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Effect of gradient pressure therapy on the prevention of chemotherapy-induced peripheral neuropathy in patients with breast cancer

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Abstract

Purpose

To investigate the effect of gradient pressure therapy on the prevention of chemotherapy-induced peripheral neuropathy (CIPN) and improvement in activities of daily living (ADL) in patients with breast cancer.

Methods

Eighty female patients with breast cancer treated at Tangshan People’s Hospital between October 2022 and July 2023 were selected as research participants and divided into control and intervention, with 40 patients in each group. The control group received routine treatment and care, whereas the intervention group received gradient pressure therapy based on routine treatment and care. Incidence of peripheral neuropathy and the degree of impact on ADL between the two groups were compared after the intervention for cycles 2, 4, and 6.

Results

There was no significant difference in the general information between the two groups (P > 0.05). After two intervention cycles, there was no significant difference in the incidence of CIPN, various dimensions of Chemotherapy-Induced Peripheral Neuropathy Assessment Tool (CIPNAT), and total scores between the two groups (P > 0.05). After four intervention cycles, the two groups had a statistically significant difference in the incidence of CIPN, sensory dimension, general activity dimension, and total CIPNAT score (P < 0.05). After six intervention cycles, there was a significant difference in the incidence of CIPN, sensory dimension, fine activity dimension, general activity dimension, and total CIPNAT score between the two groups (P < 0.05), while there was no significant difference in the other dimensions (P > 0.05).

Conclusions

Gradient pressure therapy can effectively prevent or alleviate peripheral neuropathy in patients with breast cancer undergoing chemotherapy and improve their ability to perform ADL. Thus, it is safe, effective, and worthy of clinical application.

Trial Registration

RMYY-LLKS-2022–054.

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Data availability

The datasets generated during and/or analyzed during the current study are not publicly available due to [REASON(S) WHY DATA ARE NOT PUBLIC] but are available from the corresponding author on reasonable request.

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Funding

This study was supported by the Research Fund Project N020231807 of the Health Commission of Tangshan City, Hebei Province, and received funding from the Hebei Medical Science Research Project 2023 (20231807).

Author information

Authors and Affiliations

  1. North China University of Science and Technology, Tangshan, 063210, China

    Guo Dongxue & Li Ran

  2. Tangshan People’s Hospital, Tangshan, 063000, China

    Zhou Lizhi

  3. North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, China

    Zhao Fangfei

Authors
  1. Guo Dongxue
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  2. Zhao Fangfei
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  3. Li Ran
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  4. Zhou Lizhi
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Contributions

Guo Dongxue, Zhou Lizhi, and Zhao Fangfei conceived and designed the study. Guo Dongxue conducted data collection and data sorting and wrote the paper. Li Ran assisted with data analysis. All authors contributed to manuscript writing and finalization.

Corresponding author

Correspondence to Zhou Lizhi.

Ethics declarations

Ethics approval

The project is in line with the Declaration of Helsinki and Chinese medical ethics laws and was reviewed and approved by the Ethics Committee of Tangshan People’s Hospital (approval number: RMYY-LLKS-2022–054).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Consent for publication

All patients signed informed consent for publication.

Competing interests

The authors declare that they have no competing interests.

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Dongxue, G., Fangfei, Z., Ran, L. et al. Effect of gradient pressure therapy on the prevention of chemotherapy-induced peripheral neuropathy in patients with breast cancer. Support Care Cancer 32, 367 (2024). https://doi.org/10.1007/s00520-024-08581-5

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