Skip to main content

Advertisement

SpringerLink
Log in

Discovering different acupoint combinations of manual or electro-acupuncture to treat chemotherapy-induced nausea and vomiting based on the complex networks analysis

  • Research
  • Published:
Supportive Care in Cancer Aims and scope Submit manuscript

Abstract

Objectives

The aim of this research was to find the acupoint combinations of manual and electro-acupuncture to treat chemotherapy-induced nausea and vomiting via the complex networks analysis.

Methods

We conducted searches using PubMed, ScienceDirect, MEDLINE, Ovid, spring, Wiley, EMBASE, the Chinese biomedicine database, VIP information network, and China National Knowledge Infrastructure from the establishment of the databases to the August, 2023. Information about titles, journals, interventions, and main acupoints was extracted using the self-established “acupoint for prevention CINV data base” powered by EpiData. According to the level of literature evidence and sample size, the clinical trials and weights of the outcome indicators including nausea/vomiting efficiency were combined. After identifying articles, literature processing and complex network analysis were conducted. The degree distribution of each node, the probability distribution of node degree, the node clustering coefficient, and the distance matrix are calculated by software.

Results

Of the 4001 screened publications, 489 were eligible after careful selection. Our result showed the acupoints ST36 and PC6 were the most common combination acupoints in both electro and manual acupuncture. In terms of efficiency, ST36, PC6, and CV12 are significantly effective acupoints for manual acupuncture, and the PC6 and ST36 are effective acupoint for electro-acupuncture.

Conclusions

We found that the near-far collocation method has been commonly used for different types of acupuncture treatment in CINV. Zhongwan, Shangwan, and Liangmen have been mainly used as local acupoints, while Neiguan, Hegu, Quchi, Zusanli, Gongsun, TaiChong, and Neiguan have been mainly used as distal acupoints. From the effect analysis, acupuncture treatment of nausea manual acupuncture effect is better; acupuncture treatment of vomiting or electro-acupuncture effect is better.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Data Availability

The data that support the findings of this study are available on request from the corresponding author upon reasonable request.

References

  1. Feyer P, Jordan K (2011) Update and new trends in antiemetic therapy: the continuing need for novel therapies. Ann Oncol 22(1):30–38

    Article  PubMed  CAS  Google Scholar 

  2. Schwartzberg LS, Modiano MR, Rapoport BL et al (2015) Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens in patients with cancer: a randomised, active-controlled, double-blind, phase 3 trial. Lancet Oncol 16(9):1071–1078

    Article  PubMed  CAS  Google Scholar 

  3. Miller M, Kearney N (2004) Chemotherapy-related nausea and vomiting - past reflections, present practice and future management. Eur J Cancer Care 13(1):71–81

    Article  CAS  Google Scholar 

  4. Viale PH, Grande C, Moore S (2012) Efficacy and cost: avoiding undertreatment of chemotherapy-induced nausea and vomiting. Clin J Oncol Nurs 16(4):E133–E141

    Article  PubMed  Google Scholar 

  5. Hesketh PJ, Grunberg SM, Gralla RJ et al (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin–the Aprepitant Protocol 052 Study Group. J Clin Oncol 21(22):4112–4119

    Article  PubMed  CAS  Google Scholar 

  6. Osaki A, Inoue K, Sakai H et al (2019) A dose-finding randomized phase II study of oral netupitant in combination with palonosetron 75 mg intravenous for the prevention of chemotherapy-induced nausea and vomiting in Japanese patients receiving highly emetogenic chemotherapy. Jpn J Clin Oncol 49(2):121–129

    Article  PubMed  Google Scholar 

  7. Greenlee H, DuPont-Reyes MJ, Balneaves LG et al (2017) Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin 67(3):194–232

    Article  PubMed  PubMed Central  Google Scholar 

  8. Shan Wang (2021) Meta analysis of acupuncture in the treatment of chemotherapy induced nausea and vomiting [D]. Beijing University of Chinese Medicine. https://doi.org/10.26973/d.cnki.gbjzu.2020.000174

  9. Singh P, Yoon SS, Kuo B (2016) Nausea: a review of pathophysiology and therapeutics. Therap Adv Gastroenterol 9(1):98–112

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. NIH consensus conference (1998) Acupuncture. JAMA 280(17):1518–1524

    Article  Google Scholar 

  11. Jiasheng L (2018) Clinical observation on the prevention and treatment of gastrointestinal reactions result from chemotherapy by acupuncture at Zusanli, Neiguan and Gongsun. Clin J Chin Med 10(25):34–36

