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Evaluation of effects of perioperative oral care intervention on hospitalization stay and postoperative infection in patients undergoing lung cancer intervention

Supportive Care in Cancer volume 29, pages 135–143 (2021)Cite this article

Abstract

Purpose

This retrospective study investigated the effect of perioperative oral care intervention on postoperative outcomes in patients undergoing lung cancer resection, in terms of the length of postoperative hospital stay and the incidence of postoperative respiratory infections.

Methods

In total, 585 patients underwent lung resection for lung cancer, 397 received perioperative oral care intervention, whereas the remaining 188 did not. This study retrospectively investigated the demographic and clinical characteristics (including postoperative complications and postoperative hospital stay) of each group. To determine whether perioperative oral care intervention was independently associated with either postoperative hospital stay or postoperative respiratory infections, multivariate analysis, multiple regression analysis, and multivariate logistic regression analysis were conducted.

Results

Parameters significantly associated with a prolonged postoperative hospital stay in lung cancer surgery patients were older age, postoperative complications, increased intraoperative bleeding, more invasive operative approach (e.g., open surgery), and lack of perioperative oral care intervention (standard partial regression coefficient (ß) = 0.083, p = 0.027). Furthermore, older age and longer operative time were significant independent risk factors for the occurrence of postoperative respiratory infections. Lack of perioperative oral care intervention was a potential risk factor for the occurrence of postoperative respiratory infections, although not statistically significant (odds ratio = 2.448, 95% confidence interval = 0.966–6.204, p = 0.059).

Conclusion

These results highlight the importance of perioperative oral care intervention prior to lung cancer surgery, in order to shorten postoperative hospital stay and reduce the risk of postoperative respiratory infections.

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Author information

Affiliations

  1. Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan

    Shigeo Ishikawa, Iku Yamamori, Kenichiro Kitabatake, Kaoru Edamatsu, Ayako Sugano, Kazuyuki Yusa & Mitsuyoshi Iino

  2. Department of Cardiovascular, Thoracic and Pediatric Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan

    Satoshi Takamori, Hiroyuki Oizumi, Hirohisa Kato, Jun Suzuki, Kaito Sato & Mitsuaki Sadahiro

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  1. Shigeo Ishikawa
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  2. Iku Yamamori
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Contributions

S.I., I.Y., M.S., H.O., and M.I. designed the study. S.I. and S.T. wrote the initial draft of the manuscript. S.I. contributed to the analysis. I.Y., K.K., K.E., A.S., K.H., J.S., K.S., and K.Y. contributed to data collection and interpretation of data and assisted in the preparation of the manuscript. All authors critically reviewed the manuscript. I.Y. contributed as equal first author and equal corresponding author. All authors approved the final version of the manuscript, and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Corresponding author

Correspondence to Shigeo Ishikawa.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Ethics Committee of Yamagata University approved this study protocol (approval number H29-423).

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Patients were given the option to opt-out of this study online. None of the subjects declined to participate.

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Ishikawa, S., Yamamori, I., Takamori, S. et al. Evaluation of effects of perioperative oral care intervention on hospitalization stay and postoperative infection in patients undergoing lung cancer intervention. Support Care Cancer 29, 135–143 (2021). https://doi.org/10.1007/s00520-020-05450-9

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Keywords

  • Perioperative oral care intervention
  • Lung cancer
  • Length of postoperative hospital stay
  • Respiratory tract infections