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High adherence of patients with multiple myeloma who receive treatment with immunomodulatory drugs (IMIDS) in hematology/oncology group practices in Germany

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Abstract

Purpose

Immunomodulatory drugs (IMIDS) have changed the treatment and outcome of patients suffering from multiple myeloma. However, with the oral administration adherence becomes an issue. Since there is no “gold standard” in measuring adherence, we assessed the adherence of myeloma patients with the help of different data sources.

Methods

All patients who have been receiving IMIDS for at least 3 months were eligible. Computer assisted personal interviews of patients and, if possible, their caregivers were carried out. Attending oncologists evaluated the patient’s adherence with the help of a standardized questionnaire. In addition, a retrospective analysis of prescription data was conducted. All data were analyzed statistically using SPSS.

Results

One hundred myeloma patients, 35% female, 65% male, with a median age of 70 years (37–86) were interviewed. Prescription data could be evaluated in terms of adherence in 78 patients (78%), 56 caregivers could be questioned (56%). Ninety-seven percent of patients rated themselves as adherent in taking IMIDS. Data from treating oncologists, caregivers and prescriptions supported this result. IMID therapies were rated as very effective and significant, toxicities were acceptable and dosing regimens simple/uncomplicated.

Conclusions

Myeloma patients seem to be highly adherent to IMID treatments.

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Acknowledgments

Thanks to Vera Friesenhahn and Kristina Kleboth for their support in running this study and to all study nurses who carried out the interviews.

Funding

This work was supported through a restricted grant from Celgene GmbH, Germany. Celgene had no role in gathering, analyzing, or interpreting the data.

Author information

Authors and Affiliations

  1. Institut für Versorgungsforschung in der Onkologie, Koblenz, Germany

    Stefan Feiten

  2. Praxisklinik für Hämatologie und Onkologie, Koblenz, Germany

    Geothy Chakupurakal & Rudolf Weide

  3. Onkologische Schwerpunktpraxis, Speyer, Germany

    Hans Peter Feustel

  4. Onkologische Gemeinschaftspraxis, Mayen, Germany

    Michael Maasberg

  5. Onkologische Praxis, Oldenburg/Delmenhorst, Germany

    Burkhard Otremba

  6. Onkologische Praxis Dr. Ehscheidt, Neuwied, Germany

    Peter Ehscheidt

  7. Mannheimer Onkologie Praxis, Mannheim, Germany

    Manfred Hensel

  8. Onkologische Schwerpunktpraxis, Kaiserslautern, Germany

    Richard Hansen

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  1. Stefan Feiten
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Correspondence to Stefan Feiten.

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Feiten, S., Chakupurakal, G., Feustel, H.P. et al. High adherence of patients with multiple myeloma who receive treatment with immunomodulatory drugs (IMIDS) in hematology/oncology group practices in Germany. Support Care Cancer 27, 4265–4271 (2019). https://doi.org/10.1007/s00520-019-04721-4

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