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The effect of interpersonal psychotherapy on quality of life among breast cancer patients with common mental health disorder: a randomized control trial at Tikur Anbessa Specialized Hospital

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Abstract

Purpose

To determine the effect of interpersonal psychotherapy on anxiety, depression, and quality of life among breast cancer patients with mental health disorders at Tikur Anbessa Specialized Hospital, Ethiopia.

Methods

A two-arm parallel randomized controlled trial study was conducted among 114 (n = 57 intervention, and n = 57 control group) breast cancer patients with common mental health disorder at the oncology center of Tikur Anbessa Specialized Hospital. The hospital anxiety and depression measurement scale was used to assess depression and anxiety disorder and a 30-item quality of life questionnaire was used to assess the quality of life. General linear model analysis was done, confounding factors were controlled, and p < 0.05 was used to declare statistical significance.

Results

Patients in the intervention group showed a significant improvement in the anxiety (coefficient − 3.68; 95% CI − 5.67, − 1.69; p < 0.001), depression (coefficient − 3.22; 95% CI − 4.7, − 1.69; p < 0.001), physical functioning (coefficient 10.55; 95% CI 3.13, 17.98; p = 0.006), health-related quality of life (coefficient 21.85; 95% CI 14.1, 29.59; p < 0.001), insomnia (coefficient − 19.56; 95% CI − 31.87, − 7.25; p = 0.002), and fatigue (coefficient − 11.37; 95% CI − 21.49, − 1.24; p = 0.028) respectively.

Conclusions

The adapted Ethiopian version of interpersonal psychotherapy had improved anxiety, depression, and some domains of health-related quality of life. Hence, health programmers should consider incorporating it as a treatment option in oncology centers.

Trial registration number

PACTR202011629348967 granted on 20 November 2020 which was retrospectively registered.

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Data availability

The datasets generated and analyzed during the current study are available from the corresponding author on a reasonable request.

Code availability

All data generated or analyzed during the study are included in this manuscript.

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Acknowledgements

We are very much grateful to the participants and clinical psychologists for their willingness to participate in this study.

Funding

This study was funded by the Addis Ababa University, school of public health and female Cancer initiative funding, Bristol Myers through CORDAID. The funder had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript (project number: 113305.002).

Author information

Authors and Affiliations

  1. Department of Reproductive Health and Health Service Management, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia

    Winini Belay, Ababi Zergaw & Werissaw Haileselassie

  2. Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

    Mirgissa kaba

  3. Department of Pathology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

    Wajana Lako Labisso

  4. Department of Oncology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

    Wondemagegnehu Tigeneh

  5. Department of Public Health, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia

    Zekariyas Sahile

  6. Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

    Abebe Ejigu

  7. Department of Psychiatry, School of Medicine and Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

    Yonas Baheretibeb

  8. Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia

    Zenawi Hagos Gufue

Authors
  1. Winini Belay
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  2. Mirgissa kaba
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  3. Wajana Lako Labisso
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  4. Wondemagegnehu Tigeneh
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  10. Werissaw Haileselassie
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Contributions

Conceptualization: Winini Belay, Werissaw Haileselassie; methodology: Winini Belay, Mirgissa kaba, Wajana Lako, Wondemagegnehu Tigeneh, Werissaw Haileselassie, Abebe Ejigu; formal analysis and investigation: Winini Belay, Zekariyas Sahile, Werissaw Haileselassie, Wajana Lako, Wondemagegnehu Tigeneh, Mirgissa Kaba; writing—original draft preparation: Winini Belay, Werissaw Haileselassie; writing—review and editing: Mirgissa kaba, Wajana Lako, Wondemagegnehu Tigeneh, Yonas Baheretibeb, Zenawi Hagos Gufue, Abebe Ejigu, Ababi Zergaw; supervision: Winini Belay, Mirgissa kaba, Werissaw Haileselassie, Wajana Lako, Wondemagegnehu Tigeneh, Mirgissa Kaba; project administration: Winini Belay, Werissaw Haileselassie; validation: Winini Belay, Zekariyas Sahile, Werissaw Haileselassie, Yonas Baheretibebe; visualization: Winini Belay, Zekariyas Sahile, Wajana Lako; resources: Wajana Lako, Werissaw Haileselassie, Mirgissa Kaba, Wondemagegnehu Tigeneh.

Corresponding author

Correspondence to Winini Belay.

Ethics declarations

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Ethical approval was obtained from the institutional review board of the school of public health, Addis Ababa University (SPH/004/2019).

Consent to participate

The participants gave consent to participate in the study through informed written consent.

Consent for publication

The participants gave consent for publication through informed consent.

Competing interests

The authors declare no competing interests.

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Belay, W., kaba, M., Labisso, W.L. et al. The effect of interpersonal psychotherapy on quality of life among breast cancer patients with common mental health disorder: a randomized control trial at Tikur Anbessa Specialized Hospital. Support Care Cancer 30, 965–972 (2022). https://doi.org/10.1007/s00520-021-06508-y

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  • DOI: https://doi.org/10.1007/s00520-021-06508-y

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