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StrataXRT for the prevention and treatment of radiation dermatitis: a critical review

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Supportive Care in Cancer Aims and scope Submit manuscript

Abstract

Purpose

The primary objective is to systematically review primary studies, such as randomized control trials (RCTs), feasibility, exploratory, and case studies; and the secondary objective is to evaluate all secondary articles, such as reviews, guidelines, and editorials, relevant to the use of StrataXRT for the prevention and/or management of radiation dermatitis (RD) in cancer patients.

Methods

A literature search was conducted up to February 26, 2023, for articles investigating the use of StrataXRT for the prevention and treatment of RD, in the following databases: Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar. The keywords “StrataXRT”, “dermatitis”, “radiotherapy”, and “radiation” were used to identify relevant articles.

Results

Twenty-seven articles from 2018 to 2022 were identified to fulfill the inclusion criteria of this review, of which nine are primary studies and 18 are secondary papers. Significant heterogeneity was observed in the current literature studying the effects of StrataXRT, making it difficult to make cross-trial comparisons. There is a suggestion of the efficacy of StrataXRT in the prevention and treatment of RD.

Conclusion

The findings of this review recommend further adequately powered RCTs with robust methodology including patient and clinician assessments to determine the efficacy of StrataXRT in preventing and treating RD. This is essential to improve the quality of life of patients and identify which groups of patients would benefit most from StrataXRT.

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Data availability

The search strategy and results can all be found in the tables and figures in the manuscript. All included articles can be found referenced in the bioliography.

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Funding

Author Raymond J. Chan is one of the trialists for one included trial. He received funding support from Stratpharma TM for conducting the trial and education sessions. All other authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Author information

Author notes

  1. Shing Fung Lee, Raymond J. Chan, and Edward Chow contributed equally to this work as joint senior authors.

Authors and Affiliations

  1. Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

    Milena Gojsevic, Shereen Akkila, Samantha K. F. Kennedy, Saba Shariati, Thenugaa Rajeswaran & Edward Chow

  2. Department of Radiation Therapy, University of Otago, Wellington, New Zealand

    Patries Herst

  3. Department of Radiology, the University of Tokyo Hospital, Tokyo, Japan

    Mami Ogita

  4. Department of Radiation Oncology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA

    Jason C. Ye

  5. Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada

    Tara Behroozian

  6. Department of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore

    Shing Fung Lee

  7. Department of Clinical Oncology, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, Hong Kong S.A.R., China

    Shing Fung Lee

  8. Caring Futures Institute, Flinders University, Adelaide, Australia

    Raymond J. Chan

  9. Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada

    Edward Chow

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  1. Milena Gojsevic
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Contributions

M.G. performed extraction of studies, wrote the main manuscript text, and prepared all figures. S.A. performed screening, extraction, prepared all tables, and helped write the manuscript. S.S. participated in title and abstract screening, full-text screening, and resolved conflicts in screening. S.K. and T.R. helped prepare table 1 and 2 and checked data extraction. P.H., M.O., J.Y., and T.B. checked data extracted from the studies, the analysis in the manuscript, and made corrections where needed. S.L., R.C., and E.C. conceptualized this work, supervised as joint senior authors, and edited the manuscript. All authors helped to edit the manuscript and commented on previous versions of the manuscript. All authors have read and approve the final version.

Corresponding author

Correspondence to Edward Chow.

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Competing interests

E.C. received the free supply of StrataXRT in a pilot study of StrataXRT in the prevention of radiation dermatitis in breast cancer. R.C. is one of the trialists for one included trial, he received funding support from Stratpharma TM for conducting the trial and education sessions. All other authors have no relevant competing interests to disclose.

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Gojsevic, M., Akkila, S., Kennedy, S.K.F. et al. StrataXRT for the prevention and treatment of radiation dermatitis: a critical review. Support Care Cancer 31, 713 (2023). https://doi.org/10.1007/s00520-023-08190-8

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