArticleTitleHepatobiliary cystadenoma with mesenchymal stroma Ann Surg 211 18–27 Occurrence Handle2403772 Occurrence Handle1:STN:280:DyaK3c7gtlKiuw%3D%3D Occurrence Handle10.1097/00000658-199001000-00004

    Article  PubMed  CAS  Google Scholar 

  31. WK Gourley D Kumar MS Bouton JC Fish W Nealon (1992) ArticleTitleCystadenoma and cystadenocarcinoma with mesenchymal stroma of the liver. Immunohistochemical analysis Arch Pathol Lab Med 116 1047–50 Occurrence Handle1384454 Occurrence Handle1:STN:280:DyaK3s%2FjvVSmtA%3D%3D

    PubMed  CAS  Google Scholar 

  32. JL Marsh B Dahms WP Longmire SuffixJr (1974) ArticleTitleCystadenoma and cystadenocarcinoma of the biliary system Arch Surg 109 41–3 Occurrence Handle4834134 Occurrence Handle1:STN:280:DyaE2c3mtVelsg%3D%3D

    PubMed  CAS  Google Scholar 

  33. M Yamamoto S Nakajo E Tahara (1989) ArticleTitleCarcinoma of the gallbladder: the correlation between histogenesis and prognosis Virchows Arch A Pathol Anat Histopathol 414 83–90 Occurrence Handle2492696 Occurrence Handle1:STN:280:DyaL1M7jtV2hsw%3D%3D Occurrence Handle10.1007/BF00718587

    Article  PubMed  CAS  Google Scholar 

  34. M Yamamoto S Nakajo E Tahara (1989) ArticleTitleDysplasia of the gallbladder. Its histogenesis and correlation to gallbladder adenocarcinoma Pathol Res Pract 185 454–60 Occurrence Handle2602218 Occurrence Handle1:STN:280:DyaK3c%2FpvFSgtg%3D%3D

    PubMed  CAS  Google Scholar 

  35. Y Kawarada M Sanda R Mizumoto R Yatani (1986) ArticleTitleEarly carcinoma of the gallbladder, noninvasive carcinoma originating in the Rokitansky-Aschoff sinus: a case report Am J Gastroenterol 81 61–6 Occurrence Handle3942125 Occurrence Handle1:STN:280:DyaL287gtVChtA%3D%3D

    PubMed  CAS  Google Scholar 

  36. YJ Wang SD Lee KH Lai SS Wang KJ Lo (1993) ArticleTitlePrimary biliary cystic tumors of the liver Am J Gastroenterol 88 599–603 Occurrence Handle8470646 Occurrence Handle1:STN:280:DyaK3s3ivVSnsw%3D%3D

    PubMed  CAS  Google Scholar 

  37. GL Woods (1981) ArticleTitleBiliary cystadenocarcinoma: case report of hepatic malignancy originating in benign cystadenoma Cancer 47 2936–40 Occurrence Handle7260880 Occurrence Handle1:STN:280:DyaL3M3lvVeiuw%3D%3D Occurrence Handle10.1002/1097-0142(19810615)47:12<2936::AID-CNCR2820471234>3.0.CO;2-4

    Article  PubMed  CAS  Google Scholar 

  38. H Bismuth L Chiche D Castaing (1995) ArticleTitleSurgical treatment of hepatocellular carcinomas in noncirrhotic liver: experience with 68 liver resections World J Surg 19 35–41 Occurrence Handle7740808 Occurrence Handle1:STN:280:DyaK2M3lvFelsw%3D%3D Occurrence Handle10.1007/BF00316977

    Article  PubMed  CAS  Google Scholar 

  39. NS Hadjis JI Blenkharn N Alexander IS Benjamin LH Blumgart (1990) ArticleTitleOutcome of radical surgery in hilar cholangiocarcinoma Surgery 107 597–604 Occurrence Handle2162082 Occurrence Handle1:STN:280:DyaK3c3otFagsw%3D%3D

    PubMed  CAS  Google Scholar 

  40. T Kosuge M Makuuchi T Takayama J Yamamoto K Shimada S Yamasaki (1993) ArticleTitleLong-term results after resection of hepatocellular carcinoma: experience of 480 cases Hepatogastroenterology 40 328–32 Occurrence Handle8406301 Occurrence Handle1:STN:280:DyaK2c%2FhtVKksw%3D%3D

    PubMed  CAS  Google Scholar 

  41. P Neuhaus S Jonas (2000) ArticleTitleSurgery for hilar cholangiocarcinoma — the German experience J Hepatobiliary Pancreat Surg 7 142–7 Occurrence Handle10982606 Occurrence Handle1:STN:280:DC%2BD3cvotFyrug%3D%3D Occurrence Handle10.1007/s005340050168

    Article  PubMed  CAS  Google Scholar 

  42. RH Castelletto C Cobas LM Mainetti C Aramburu (1988) ArticleTitlePseudosarcomatous cystadenocarcinoma versus biliary carcinosarcoma of the liver Hum Pathol 19 1363–4 Occurrence Handle3181958 Occurrence Handle1:STN:280:DyaL1M%2Fjt1ehsg%3D%3D Occurrence Handle10.1016/S0046-8177(88)80297-1

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Philipps University of Marburg, Baldingerstrasse, D-35033, Marburg, Germany

    Jens Waldmann, Andreas Zielke, Matthias Rothmund & Peter Langer

  2. Department of Pathology, Philipps University, Marburg, Germany

    Roland Moll & Tilo Schenck zu Schweinsberg

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  1. Jens Waldmann
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  2. Andreas Zielke
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  3. Roland Moll
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  4. Tilo Schenck zu Schweinsberg
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  5. Matthias Rothmund
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  6. Peter Langer
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Waldmann, J., Zielke, A., Moll, R. et al. Cystadenocarcinoma of the gallbladder. J Hepatobiliary Pancreat Surg 13, 594–599 (2006). https://doi.org/10.1007/s00534-006-1129-x

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  • DOI: https://doi.org/10.1007/s00534-006-1129-x

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