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The effect of massage therapy on fatigue after chemotherapy in gastrointestinal cancer patients

Abstract

Introduction

Gastrointestinal cancer patients undergoing chemotherapy usually suffer from fatigue, which may affect different aspects of their lives.

Objective

The current study aimed to investigate the effect of massage therapy on fatigue after chemotherapy in gastrointestinal cancer patients.

Method

In this quasi-experimental study, 88 gastrointestinal cancer patients were randomly allocated into two groups of intervention and control. Patients received the chemotherapy for 3 h. The intervention group received four sessions of foot massage with an interval of 40 min during the chemotherapy. The massage duration was 7 min for each foot. Fatigue was measured using the visual analogue scale to evaluate fatigue severity just after and 24 h after the chemotherapy. Friedman and Mann–Whitney U tests were used to analyze the data.

Results

The mean age of patients was 59/18 ± 9/35, and the most common type of cancer was gastric cancer (40%). There was a significant difference in the mean score of fatigue between the two groups immediately after (P > 0.001) and 24 h after chemotherapy (P < 0.001). In the intervention group, fatigue score decreased gradually (P = 0.031), while it increased in the control group (P = 0.001).

Conclusion

This study demonstrated that foot massage, as a simple method, could reduce chemotherapy-induced fatigue.

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Fig. 1

Data availability

We retain full control of the primary data and will allow the journal to review data if requested.

Code availability

It is not applicable.

Abbreviations

NCCN:

National Comprehensive Cancer Network

WHO:

World Health Organization

VAS-F:

Visual analogue scale of fatigue

References

  1. Zendehdel K (2019) Cancer statistics in IR Iran in 2018. Basic Clin Cancer Res 11(1):2228–5466. https://doi.org/10.18502/bccr.v11i1.1645

    Article  Google Scholar 

  2. Darabi M, Lari MA, Motevalian SA, Motlagh A, Arsang-Jang S, Jaberi MK (2016) Trends in gastrointestinal cancer incidence in Iran, 2001–2010: a joinpoint analysis. Epidemiol Health 38:e2016056. https://doi.org/10.4178/epih.e

    Article  PubMed  PubMed Central  Google Scholar 

  3. Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, Jemal A, Kramer JL, Siegel RL (2019) Cancer treatment and survivorship statistics. CA Cancer J Clin 69(5):363–385. https://doi.org/10.3322/caac.21565

    Article  Google Scholar 

  4. Esmaeimzadeh N, Salahi-Moghaddam A, Khoshdel A (2015) Geographic distribution of important cancers in Iran. Hormozgan Med J 19(2):66–76 (Persian)

    Google Scholar 

  5. Atrkar-Roushan Z, Kazemnejad A, Mansour-Ghanaei F, Zayeri F (2013) Trend analysis of gastrointestinal cancer incidences in Guilan province: comparing rates over 15 years. Asian Pac J Cancer Prev 14(12):7587–7593. https://doi.org/10.7314/apjcp.2013.14.12.7587

    Article  PubMed  Google Scholar 

  6. Robison JG, Smith CL (2016) Therapeutic massage during chemotherapy and/or biotherapy infusions: patient perceptions of pain, fatigue, nausea, anxiety, and satisfaction. Clin J Oncol Nurs 20(2):E34-40. https://doi.org/10.1188/16.CJON.E34-E40

    Article  PubMed  Google Scholar 

  7. Furue H (2003) Chemotherapy cancer treatment during the past sixty years. Gan to kagaku ryoho Cancer Chemother 30(10):1404

    Google Scholar 

  8. MardanianDehkordi L, Babashahi M (2018) Evaluation of fatigue and its related factors in cancer patients undergoing chemotherapy. J Health Care 20(2):156–64 (Persian)

    Article  Google Scholar 

  9. Weis J (2011) Cancer-related fatigue: prevalence, assessment and treatment strategies. Expert Rev Pharmacoecon Outcomes Res 11(4):441–446

    Article  Google Scholar 

  10. Khatiban M, BeykMoradi A, Najafi F, Roshanaie G, PourEsmaeil Z, Ahmadi A (2013) The effect of acupressure on the fatigue of patients with cancer: a randomized clinical trial. J Res Dev Nurs Midwifery 10:36–46 (Persian)

    Google Scholar 

  11. MoghaddamTabrizi F, Gozali N, Alizadeh S (2017) The effect of energy conservation strategies on cancer-related fatigue during breast cancer chemotherapy in Urmia. J Urmia Nurs Midwifery Fac 14(10):830–836