    Google Scholar 

  12. Zhang Y, Ren Y, Li P-R, Yin Z-Y, Yue C-S, Gao J-L, Guo X-B, Xue L-J (2020) Effectiveness of acupuncture and moxibustion in improving nausea and vomiting in patients with advanced cervical cancer on concurrent chemoradiotherapy. Chin J Clin Oncol Rehabil 27(04):439–443

    Google Scholar 

  13. An Q, Chen B, Guo Y, Pan X-F, Guo Y-M (2015) A preliminary discussion on rules of clinical acupoint selection of acupuncture for the treatment of chemotherapy-induced nausea and vomiting. World J Acupunct-Moxibustion 25(02):39–44+66

    Article  Google Scholar 

  14. Lu D, Zhu S, Chen F, Lu D, He S, Wang F, Gao Y, Wang N, Jiang Z, Du Y (2018) Acupuncture treating CINV induced by cisplatin: overview of clinical research in recent five years. J Clin Acupunct Moxibustion 34(06):81–86

    CAS  Google Scholar 

  15. Pu Z-J, Ma X-P, Wang Y-J, Sun Y-P (2017) Clinical study on different acupuncture and moxibustion methods for prevention and treatment of nausea and vomiting caused by chemotherapy. Chin J Inf Tradit Chin Med 24(03):34–37

    Google Scholar 

  16. Mao JJ, Pillai GG, Andrade CJ et al (2022) Integrative oncology: addressing the global challenges of cancer prevention and treatment. CA Cancer J Clin 72(2):144–164

    Article  PubMed  Google Scholar 

  17. Yang J, Che W, Wang P, Pan Z, Xia X, Wang B, Jiang X, Wang D, Lyu Z, Pan X, Chen Z, Guo Y, Shi L, Chen B, Guo Y (2021) Study on clinical practice guidelines of acupuncture and moxibustion for preventing and treating nausea. World Chin Med 16(10):1604–1609

    Google Scholar 

  18. Hickok JT, Roscoe JA, Morrow GR et al (2005) 5-Hydroxytryptamine-receptor antagonists versus prochlorperazine for control of delayed nausea caused by doxorubicin: a URCC CCOP randomised controlled trial. Lancet Oncol 6(10):765–772

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Wen XIA, Cai-peng XU, Jian-feng XU (2017) Literature analysis of acupuncture-moxibustion in attenuating nausea and vomit induced by chemotherapy. Shanghai J Acupunct Moxibustion 36(11):1381–1386

    Google Scholar 

Download references

Funding

This work was supported by the National Natural Science Foundation of China (NSFC) No. 62071324, 82004464; The Natural Science Foundation of Tianjin No. 20JCQNJC00920; Chinese Association of Chinese Medicine Youth Talent Support Project Program No. CACM-(2022-QNRC2-A09); and Government Purchase Service in state administration of traditional chinese medicine (Standardization Project of Traditional Chinese Medicine), GZY-FJS-2023-013, Research on Evaluation System of Science and Technology of Traditional Chinese Medicine.

Author information

Authors and Affiliations

  1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300381, China

    Yang Guo, Runchen Zhang, Yupei Cheng & Yi Liu

  2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China

    Yang Guo, Runchen Zhang, Yupei Cheng, Yi Liu, Bo Chen & Yi Guo

  3. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China

    Xinmeng Guo

  4. China Academy of Chinese Medical Sciences, Beijing, 100000, China

    Dian Zeng

  5. School of Electrical and Information Engineering, Tianjin University, Tianjin, 300072, China

    Jiang Wang

  6. Department of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin, 300072, China

    Bo Chen & Yi Guo

Authors
  1. Yang Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xinmeng Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Runchen Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yupei Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yi Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dian Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jiang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Bo Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yi Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceptualization, Yi Guo and Jiang Wang; methodology, Xinmeng Guo; Investigation, Yang Guo, Runchen Zhang, Yupei Cheng, and Yi Liu; writing—original draft, Yang Guo; writing—review and editing, Dian Zeng; resources, Bo Chen; supervision, Yi Guo and Bo Chen; funding, Yi Guo. All authors reviewed the manuscript.

Corresponding authors

Correspondence to Bo Chen or Yi Guo.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethical approval and consent to participate

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Strength and limitation

• We were first using complex network analysis to analyze and count the acupoints selected for the treatment of vomiting after chemotherapy.

• A thorough literature search in multiple databases and a manual search was conducted.

• The results were limited by literature data coverage and quality.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guo, Y., Guo, X., Zhang, R. et al. Discovering different acupoint combinations of manual or electro-acupuncture to treat chemotherapy-induced nausea and vomiting based on the complex networks analysis. Support Care Cancer 32, 78 (2024). https://doi.org/10.1007/s00520-023-08289-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00520-023-08289-y

Keywords

Search

Navigation