Skip to main content
Log in

Lack of neurotoxicity after rapid clearance of high dose methotrexate followed by minimal dose folinic acid

  • Letter to the Editor
  • Published:
Supportive Care in Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Data availability

Data is transparent.

Code availability

N/A.

References

  1. Niinimaki R, Aarnivala H, Banerjee J, Pokka T, Vepsalainen K and Harila-Saari A (2010) Reduced dose folinic acid rescue after high-dose methotrexate clearance is not associated with increased toxicity in a pediatric cohort. Support Care Cancer https://doi.org/10.1007/s00520-021-06395-3

  2. Joseph Cohen Ian, Johannes Wolff (2014) How long can folinic acid rescue be delayed after high-dose methotrexate without toxicity? Pediatric Blood and Cancer 61:7–10

    Article  Google Scholar 

  3. Borsi JD, Moe PJ (1987) A comparative study on the pharmacokinetics of methotrexate in the dose range of 0.5g to 33.6 g/m2 in children with acute lymphoblastic leukemia. Cancer 60:5–13

    Article  CAS  Google Scholar 

  4. Millot F, Rubie H, Mazingue F, Mechinaud F, Thyss (1994) Cerebrospinal fluid drug levels of leukemic children receiving intravenous 5g/m2 metotrexate. Leuk Lymphoma 14:141–144

    Article  CAS  Google Scholar 

  5. Cohen IJ (2017) Neurotoxicity after high-dose methotrexate (MTX) is adequately explained by insufficient folinic acid rescue. Cancer Chemother Pharmacol 79:1057–1065

    Article  CAS  Google Scholar 

  6. Cohen IJ (2021) Folinic acid over rescue of high dose methotrexate: how problematic citations conserve discredited concepts. Medical Hypotheses https://doi.org/10.1016/J.mehy.2020.110467

  7. Borsi DJ, Wesenberg F, Stockland T, Moe PJ (1991) How much is too much? Folinic acid rescue in children with acute lymphatic leukemia. Eu J Cancer 27:1006–1009

    Article  CAS  Google Scholar 

  8. Skarby TV, Anderson H, Heldrup J et al (2006) High leukoverin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphatic leukemia. Leukemia 20:1955–1962

    Article  Google Scholar 

  9. Montour-Proulx I, Kuehn SM, Keene DL et al (2005) Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the pediatric oncology group 9605 protocol. J Child Neurol 20:129–133

    Article  Google Scholar 

  10. Bell B, Abish S, Shuster J, Camitta B (1997) Neurotoxicity (NT) in patients with standard – risk acute lymphoblastic leukemia on pediatric oncology group protocol (POG) 9405. Blood 90:559A

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ian J. Cohen.

Ethics declarations

Ethics approval

N/A.

Consent to participate

N/A.

Consent for publication

N/A.

Conflict of interest

The author declares no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cohen, I.J. Lack of neurotoxicity after rapid clearance of high dose methotrexate followed by minimal dose folinic acid. Support Care Cancer 30, 1899–1900 (2022). https://doi.org/10.1007/s00520-021-06464-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00520-021-06464-7

Navigation