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“Evaluation of quality of life in patients with gastric adenocarcinoma receiving chemoradiotherapy: a cross-sectional study”

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The aim of this study was to evaluate quality of life (QoL) in patients with gastric adenocarcinoma receiving adjuvant chemoradiotherapy (CRT).


The European Organization for Cancer Research and Treatment Quality of Life Questionnaire-Core 30 (QLQ-C30) and site-specific module for gastric cancer (QLQ-STO22) were administered at four time points to 156 patients admitted to Cumhuriyet University Oncology Center between 2011 and 2018.


The patient group comprised 76% men and 24% women with a median age of 61 years (range, 18–88). During CRT, 12 patients (8%) discontinued treatment, 25 (16%) lost weight, and 42 (27%) had reduced performance. There was significant worsening in QLQ-C30 global health status and all functional and symptom scale scores at CRT completion. These changes were also clinically significant except for physical functioning scores and were supported by minimal clinically important difference measurements. In the QLQ-STO22, all symptoms except dry mouth and hair loss were negatively affected at CRT completion. In general, scores were improved at 1 month after CRT and almost all scores reached baseline level by 6 months. Certain scores were more adversely affected in women (global health status, physical functioning, role functioning, fatigue, pain, and insomnia), those who lost weight during CRT (emotional functioning), and those with CRT interruption (emotional functioning and anxiety).


Although CRT reduces QoL in patients with gastric cancer, the effects tend to resolve within 6 months after completing treatment. Female sex, weight loss, and CRT interruption negatively affected some QoL scores.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.


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Authors and Affiliations



All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Mukaddes Yılmaz. The first draft of the manuscript was written by Mukaddes Yılmaz and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Mukaddes Yılmaz.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of University of Sivas Cumhuriyet (Date 19.08.2021/No. 2021–08/47).

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The authors have no relevant financial or non-financial interests to disclose.

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Yılmaz, M., Erdiş, E., Uçar, M. et al. “Evaluation of quality of life in patients with gastric adenocarcinoma receiving chemoradiotherapy: a cross-sectional study”. Support Care Cancer 31, 600 (2023).

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