Abstract
Purpose
This retrospective study investigated the effect of perioperative oral care intervention on postoperative outcomes in patients undergoing lung cancer resection, in terms of the length of postoperative hospital stay and the incidence of postoperative respiratory infections.
Methods
In total, 585 patients underwent lung resection for lung cancer, 397 received perioperative oral care intervention, whereas the remaining 188 did not. This study retrospectively investigated the demographic and clinical characteristics (including postoperative complications and postoperative hospital stay) of each group. To determine whether perioperative oral care intervention was independently associated with either postoperative hospital stay or postoperative respiratory infections, multivariate analysis, multiple regression analysis, and multivariate logistic regression analysis were conducted.
Results
Parameters significantly associated with a prolonged postoperative hospital stay in lung cancer surgery patients were older age, postoperative complications, increased intraoperative bleeding, more invasive operative approach (e.g., open surgery), and lack of perioperative oral care intervention (standard partial regression coefficient (ß) = 0.083, p = 0.027). Furthermore, older age and longer operative time were significant independent risk factors for the occurrence of postoperative respiratory infections. Lack of perioperative oral care intervention was a potential risk factor for the occurrence of postoperative respiratory infections, although not statistically significant (odds ratio = 2.448, 95% confidence interval = 0.966–6.204, p = 0.059).
Conclusion
These results highlight the importance of perioperative oral care intervention prior to lung cancer surgery, in order to shorten postoperative hospital stay and reduce the risk of postoperative respiratory infections.
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References
Shiono S, Yoshida J, Nishimura M, Hagiwara M, Hishida T, Nitadori J, Nagai K (2007) Risk factors of postoperative respiratory infections in lung cancer surgery. J Thorac Oncol 2:34–38. https://doi.org/10.1097/JTO.0b013e31802bafb6
Lee JY, Jin SM, Lee CH, Lee BJ, Kang CH, Yim JJ, Kim YT, Yang SC, Yoo CG, Han SK, Kim JH, Shim YS, Kim YW (2011) Risk factors of postoperative pneumonia after lung cancer surgery. J Korean Med Sci 26:979–984. https://doi.org/10.3346/jkms.2011.26.8.979
Schussler O, Alifano M, Dermine H, Strano S, Casetta A, Sepulveda S, Chafik A, Coignard S, Rabbat A, Regnard JF (2006) Postoperative pneumonia after major lung resection. Am J Respir Crit Care Med 173:1161–1169. https://doi.org/10.1164/rccm.200510-1556OC
Algar FJ, Alvarez A, Salvatierra A, Baamonde C, Aranda JL, Lopez-Pujol FJ (2003) Predicting pulmonary complications after pneumonectomy for lung cancer. Eur J Cardiothorac Surg 23:201–208. https://doi.org/10.1016/s1010-7940(02)00719-4
Wang Z, Pang L, Tang J, Cheng J, Chen N, Zhou J, Liu L (2019) Video-assisted thoracoscopic surgery versus muscle-sparing thoracotomy for non-small cell lung cancer: a systematic review and meta-analysis. BMC Surg 19:144. https://doi.org/10.1186/s12893-019-0618-1
Chen FF, Zhang D, Wang YL, Xiong B (2013) Video-assisted thoracoscopic surgery lobectomy versus open lobectomy in patients with clinical stage non-small cell lung cancer: a meta-analysis. Eur J Surg Oncol 39:957–963. https://doi.org/10.1016/j.ejso.2013.06.016
Wang J, Olak J, Ultmann RE, Ferguson MK (1999) Assessment of pulmonary complications after lung resection. Ann Thorac Surg 67:1444–1447. https://doi.org/10.1016/s0003-4975(99)00255-6
Diaz-Ravetllat V, Ferrer M, Gimferrer-Garolera JM, Molins L, Torres A (2012) Risk factors of postoperative nosocomial pneumonia after resection of bronchogenic carcinoma. Respir Med 106:1463–1471. https://doi.org/10.1016/j.rmed.2012.07.008
Alifano M, Regnard JF (2010) Postoperative pneumonia in lung cancer patients: chronic obstructive pulmonary disease, preoperative bronchial colonisation and antibioprophylaxis are critical issues. Eur J Cardiothorac Surg 37:750–751. https://doi.org/10.1016/j.ejcts.2009.10.013
Vaporciyan AA, Merriman KW, Ece F, Roth JA, Smythe WR, Swisher SG, Walsh GL, Nesbitt JC, Putnam JB Jr (2002) Incidence of major pulmonary morbidity after pneumonectomy: association with timing of smoking cessation. Ann Thorac Surg 73:420–425; discussion 425-426. https://doi.org/10.1016/s0003-4975(01)03443-9
Kim HJ, Cha SI, Kim CH, Lee J, Cho JY, Lee Y, Kim GJ, Lee DH (2019) Risk factors of postoperative acute lung injury following lobectomy for nonsmall cell lung cancer. Medicine (Baltimore) 98:e15078. https://doi.org/10.1097/MD.0000000000015078
