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Effect of physical exercise on immune, inflammatory, cardiometabolic biomarkers, and fatty acids of breast cancer survivors: results from the MAMA_MOVE Gaia After Treatment trial

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Abstract

Purpose

Physical exercise has positive effects on clinical outcomes of breast cancer survivors such as quality of life, fatigue, anxiety, depression, body mass index, and physical fitness. We aimed to study its impact on immune, inflammatory, cardiometabolic, and fatty acids (FA) biomarkers.

Methods

An exploratory sub-analysis of the MAMA_MOVE Gaia After Treatment trial (NCT04024280, registered July 18, 2019) was performed. Blood sample collections occurred during the control phase and at eight weeks of the intervention phase. Samples were subjected to complete leukocyte counts, cytokine, and cardiometabolic marker evaluation using flow cytometry, enzyme-linked immunoassays, and gas chromatography.

Results

Ninety-three percent of the 15 participants had body mass index ≥ 25 kg/m2. We observed a decrease of the plasmatic saturated FA C20:0 [median difference − 0.08% (p = 0.048); mean difference − 0.1 (95%CI − 0.1, − 0.0)], positively associated with younger ages. A tendency to increase the saturated FA C18:0 and the ratio of unsaturated/saturated FA and a tendency to decrease neutrophils (within the normal range) and interferon-gamma were observed.

Conclusions

Positive trends of physical exercise on circulating immune cells, inflammatory cytokines, and plasmatic FA were observed. Larger studies will further elucidate the implications of physical exercise on metabolism. These exploratory findings may contribute to future hypothesis-driven research and contribute to meta-analyses.

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Data Availability

The anonymised research data will be made available upon reasonable request.

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Acknowledgements

We thank Maike Collienne for the thorough scientific and English language review and Grupo Germano de Sousa for collecting the samples and performing the measurements of glycemia, insulinemia, C-peptide, triglycerides, total, HDL and LDL cholesterol, CRP, estrogens, and basal IGF-1 with no costs.

Funding

This work was supported by Comissão de Coordenação e Desenvolvimento Regional do Centro (within the project CENTRO-01–0246-FEDER-000018); FCT – Fundação para a Ciência e Tecnologia (within the projects UIDB/04501/2020, UIDB/04106/2020, UIDP/50017/2020, LA/P/0094/2020 and UIDP/50006/2020, and AIA Ph.D. scholarship 2020.09352.BD); Fundo Europeu de Desenvolvimento Regional (within the project LISBOA-01–0145-FEDER-402–022125); and Liga Portuguesa Contra o Cancro – Núcleo regional do centro.

Liga Portuguesa Contra o Cancro – Núcleo regional do centro,Comissão de Coordenação e Desenvolvimento Regional do Centro,CENTRO-01-0246-FEDER-000018,FCT – Fundação para a Ciência e Tecnologia,UIDB/04106/2020,Ph.D. scholarship 2020.09352.BD,UIDP/50006/2020,UIDB/04501/2020,Fundo Europeu de Desenvolvimento Regional,01-0145-FEDER-402-022125

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Authors and Affiliations

  1. Medical Oncology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho (CHVNG/E), 4434-502, Vila Nova de Gaia, Portugal

    Ana Joaquim, Anabela Amarelo & Andreia Capela

  2. ONCOMOVE®—Associação de Investigação de Cuidados de Suporte em Oncologia (AICSO), 4410-406, Vila Nova de Gaia, Portugal

    Ana Joaquim, Catarina Garcia, Anabela Amarelo, Pedro Antunes, Andreia Capela, Sofia Viamonte & Alberto J. Alves

  3. Institute of Biomedicine (IBIMED), Department of Medical Sciences, University of Aveiro, 3810-193, Aveiro, Portugal

    Ana Joaquim, André Góis, Anabela Soares, Sofia Viamonte & Luisa A. Helguero

  4. Research Center in Sports Sciences Health Sciences and Human Development, University of Maia, 4475-690, Maia, Portugal

    Catarina Garcia & Alberto J. Alves

  5. Research Center in Sports Sciences Health Sciences and Human Development, University of Beira Interior, 6201-001, Covilhã, Portugal

    Pedro Antunes

  6. Department of Mathematics, University of Aveiro, 3810-193, Aveiro, Portugal

    Vera Afreixo

  7. Center for Research & Development in Mathematics and Applications (CIDMA), University of Aveiro, 3810-193, Aveiro, Portugal

    Vera Afreixo

  8. Institute of Physiology, Faculty of Medicine of the University of Lisbon and Cardiovascular Centre of the University of Lisbon, 1649-028, Lisbon, Portugal

    Vera Geraldes & Ana I. Afonso

  9. Centro de Reabilitação Do Norte, Centro Hospitalar de Vila Nova de Gaia/Espinho, 4405–565, Vila Nova de Gaia, Portugal

    Sofia Viamonte

  10. LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Mass Spectrometry Centre &, 3810-193, Aveiro, Portugal

    Helena B. Ferreira, Inês Guerra & M. Rosário Domingues

  11. Centre for Environmental and Marine Studies (CESAM), Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal

    Helena B. Ferreira, Inês Guerra & M. Rosário Domingues

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  1. Ana Joaquim
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  2. André Góis
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  3. Anabela Soares
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Contributions

Conceptualization – AA, AJ, and LAH; methodology – AJA, AJ, LAH, and VA; laboratory work – AG, AIA, AS, CG, HBF, IMSG, LH, MRD, and VG; writing (original draft preparation) – AJ; writing (review and editing) – AA, AC, AIA, AJA, LAH, MRD, PA, SV, VA, and VG; supervision – AJA and LH; project administration – AA and CG; funding acquisition – LH, MRD, and VA.

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Correspondence to Ana Joaquim.

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Joaquim, A., Góis, A., Soares, A. et al. Effect of physical exercise on immune, inflammatory, cardiometabolic biomarkers, and fatty acids of breast cancer survivors: results from the MAMA_MOVE Gaia After Treatment trial. Support Care Cancer 32, 174 (2024). https://doi.org/10.1007/s00520-024-08365-x

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