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Factors predicting gains in moderate-to-vigorous physical activity in prostate cancer survivors on androgen deprivation therapy

Abstract

Background

Whether individual, environmental, and psychosocial factors predict changes in moderate-to-vigorous physical activity (MVPA) is poorly addressed in prostate cancer (PC) survivors undergoing androgen deprivation therapy (ADT).

Purpose

This secondary analysis of a randomized controlled trial examined changes in MVPA following a supervised personal training (PT), supervised group-based (GROUP) program, or a home-based, smartphone-assisted exercise (HOME) intervention in PC survivors on ADT and explored individual, environmental, and psychosocial predictors of MVPA.

Methods

PC survivors on ADT underwent aerobic and resistance training for 6 months via PT, GROUP, or HOME. MVPA was captured via accelerometers and the Godin Leisure-Time Exercise Questionnaire. Changes in MVPA between groups were assessed using linear regression. The following predictors of MVPA were examined using Spearman correlations: the Neighborhood Environment Walkability Scale (NEWS); the Planning, Attitudes, and Behaviours (PAB) scale; the Relatedness to Others in Physical Activity Scale (ROPAS); and individual factors at baseline.

Results

Participants (n = 37) were 69.4 ± 6.5 years old and 78.4% were on ADT for ≥ 3 months. Changes in accelerometry-based bouts and MVPA as well as self-reported MVPA did not differ between groups at 6 months. The Aesthetics domain of the NEWS questionnaire at baseline was the strongest predictor of positive MVPA changes (r = .66). Attitude (r = .64), planning (r = .57), and motivation (r = .50) at baseline were also predictive of engaging in higher MVPA throughout the intervention.

Conclusion

Changes in objective MVPA were modest. Additional emphasis on specific psychosocial and individual factors is important to inform theory-based interventions that can foster PA behavior change in PC survivors on ADT.

Registration # NCT02046837.

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Fig. 1

Data availability

De-identified data will be available from the corresponding author upon reasonable request.

Code availability

Not applicable.

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Funding

This study was funded by Prostate Cancer Canada. Prostate Cancer Canada had no role in the design of the study, collection, analysis, and interpretation of data in writing the manuscript.

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Authors and Affiliations

Authors

Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Heather Leach, Sara Durbano, Daniel Santa Mina, Catherine Sabiston, Efthymios Papadopoulos, Nicole Culos-Reed, Shabbir Alibhai, and George Tomlinson. The first draft of the manuscript was written by Efthymios Papadopoulos, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Shabbir M. H. Alibhai.

Ethics declarations

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the institutional review boards of the University Health Network and the Tom Baker Cancer Centre.

Consent to participate

Informed consent was obtained from all participants included in the study.

Consent for publication

Patients signed informed consent regarding publishing their data.

Conflict of interest

The authors declare no competing interests.

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Papadopoulos, E., Leach, H.J., Tomlinson, G. et al. Factors predicting gains in moderate-to-vigorous physical activity in prostate cancer survivors on androgen deprivation therapy. Support Care Cancer (2022). https://doi.org/10.1007/s00520-022-07300-2

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Keywords

  • Physical activity
  • Behavior change
  • Environmental predictors
  • Androgen deprivation
  • Prostate cancer