    Google Scholar 

  12. Kampshoff CS, Chinapaw MJ, Brug J, Twisk JW, Schep G, Nijziel MR, Van Mechelen W, Buffart LM (2015) Randomized controlled trial of the effects of high intensity and low-to-moderate intensity exercise on physical fitness and fatigue in cancer survivors: results of the Resistance and Endurance exercise After ChemoTherapy (REACT) study. BMC Med 13(1):275. https://doi.org/10.1186/s12916-015-0513-2

    Article  PubMed  PubMed Central  Google Scholar 

  13. Sanford NN, Sher DJ, Ahn C, Aizer AA, Mahal BA (2019) Prevalence and nondisclosure of complementary and alternative medicine use in patients with cancer and cancer survivors in the United States. JAMA Oncol 5(5):735–737. https://doi.org/10.1001/jamaoncol.2019.0349

    Article  PubMed  PubMed Central  Google Scholar 

  14. Meleis A (2012) Theoretical Nursing development & progress. Wolters Kluwer, Philadelphia

    Google Scholar 

  15. Nasiri A, Mahmodi MA, Nobakht Z (2016) Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: a randomized controlled clinical trial. Complement Ther Clin Pract 25:75–80. https://doi.org/10.1016/j.ctcp.2016.08.002

    Article  PubMed  Google Scholar 

  16. Taghipour A, BahramiTaghanaki H, Hosienzade H, Noras M (2016) Ethical and legal challenges in complementary and alternative medicine. Iran J Med Ethics Hist Med 9(3):23–31 (Persian)

    Google Scholar 

  17. Beck MF (2016) Theory & practice of therapeutic massage. Cengage Learning, Canada

    Google Scholar 

  18. Khachian A, Amini-Behbahani F, Haghani H, Saatchi K, Moradi M (2018) The effect of aromatic oil-based effleurage massage on radiotherapy-induced fatigue in patients with cancer. Iran J Nurs 31(113):10–17. https://doi.org/10.29252/ijn.31.113.10

    Article  Google Scholar 

  19. Karagozoglu S, Kahve E (2013) Effects of back massage on chemotherapy-related fatigue and anxiety: supportive care and therapeutic touch in cancer nursing. Appl Nurs Res 26(4):210–217. https://doi.org/10.1016/j.apnr.2013.07.002

    Article  PubMed  Google Scholar 

  20. Jacobs S, Mowbray C, Cates LM, Baylor A, Gable C, Skora E, Estrada M, Cheng Y, Wang J, Lewin D (2016) Pilot study of massage to improve sleep and fatigue in hospitalized adolescents with cancer. Pediatr Blood Cancer 63(5):880–886. https://doi.org/10.1002/pbc.25902

    Article  PubMed  Google Scholar 

  21. Hasankhani H, Ghaderi F, Lakdizaji S, Nahamin M (2013) The effect of the slow-stroke back massage on fatigue of dialyzed patients. Int Res J Appl Biol Sci 4(10):3004–3008 (Persian)

    Google Scholar 

  22. Cankaya A, Saritaş S (2018) Effect of classic foot massage on vital signs, pain, and nausea/vomiting symptoms after laparoscopic cholecystectomy. Surg Laparosc Endosc Percutan Tech 28(6):359–365. https://doi.org/10.1097/SLE.0000000000000586

    Article  PubMed  Google Scholar 

  23. MaryamiI Z, Modarres M, Taavoni S, Rahimi FA (2018) The effect of foot massage on pain of patients after hysterectomy. Knowl Health 12(4):61–68 (Persian)

    Google Scholar 

  24. Rahmani A, Naseri M, Salaree MM, Nehrir B (2016) Comparing the effect of foot reflexology massage, foot bath and their combination on quality of sleep in patients with acute coronary syndrome. J Caring Sci 5(4):299–306. https://doi.org/10.15171/jcs.2016.031

    Article  PubMed  PubMed Central  Google Scholar 

  25. Mehdizadeh H, Mahmoudi G, Moslemi D, Bijani A, Jahani MA (2019) A 25-year trend in gastrointestinal cancers in northern Iran (1991–2016). Caspian J Intern Med 10(4):396. https://doi.org/10.22088/cjim.10.4.396

    Article  PubMed  PubMed Central  Google Scholar 

  26. Moradian F, Fararouei M, Karami M, Gheibi Z, Nikeghbalian Z, Akbari A, Akbari M-e (2020) Trend of geographical distribution of stomach cancer in Iran from 2004–2014. https://doi.org/10.21203/rs.3.rs-123586/v1

