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Low-level laser or LED photobiomodulation on oral mucositis in pediatric patients under high doses of methotrexate: prospective, randomized, controlled trial

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Abstract

Purpose

The objective of the present study was to compare the efficacy of photobiomodulation with low-level laser therapy (LLLT) or light-emitting diode therapy (LEDT) devices for the prevention and treatment of oral mucositis in pediatric patients diagnosed with acute lymphoblastic leukemia undergoing chemotherapy with high doses of methotrexate (MTX).

Methods

Eighty patients were randomly divided into two groups: LLLT and LEDT. Both protocols were applied with the same energy and radiant exposure. The protocols started in the beginning of high doses MTX and finished when the patients were discharged from the hospital or there was oral mucositis resolution. The oral mucositis was assessed during each session in accordance to the World Health Organization (WHO) score. The patients’ self-assessed pain was scored on a visual analog scale (VAS).

Results

The incidence of oral mucositis was similar to LLLT and LEDT, 10% and 12.5%, respectively. Both groups required the same number of days to reach score of zero for mucositis and pain (p > 0. 05), and there was no significant difference in mean VAS between the groups.

Conclusions

These findings suggest that LEDT has similar effects to LLLT to avoid and treat oral mucositis.

Brazilian Clinical Trial Registry with #U1111-1221-5943

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Authors and Affiliations

  1. Pediatric Oncologic Hospital “Octavio Lobo”, 1394 Quatorze de Abril side street, Belém, Pará, 66063-005, Brazil

    Douglas Magno Guimaraes & Jose Miguel Alves Junior

  2. Dental School, University Center of Pará, 927 Nove de Janeiro street, Belém, Pará, 66060-575, Brazil

    Douglas Magno Guimaraes, Tamara Melo Nunes Ota, Diego Assunção Calixto Da Silva & Fabio De Lucas Da Silva Almeida

  3. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University- UNINOVE, 249 Vergueiro street, São Paulo, São Paulo, 01504-001, Brazil

    Douglas Magno Guimaraes, Tatiana Dias Schalch, Alessandro Melo Deana & Kristianne Porta Santos Fernandes

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Correspondence to Douglas Magno Guimaraes.

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Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of the University Center of Pará (#82409317.0.0000.5169)

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Informed consent was obtained from legal guardians and individual participants included in the study.

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Patients signed informed consent regarding publishing their data and photographs.

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The authors declare no competing interests.

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Guimaraes, D.M., Ota, T.M.N., Da Silva, D.A.C. et al. Low-level laser or LED photobiomodulation on oral mucositis in pediatric patients under high doses of methotrexate: prospective, randomized, controlled trial. Support Care Cancer 29, 6441–6447 (2021). https://doi.org/10.1007/s00520-021-06206-9

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