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Efficacy of combined hand exercise intervention in patients with chemotherapy-induced peripheral neuropathy: a pilot randomized controlled trial

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A Correction to this article was published on 12 March 2022

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Abstract

Purpose

Previous evidence regarding the impact of exercise interventions on chemotherapy-induced peripheral neuropathy often focuses on lower-extremity functions, such as muscle strength and balance ability, while their effects on upper extremities remain unknown. We aimed to evaluate the efficacy of combined hand exercise intervention on upper-extremity function, symptoms, and quality-of-life in patients with chemotherapy-induced peripheral neuropathy (CIPN).

Methods

After screening 341 patients, 42 were randomly assigned to either the intervention (n = 21) or control (n = 21) group. Participants were evaluated at baseline (T0) and after one (T1) and two (T2) chemotherapy cycles. The primary outcome was upper-extremity function measured using the Michigan Hand Outcomes Questionnaire (MHQ) at T2. The intention-to-treat and as-treated populations were compared using a mixed-effect model.

Results

In the intention-to-treat analysis, the decline in activities of daily living of MHQ was significantly suppressed in the intervention group compared with that in the control group at T2 (difference: 7.23; 95% confidence interval: 0.35–14.10). Similarly, in the as-treated analysis, the decline in activities of daily living of MHQ was significantly suppressed in the intervention group compared with that in the control group at T2 (difference: 13.09; 95% confidence interval: 5.68–20.49). Pain also significantly improved in the intervention group compared with that in the control group at T2 (difference: 13.21; 95% confidence interval: − 22.91 to − 3.51).

Conclusion

The combined hand exercise intervention may improve upper-extremity function, such as by suppressing decline in ADL, and reduce pain in patients with CIPN.

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Funding

This study was partially funded by the grant of the Japanese Association of Occupational Therapists.

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Authors and Affiliations

  1. Department of Rehabilitation, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan

    Yuta Ikio & Daiki Matsuda

  2. Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

    Yuta Ikio, Akira Nakashima, Daiki Matsuda, Terumitsu Sawai & Toshio Higashi

  3. School of Health Sciences, Faculty of Medicine, Shinshu University, Nagano, Japan

    Akira Sagari

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  1. Yuta Ikio
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  2. Akira Sagari
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  3. Akira Nakashima
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  6. Toshio Higashi
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Correspondence to Toshio Higashi.

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The study was approved by the hospital ethics committee before the start of the study (approval number 463). Informed consent was obtained from all individual participants included in the study.

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The original version of this article was revised. Tables 1, 2, 3 are now corrected.

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Ikio, Y., Sagari, A., Nakashima, A. et al. Efficacy of combined hand exercise intervention in patients with chemotherapy-induced peripheral neuropathy: a pilot randomized controlled trial. Support Care Cancer 30, 4981–4992 (2022). https://doi.org/10.1007/s00520-022-06846-5

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