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Cancer-related cognitive impairment in patients with non-central nervous system malignancies: an overview for oncology providers from the MASCC Neurological Complications Study Group

Abstract

Cancer-related cognitive impairment (CRCI) is commonly experienced by individuals with non-central nervous system cancers throughout the disease and treatment trajectory. CRCI can have a substantial impact on the functional ability and quality of life of patients and their families. To mitigate the impact, oncology providers must know how to identify, assess, and educate patients and caregivers. The objective of this review is to provide oncology clinicians with an overview of CRCI in the context of adults with non-central nervous system cancers, with a particular focus on current approaches in its identification, assessment, and management.

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We acknowledge the valuable contribution of Rand Ajaj, who assisted in the formatting of this manuscript for publication.

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Dr. Loprinzi reports personal fees from PledPharma, personal fees from Disarm Therapeutics, personal fees from Asahi Kasei, personal fees from Metys Pharmaceuticals, personal fees from OnQuality, personal fees from Mitsubishi Tanabe, personal fees from NKMax, personal fees from Novartis, outside the submitted work. All other authors declare that they have no conflict of interest.

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Mayo, S.J., Lustberg, M., M. Dhillon, H. et al. Cancer-related cognitive impairment in patients with non-central nervous system malignancies: an overview for oncology providers from the MASCC Neurological Complications Study Group. Support Care Cancer 29, 2821–2840 (2021). https://doi.org/10.1007/s00520-020-05860-9

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Keywords

  • Cancer-related cognitive impairment
  • Chemotherapy-related cognitive impairment
  • Cognitive functioning
  • Cognition
  • Cancer
  • CRCI