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Nutritional status alterations after chimeric antigen receptor T cell therapy in patients with hematological malignancies: a retrospective study



The influence of innovative chimeric antigen receptor T cell (CAR-T) therapy for hematological malignancies on nutritional status remains unknown. Therefore, we aim to explore the alterations of nutritional status after CAR-T cell therapy in patients with hematological malignancies.


We retrospectively collected the data of patients with acute leukemia (AL), lymphoma, and multiple myeloma (MM), who underwent CAR-T therapy at our hospital from 2018 to 2020. The serum albumin, triglyceride, and cholesterol before and 7, 14, and 21 days after CAR-T cell infusion were compared and analyzed.


A total of 117 patients were enrolled, consisting of 39 AL, 23 lymphoma, and 55 MM patients. The baseline albumin, triglyceride, and cholesterol were 37.43 ± 5.08 mg/L, 1.63 ± 0.74 mmol/L, and 3.62 ± 1.03 mmol/L, respectively. The lowest albumin level was found at 7 days after CAR-T cell infusion compared with baseline (P < 0.001), while the levels of triglyceride increased at 14 and 21 days (P < 0.001, P = 0.036). The levels of cholesterol at 7, 14, and 21 days after CAR-T cell infusion were lower than baseline (all P < 0.05). Spearman’s correlation coefficient showed cytokine release syndrome grade was negatively correlated with the levels of albumin at 7 days and cholesterol at 21 days after CAR-T cell infusion (r =  − 0.353, P < 0.001; r =  − 0.395, P = 0.002).


The alterations of different nutrition-related biochemical parameters varied after CAR-T cell therapy. The levels of albumin and total cholesterol after CAR-T cell infusion were negatively correlated with the grade of cytokine release syndrome. Specific screening and intervention for malnutrition in patients receiving CAR-T cell therapy need to be explored in further studies.

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This work was supported by the Medical Science and Technology Project of Zhejiang Provincial Health Commission (grant no. 2021432523) and Department of Education of Zhejiang Province (grant no. Y202043556).

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Authors and Affiliations



Shuyi Ding, Lingxia Cai, Aiyun Jin, Xiaoyu Zhou, Jiali Yan, and Tingting Wang designed the study and collected the data. Linqin Wang and Houli Zhao analyzed the data and wrote the manuscript. Yongxian Hu proofread the manuscript.

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Correspondence to Yongxian Hu.

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These clinical trials were performed according to the ethical principles of the Declaration of Helsinki. Approval was granted by the Medical Ethics Committee of the First Affiliated Hospital of Medical College, Zhejiang University (ChiCTR-ORN-16008948, ChiCTR1800015575, ChiCTR-OIC-17011310, ChiCTR1800017404).

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Ding, S., Cai, L., Jin, A. et al. Nutritional status alterations after chimeric antigen receptor T cell therapy in patients with hematological malignancies: a retrospective study. Support Care Cancer 30, 3321–3327 (2022).

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  • Nutritional status
  • CAR-T therapy
  • Hematological malignancies
  • Cytokine release syndrome