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Serum diamine oxidase activity derived from response to chemotherapy affects adverse events and serum amino acid levels

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Abstract

Purpose

The relationship between activity of the small intestinal villi and the effectiveness of chemotherapy remains unclear. This study aimed to investigate how serum diamine oxidase (DAO) activity affects antitumor effects, adverse events, and amino acid absorption.

Methods

We performed a single-center prospective cohort study that enrolled 50 patients with esophageal cancer (EC) receiving docetaxel, cisplatin, and 5-fluorouracil therapy. We determined the cut-off value of serum DAO activity contributing to a response to chemotherapy using a generalized additive model. Additionally, we compared adverse events, inflammatory markers, blood amino acid levels, and quality of life between the high and low DAO activity groups during chemotherapy.

Results

The cut-off value of serum DAO activity at the first visit that contributed to a chemotherapy response was 6.5 units/L. Leukopenia and neutropenia of grade ≥ 3 were significantly higher in the DAO low (< 6.5 units/L) group (p = 0.044, 0.017, respectively). Interleukin-6 was significantly lower in the DAO high (≥ 6.5 units/L) group at the first visit and at 4 weeks after the end of chemotherapy (p = 0.039, 0.011, respectively). Glutamine was higher in the DAO high group at all measurement points during chemotherapy. Fatigue was significantly lower in the DAO high group (p = 0.001).

Conclusion

Serum DAO activity may be a predictor of the response to chemotherapy in patients with EC. The absorption capacity of amino acids was maintained in the group with high DAO activity, which may have contributed to the anti-inflammatory effect and provided a background for reducing adverse events.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery and Pediatric Surgery, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan

    Yuta Sato, Yoshihiro Tanaka, Takeharu Imai, Naoki Okumura, Nobuhisa Matsuhashi, Takao Takahashi & Kazuhiro Yoshida

  2. Department of Medical Data Science, Graduate School of Medicine, Wakayama Medical University, Wakayama, Japan

    Toshio Shimokawa

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  1. Yuta Sato
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  2. Yoshihiro Tanaka
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Contributions

All the authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Yuta Sato, Takeharu Imai, Yoshihiro Tanaka, and Toshio Shimokawa. The first draft of the manuscript was written by Yuta Sato, and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Yoshihiro Tanaka.

Ethics declarations

Ethics approval

This study was conducted in accordance with the World Medical Association Declaration of Helsinki and was registered with the University Hospital Medical Information Network (UMIN000048273). The study protocol was approved by ethics committees of Gifu University School of Medicine (ID: 2019–281), and written informed consent was obtained from all of the patients before all study-related procedures.

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Informed consent was obtained from all individual participants included in the study.

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Written informed consent was obtained from the patient for publication of this manuscript. A copy of the patient’s written consent is available for review by the Editor-in-Chief of this journal.

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The authors declare no competing interests.

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Supplementary information

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Supplementary file1 (PPTX 43 KB)

520_2022_7362_MOESM2_ESM.pptx

Supplementary file2 A cut-off value of 6.5 units/L was selected for serum DAO activity, which resulted in an adjusted odds ratio of 1.5 for the estimated GAM. (PPTX 227 KB)

Supplementary file3 (DOCX 19 KB)

Supplementary file4 (DOCX 23 KB)

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Sato, Y., Tanaka, Y., Imai, T. et al. Serum diamine oxidase activity derived from response to chemotherapy affects adverse events and serum amino acid levels. Support Care Cancer 30, 9369–9377 (2022). https://doi.org/10.1007/s00520-022-07362-2

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  • DOI: https://doi.org/10.1007/s00520-022-07362-2

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