Wright CD, Gaissert HA, Grab JD, O’Brien SM, Peterson ED, Allen MS (2008) Predictors of prolonged length of stay after lobectomy for lung cancer: a Society of Thoracic Surgeons general thoracic surgery database risk-adjustment model. Ann Thorac Surg 85:1857–1865; discussion 1865. https://doi.org/10.1016/j.athoracsur.2008.03.024
Atkins BZ, Harpole DH Jr, Mangum JH, Toloza EM, D’Amico TA, Burfeind WR Jr (2007) Pulmonary segmentectomy by thoracotomy or thoracoscopy: reduced hospital length of stay with a minimally-invasive approach. Ann Thorac Surg 84:1107–1112; discussion 1112-1103. https://doi.org/10.1016/j.athoracsur.2007.05.013
Hua F, Xie H, Worthington HV, Furness S, Zhang Q, Li C (2016) Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev 10:CD008367. https://doi.org/10.1002/14651858.CD008367.pub3
Chan EY, Ruest A, Meade MO, Cook DJ (2007) Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ 334:889. https://doi.org/10.1136/bmj.39136.528160.BE
de Camargo L, da Silva SN, Chambrone L (2019) Efficacy of toothbrushing procedures performed in intensive care units in reducing the risk of ventilator-associated pneumonia: a systematic review. J Periodontal Res 54:601–611. https://doi.org/10.1111/jre.12668
Labeau SO, Van de Vyver K, Brusselaers N, Vogelaers D, Blot SI (2011) Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis. Lancet Infect Dis 11:845–854. https://doi.org/10.1016/S1473-3099(11)70127-X
Kawashita Y, Koyama Y, Kurita H, Otsuru M, Ota Y, Okura M, Horie A, Sekiya H, Umeda M (2019) Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial. Int J Oral Maxillofac Surg 48:857–864. https://doi.org/10.1016/j.ijom.2018.10.010
Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, DB MG, Migliorati C, Nicolatou-Galitis O, Peterson DE, Raber-Durlacher JE, Sonis ST, Elad S, Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in C, International Society of Oral O (2014) MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120:1453–1461. https://doi.org/10.1002/cncr.28592
Elad S, Raber-Durlacher JE, Brennan MT, Saunders DP, Mank AP, Zadik Y, Quinn B, Epstein JB, Blijlevens NM, Waltimo T, Passweg JR, Correa ME, Dahllof G, Garming-Legert KU, Logan RM, Potting CM, Shapira MY, Soga Y, Stringer J, Stokman MA, Vokurka S, Wallhult E, Yarom N, Jensen SB (2015) Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT). Support Care Cancer 23:223–236. https://doi.org/10.1007/s00520-014-2378-x
Tsuji K, Shibuya Y, Akashi M, Furudoi S, Yakushijin K, Kawamoto S, Okamura A, Matsuoka H, Komori T (2015) Prospective study of dental intervention for hematopoietic malignancy. J Dent Res 94:289–296. https://doi.org/10.1177/0022034514561768
Raber-Durlacher JE, Laheij AM, Epstein JB, Epstein M, Geerligs GM, Wolffe GN, Blijlevens NM, Donnelly JP (2013) Periodontal status and bacteremia with oral viridans streptococci and coagulase negative staphylococci in allogeneic hematopoietic stem cell transplantation recipients: a prospective observational study. Support Care Cancer 21:1621–1627. https://doi.org/10.1007/s00520-012-1706-2
Kashiwazaki H, Matsushita T, Sugita J, Shigematsu A, Kasashi K, Yamazaki Y, Kanehira T, Yamamoto S, Kondo T, Endo T, Tanaka J, Hashino S, Nishio M, Imamura M, Kitagawa Y, Inoue N (2012) Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation. Support Care Cancer 20:367–373. https://doi.org/10.1007/s00520-011-1116-x
Akashi M, Nanba N, Kusumoto J, Komori T (2019) Perioperative intervention by oral medicine team in cardiovascular surgery patients. Gen Thorac Cardiovasc Surg 67:197–202. https://doi.org/10.1007/s11748-018-1020-0
Nobuhara H, Yanamoto S, Funahara M, Matsugu Y, Hayashida S, Soutome S, Kawakita A, Ikeda S, Itamoto T, Umeda M (2018) Effect of perioperative oral management on the prevention of surgical site infection after colorectal cancer surgery: a multicenter retrospective analysis of 698 patients via analysis of covariance using propensity score. Medicine (Baltimore) 97:e12545. https://doi.org/10.1097/MD.0000000000012545
Soutome S, Yanamoto S, Funahara M, Hasegawa T, Komori T, Yamada SI, Kurita H, Yamauchi C, Shibuya Y, Kojima Y, Nakahara H, Oho T, Umeda M (2017) Effect of perioperative oral care on prevention of postoperative pneumonia associated with esophageal cancer surgery: a multicenter case-control study with propensity score matching analysis. Medicine (Baltimore) 96:e7436. https://doi.org/10.1097/MD.0000000000007436