  27. Hesami M, Kalhor M, Roshani D, Fathi M (2019) The effect of reflexology on fatigue in cancer patients receiving chemotherapy: a randomized controlled trial. Crescent J Med Biol Sci. 6(2):151–157 (Persian)

    Google Scholar 

  28. Nourmohammadi H, Motaghi M, Borji M, Tarjoman A, Soltany B (2019) The effects of reflexology on fatigue severity of patients with cancer. Asian Pac J Cancer Prev 20(2):391. https://doi.org/10.31557/APJCP.2019.20.2.391

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kinkead B, Schettler PJ, Larson ER, Carroll D, Sharenko M, Nettles J, Edwards SA, Miller AH, Torres MA, Dulop BW (2018) Massage therapy decreases cancer-related fatigue: results from a randomized early phase trial. Cancer 124(3):546–554. https://doi.org/10.1002/cncr.31064

    Article  PubMed  Google Scholar 

  30. Izgu N, Ozdemir L, Basal FB (2019) Effect of aromatherapy massage on chemotherapy-induced peripheral neuropathic pain and fatigue in patients receiving oxaliplatin: an open label quasi–randomized controlled pilot study. Cancer nurs 42(2):139–147. https://doi.org/10.1097/NCC.0000000000000577

    Article  PubMed  Google Scholar 

  31. Ozdelikara A, Tan M (2017) The effect of reflexology on chemotherapy-induced nausea, vomiting, and fatigue in breast cancer patients. Asia Pac J Oncol Nurs 4(3):241. https://doi.org/10.4103/apjon.apjon_15_17

    Article  PubMed  PubMed Central  Google Scholar 

  32. Park H, Chun Y, Kwak S (2016) The effects of aroma hand massage on fatigue and sleeping among hospice patients. Open J Nurs 6(7):515–523. https://doi.org/10.4236/ojn.2016.67054

    Article  Google Scholar 

  33. Lee S-H, Kim J-Y, Yeo S, Kim S-H, Lim S (2015) Meta-analysis of massage therapy on cancer pain. Integr Cancer Ther 14(4):297–304. https://doi.org/10.1177/1534735415572885

    Article  PubMed  Google Scholar 

  34. Yang J-H (2005) The effects of foot reflexology on nausea, vomiting and fatigue of breast cancer patients undergoing chemotherapy. J Korean Acad Nurs 35(1):177–185. https://doi.org/10.4040/jkan.2005.35.1.177

    Article  Google Scholar 

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Acknowledgements

The authors express their thanks to Deputy of Research and Technology of Guilan University of Medical Sciences for the financial support. Also, we thank all medical and nursing staff of chemotherapy department in the Razi Hospital, where patients were recruited. Finally, the authors wish to thank all the participating patients.

Funding

This research was financially supported by Deputy of Research and Technology of Guilan University of Medical Sciences.

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Authors and Affiliations

Authors

Contributions

Conceptualization: Javad Alizadeh, Mohammad Reza Yeganeh, Moluk Pouralizadeh.

Methodology: Javad Alizadeh, Mohammad Reza Yeganeh, Moluk Pouralizadeh.

Formal analysis and investigation: Zahra Atrkar Roushan.

Writing-original draft preparation: Javad Alizadeh.

Writing-review and editing: Javad Alizadeh and Moluk Pouralizadeh.

Data collection: Javad Alizadeh and Sara Khoshamouz.

Resources: Javad Alizadeh and Moluk Pouralizadeh.

Supervision: Cyrus Gharib and Moluk Pouralizadeh.

Corresponding author

Correspondence to Moluk Pouralizadeh.

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All procedures performed in studies involving human participants were in accordance with the standards of the ethics committee of the Guilan University of Medical Sciences with ethical code: IR.GUMS. REC.1398.337 and with the Helsinki declaration.

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Each participant completed a consent form.

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Each participant completed a consent form for publication.

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The authors declare that they have no competing interests.

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Alizadeh, J., Yeganeh, M.R., Pouralizadeh, M. et al. The effect of massage therapy on fatigue after chemotherapy in gastrointestinal cancer patients. Support Care Cancer 29, 7307–7314 (2021). https://doi.org/10.1007/s00520-021-06304-8

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  • DOI: https://doi.org/10.1007/s00520-021-06304-8

Keywords

  • Massage therapy
  • Fatigue
  • Chemotherapy
  • Gastrointestinal Cancers
  • Nursing