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Analysing the localisation sites of proteins through neural networks ensembles

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Abstract

Scientists involved in the area of proteomics are currently seeking integrated, customised and validated research solutions to better expedite their work in proteomics analyses and drug discoveries. Some drugs and most of their cell targets are proteins, because proteins dictate biological phenotype. In this context, the automated analysis of protein localisation is more complex than the automated analysis of DNA sequences; nevertheless the benefits to be derived are of same or greater importance. In order to accomplish this target, the right choice of the kind of the methods for these applications, especially when the data set is drastically imbalanced, is very important and crucial. In this paper we investigate the performance of some commonly used classifiers, such as the K nearest neighbours and feed-forward neural networks with and without cross-validation, in a class of imbalanced problems from the bioinformatics domain. Furthermore, we construct ensemble-based schemes using the notion of diversity, and we empirically test their performance on the same problems. The experimental results favour the generation of neural network ensembles as these are able to produce good generalisation ability and significant improvement compared to other single classifier methods.

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Acknowledgements

We would like to thank Dr Maria Roubelakis of Oxford University for assistance in biological aspects of this work.

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  1. School of Computer Science and Information Systems, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK

    Aristoklis D. Anastasiadis & George D. Magoulas

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  1. Aristoklis D. Anastasiadis
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  2. George D. Magoulas
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Correspondence to Aristoklis D. Anastasiadis.

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Anastasiadis, A.D., Magoulas, G.D. Analysing the localisation sites of proteins through neural networks ensembles. Neural Comput & Applic 15, 277–288 (2006). https://doi.org/10.1007/s00521-006-0029-y

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