Soutome S, Yanamoto S, Funahara M, Hasegawa T, Komori T, Oho T, Umeda M (2016) Preventive effect on post-operative pneumonia of oral health care among patients who undergo esophageal resection: a multi-center retrospective study. Surg Infect 17:479–484. https://doi.org/10.1089/sur.2015.158
Shigeishi H, Ohta K, Fujimoto S, Nakagawa T, Mizuta K, Ono S, Shimasue H, Ninomiya Y, Higashikawa K, Tada M, Ishida F, Okui G, Okumura T, Fukui A, Kubozono K, Yamamoto K, Ishida Y, Seino S, Hashikata M, Sasaki K, Naruse T, Rahman MZ, Uetsuki R, Nimiya A, Takamoto M, Dainobu K, Tokikazu T, Nishi H, Sugiyama M, Takechi M (2016) Preoperative oral health care reduces postoperative inflammation and complications in oral cancer patients. Exp Ther Med 12:1922–1928. https://doi.org/10.3892/etm.2016.3532
Akutsu Y, Matsubara H, Shuto K, Shiratori T, Uesato M, Miyazawa Y, Hoshino I, Murakami K, Usui A, Kano M, Miyauchi H (2010) Pre-operative dental brushing can reduce the risk of postoperative pneumonia in esophageal cancer patients. Surgery 147:497–502. https://doi.org/10.1016/j.surg.2009.10.048
Hiramatsu T, Sugiyama M, Kuwabara S, Tachimori Y, Nishioka M (2014) Effectiveness of an outpatient preoperative care bundle in preventing postoperative pneumonia among esophageal cancer patients. Am J Infect Control 42:385–388. https://doi.org/10.1016/j.ajic.2013.11.017
Iwata E, Hasegawa T, Yamada SI, Kawashita Y, Yoshimatsu M, Mizutani T, Nakahara H, Mori K, Shibuya Y, Kurita H, Komori T (2019) Effects of perioperative oral care on prevention of postoperative pneumonia after lung resection: multicenter retrospective study with propensity score matching analysis. Surgery 165:1003–1007. https://doi.org/10.1016/j.surg.2018.11.020
Brinkman GL, Coates EO Jr (1963) The effect of bronchitis, smoking, and occupation on ventilation. Am Rev Respir Dis 87:684–693. https://doi.org/10.1164/arrd.1963.87.5.684
Sakai H, Yamada SI, Gibo T, Yoshimura N, Nishimaki F, Kondo E, Kamata T, Kurita H (2019) A retrospective analysis of the prevalence of dental diseases in patients with digestive system cancers. Medicine (Baltimore) 98:e14771. https://doi.org/10.1097/MD.0000000000014771
Koyama T, Maeda K, Anzai H, Koganei Y, Shamoto H, Wakabayashi H (2015) Early commencement of oral intake and physical function are associated with early hospital discharge with oral intake in hospitalized elderly individuals with pneumonia. J Am Geriatr Soc 63:2183–2185. https://doi.org/10.1111/jgs.13679
Maeda K, Koga T, Akagi J (2016) Tentative nil per os leads to poor outcomes in older adults with aspiration pneumonia. Clin Nutr 35:1147–1152. https://doi.org/10.1016/j.clnu.2015.09.011
Akutsu Y, Matsubara H, Okazumi S, Shimada H, Shuto K, Shiratori T, Ochiai T (2008) Impact of preoperative dental plaque culture for predicting postoperative pneumonia in esophageal cancer patients. Dig Surg 25:93–97. https://doi.org/10.1159/000121903
Terpenning MS, Taylor GW, Lopatin DE, Kerr CK, Dominguez BL, Loesche WJ (2001) Aspiration pneumonia: dental and oral risk factors in an older veteran population. J Am Geriatr Soc 49:557–563. https://doi.org/10.1046/j.1532-5415.2001.49113.x
Imsand M, Janssens JP, Auckenthaler R, Mojon P, Budtz-Jorgensen E (2002) Bronchopneumonia and oral health in hospitalized older patients. A pilot study. Gerodontology 19:66–72. https://doi.org/10.1111/j.1741-2358.2002.00066.x
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S.I., I.Y., M.S., H.O., and M.I. designed the study. S.I. and S.T. wrote the initial draft of the manuscript. S.I. contributed to the analysis. I.Y., K.K., K.E., A.S., K.H., J.S., K.S., and K.Y. contributed to data collection and interpretation of data and assisted in the preparation of the manuscript. All authors critically reviewed the manuscript. I.Y. contributed as equal first author and equal corresponding author. All authors approved the final version of the manuscript, and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Ethics Committee of Yamagata University approved this study protocol (approval number H29-423).
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Patients were given the option to opt-out of this study online. None of the subjects declined to participate.
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Ishikawa, S., Yamamori, I., Takamori, S. et al. Evaluation of effects of perioperative oral care intervention on hospitalization stay and postoperative infection in patients undergoing lung cancer intervention. Support Care Cancer 29, 135–143 (2021). https://doi.org/10.1007/s00520-020-05450-9
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DOI: https://doi.org/10.1007/s00520-020-05450-9