Supportive Care in Cancer

, Volume 27, Issue 1, pp 87–95 | Cite as

ASCO, NCCN, MASCC/ESMO: a comparison of antiemetic guidelines for the treatment of chemotherapy-induced nausea and vomiting in adult patients

  • Yasmeen Razvi
  • Stephanie Chan
  • Thomas McFarlane
  • Erin McKenzie
  • Pearl Zaki
  • Carlo DeAngelis
  • William Pidduck
  • Ahmad Bushehri
  • Edward Chow
  • Katarzyna Joanna JerzakEmail author
Review Article


Chemotherapy-induced nausea and vomiting (CINV) is a common toxicity that may impair the quality of life of patients with a variety of early- and end-stage malignancies. In light of recent changes in the optimal management of CINV, we undertook this narrative review to compare the latest guidelines published by ASCO (2017), NCCN (2018), and MASCC/ESMO (2016). The processes undertaken by each organization to evaluate existing literature were also described. Although ASCO, NCCN, and MASCC/ESMO guidelines for the treatment and prevention of CINV share many fundamental similarities, literature surrounding low and minimal emetic risk regimens is lacking. Data regarding the use of complementary alternative medicine for CINV is particularly scarce and in need of further investigation.


Guidelines Chemotherapy-induced nausea and vomiting Prophylaxis Antiemetic 



We thank the generous support of Bratty Family Fund, Michael and Karyn Goldstein Cancer Research Fund, Joey and Mary Furfari Cancer Research Fund, Pulenzas Cancer Research Fund, Joseph and Silvana Melara Cancer Research Fund, and Ofelia Cancer Research Fund.

Compliance with ethical standards

Conflict of interest

TM attended an advisory board for Purdue Pharma. EC attended an advisory board for Purdue Pharma and served as a moderator for a Purdue Pharma dinner seminar. KJJ served as a consultant for and/or attended advisory boards for Genomic Health Inc, Novartis, Purdue Pharma and Roche.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yasmeen Razvi
    • 1
  • Stephanie Chan
    • 1
  • Thomas McFarlane
    • 1
  • Erin McKenzie
    • 1
  • Pearl Zaki
    • 1
  • Carlo DeAngelis
    • 1
  • William Pidduck
    • 1
  • Ahmad Bushehri
    • 1
  • Edward Chow
    • 1
  • Katarzyna Joanna Jerzak
    • 1
    • 2
    Email author
  1. 1.Sunnybrook Odette Cancer CentreUniversity of TorontoTorontoCanada
  2. 2.Department of Medical Oncology, Odette Cancer CentreSunnybrook Health Sciences CentreTorontoCanada

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