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Effectiveness of mat pilates on fatigue in women with breast cancer submitted to adjuvant radiotherapy: randomized controlled clinical trial

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Abstract

Purpose

This clinical trial aimed to evaluate the influence of Mat Pilates and time on the change in fatigue scores in women with breast cancer undergoing adjuvant radiotherapy (RT). Additionally, assess the adherence and adverse effects of Mat Pilates sessions and the association of the level of physical activity with severe fatigue symptoms.

Methods

One hundred fifty-six patients with non-metastatic breast cancer were randomized to usual care or supervised Mat Pilates exercise. Fatigue and physical activity level were measured at baseline, end of RT, 30 days, 3 and 6 months after RT. The generalized estimating equation (GEE) with intention to treat was applied.

Results

A significant difference in the fatigue mean between the end of RT and the baseline was found in patients of both groups. There was no adverse effect with the practice of Mat Pilates, and it was analyzed the reduction of the symptom pain after the end of RT in women of intervention group compared to the control. There was no significant effect on fatigue between the groups. Patients with severe fatigue after 3 and 6 months of RT reported a significantly lower level of physical activity in the last periods.

Conclusion

Fatigue levels increased at the end of RT but returned to baseline values after 6 months. A lower level of physical activity was associated with severe fatigue symptoms. Mat Pilates was safe for these women and reduced the symptom pain after treatment, but it did not successfully reduce fatigue during adjuvant RT.

Registration

NCT03333993. November 7, 2017. https://clinicaltrials.gov/ct2/show/NCT03333993?term=breast+cancer&cond=pilates&draw=2&rank=1.

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Authors and Affiliations

  1. National Institute of Cancer, Cancer Hospital III (Instituto Nacional de Câncer, INCA, Hospital do Câncer III), Visconde de Santa Isabel, Rio de Janeiro, RJ, 274, Brazil

    Daniele Medeiros Torres, Kelly de Menezes Fireman & Erica Alves Nogueira Fabro

  2. National Institute of Cancer, Clinical Research Division (Instituto Nacional de Câncer, INCA, Divisão de Pesquisa Clínica), Rio de Janeiro, RJ, Brazil

    Luiz Claudio Santos Thuler & Anke Bergmann

  3. National Public Health School, Oswaldo Cruz Foundation (Escola Nacional de Saúde Pública, ENSP, Fundação Oswaldo Cruz - FIOCRUZ), Rio de Janeiro, RJ, Brazil

    Rosalina Jorge Koifman & Sabrina da Silva Santos

Authors
  1. Daniele Medeiros Torres
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  2. Kelly de Menezes Fireman
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  3. Erica Alves Nogueira Fabro
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  4. Luiz Claudio Santos Thuler
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  5. Rosalina Jorge Koifman
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  6. Anke Bergmann
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  7. Sabrina da Silva Santos
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Contributions

All authors contributed to the study conception and design. Data collections were performed by Torres D.M. and Fireman K.M. Analysis were performed by Torres D.M. and Santos S.S. The first draft of the manuscript was written by Torres D.M. and Santos S.S. All authors commented on previous versions and approved the final manuscript.

Corresponding author

Correspondence to Daniele Medeiros Torres.

Ethics declarations

Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. Registered and approved by the Institutional Review Board of INCA (CAAE: 64099717.7.0000.5274) and of the National Public Health School (CAAE: 64099717.7.3001.5240) and was registered in ClinicalTrials.gov (NCT03333993).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

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Not applicable.

Competing interests

The authors have no relevant financial or non-financial interests to disclose.

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Torres, D.M., de Menezes Fireman, K., Fabro, E.A.N. et al. Effectiveness of mat pilates on fatigue in women with breast cancer submitted to adjuvant radiotherapy: randomized controlled clinical trial. Support Care Cancer 31, 362 (2023). https://doi.org/10.1007/s00520-023-07824-1

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