Taxane acute pain syndrome (TAPS) in patients receiving chemotherapy for breast or prostate cancer: a prospective multi-center study

  • R. Fernandes
  • S. Mazzarello
  • A. A. Joy
  • G. R. Pond
  • J. Hilton
  • M. F. K. Ibrahim
  • C. Canil
  • M. Ong
  • C. Stober
  • L. Vandermeer
  • B. Hutton
  • M. da Costa
  • S. Damaraju
  • Mark Clemons
Original Article

Abstract

Background

Taxane acute pain syndrome (TAPS) is characterized by myalgias and arthralgias starting 2–3 days after taxane-based chemotherapy and lasting up to 7 days. In the absence of validated tools, many studies use the presence of both the myalgia and arthralgia components of the Common Terminology Criteria for Adverse Events (CTCAE) to define TAPS. The present study prospectively evaluated the frequency, severity, and impact of TAPS in patients with breast or prostate cancer.

Patients and methods

In this prospective, non-randomized study, patients with breast or prostate cancer commencing taxane-based chemotherapy completed the CTCAE (version 4.03), the Functional Assessment of Cancer Therapy-Taxane (FACT-T), and Brief Pain Inventory (BPI) questionnaires at baseline and once between days 5 and 7 of each chemotherapy cycle.

Results

From March 2015 to April 1, 2016, 75 patients (breast n = 66, prostate n = 9) were enrolled; 83% received docetaxel and 16% paclitaxel and 1% withdrew. After the first cycle of taxane, TAPS was reported by 25/69 (36.2%) patients; a further 8/69 (18.2%) reporting TAPS after a subsequent chemotherapy treatment. Overall incidence of TAPS was 33/75 (44%). While associated with detrimental scores on FACT-T and BPI as well as increased use of analgesics in 63% (21/33) of patients with TAPS, TAPS did not lead to alterations in chemotherapy dosing.

Conclusions

TAPS is common after taxane-based chemotherapy, and its presence is associated with reduced quality of life and increased analgesic requirements. Prospective patient-reported outcome assessments are crucial to help individualize treatment strategies and improve management of TAPS.

Keywords

Taxane acute pain syndrome Taxane Quality of life Breast cancer Prostate cancer 

Notes

Acknowledgements

There was no external funding for this study. We would like to thank the patients, their families, physicians, clinical research associates, and coordinators for participating in this study. Physician accrual was the following: Dr. Clemons (37), Dr. Hilton (7), Dr. Canil (5), Dr. Ong (4), Dr. Joy (4), Dr. Gertler (3), Dr. Verma (3), Dr Au (3), and Dr Zhu (3).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Comparing tapering low dose dexamethasone to other standard of care therapies for TAPS in breast cancer patients. In: Editor (ed)^(eds) Book comparing tapering low dose dexamethasone to other standard of care therapies for TAPS in breast cancer patients. https://ClinicalTrials.gov/show/NCT03348696, City
  2. 2.
    Bahl A, Oudard S, Tombal B, Ozguroglu M, Hansen S, Kocak I, Gravis G, Devin J, Shen L, de Bono JS, Sartor AO, Investigators T (2013) Impact of cabazitaxel on 2-year survival and palliation of tumour-related pain in men with metastatic castration-resistant prostate cancer treated in the TROPIC trial. Ann Oncol 24:2402–2408CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Beusterien K, Grinspan J, Kuchuk I, Mazzarello S, Dent S, Gertler S, Bouganim N, Vandermeer L, Clemons M (2014) Use of conjoint analysis to assess breast cancer patient preferences for chemotherapy side effects. Oncologist 19:127–134CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, Barlesi F, Kohlhaufl M, Arrieta O, Burgio MA, Fayette J, Lena H, Poddubskaya E, Gerber DE, Gettinger SN, Rudin CM, Rizvi N, Crino L, Blumenschein GR Jr, Antonia SJ, Dorange C, Harbison CT, Graf Finckenstein F, Brahmer JR (2015) Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 373:1627–1639CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Cella D, Peterman A, Hudgens S, Webster K, Socinski MA (2003) Measuring the side effects of taxane therapy in oncology: the functional assesment of cancer therapy-taxane (FACT-taxane). Cancer 98:822–831CrossRefPubMedGoogle Scholar
  6. 6.
    Chiu N, Zhang L, Dent R, Giotis A, van Draanen J, Gallo-Hershberg D, Chiu L, Chow R, Wan BA, Pasetka M, Stinson J, Stacey E, Verma S, Lam H, Chow E, DeAngelis C (2018) A prospective study of docetaxel-associated pain syndrome. Support Care Cancer 26:203–211CrossRefPubMedGoogle Scholar
  7. 7.
    Chow E, Nguyen J, Zhang L, Tseng LM, Hou MF, Fairchild A, Vassiliou V, Jesus-Garcia R, Alm El-Din MA, Kumar A, Forges F, Chie WC, Bottomley A, European Organization for Research Treatment of Cancer Quality of Life G (2012) International field testing of the reliability and validity of the EORTC QLQ-BM22 module to assess health-related quality of life in patients with bone metastases. Cancer 118:1457–1465CrossRefPubMedGoogle Scholar
  8. 8.
    Clinicaltrials.gov Taxane Acute Pain Syndrome (TAPS) in Patients Receiving Taxane Chemotherapy for Breast or Prostate Cancer (TAPS OTT14–06). In: Editor (ed)^(eds) Book Taxane Acute Pain Syndrome (TAPS) in Patients Receiving Taxane Chemotherapy for Breast or Prostate Cancer (TAPS OTT14–06). City
  9. 9.
    CS C (1991) Pain assessment in cancer. CRC Press, Inc, Boca RatonGoogle Scholar
  10. 10.
    Damaraju SGS, Tuszynski J, Greiner R et al (2010) CYP3A5*3 (rs776746) is associated with docetaxel-specific toxicities during adjuvant breast cancer chemotherapy. Eur J Cancer 8:175CrossRefGoogle Scholar
  11. 11.
    Damaraju SSB, Ghosh S, Pituskin E, Tuszynski J, Cass CE, Mackey JR (2010) Polymorphisms associated with toxicity from adjuvant docetaxel. Cancer Res 70:258CrossRefGoogle Scholar
  12. 12.
    Dumontet C, Jordan MA (2010) Microtubule-binding agents: a dynamic field of cancer therapeutics. Nat Rev Drug Discov 9:790–803CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Fernandes R, Mazzarello S, Hutton B, Shorr R, Majeed H, Ibrahim MF, Jacobs C, Ong M, Clemons M (2016) Taxane acute pain syndrome (TAPS) in patients receiving taxane-based chemotherapy for breast cancer—a systematic review. Support Care Cancer 24:3633–3650CrossRefPubMedGoogle Scholar
  14. 14.
    Fernandes R, Mazzarello S, Majeed H, Smith S, Shorr R, Hutton B, Ibrahim MF, Jacobs C, Ong M, Clemons M (2016) Treatment of taxane acute pain syndrome (TAPS) in cancer patients receiving taxane-based chemotherapy—a systematic review. Support Care Cancer 24:1583–1594CrossRefPubMedGoogle Scholar
  15. 15.
    Franke RM, Carducci MA, Rudek MA, Baker SD, Sparreboom A (2010) Castration-dependent pharmacokinetics of docetaxel in patients with prostate cancer. J Clin Oncol 28:4562–4567CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Fujiwara H, Urabe T, Ueda K, Mizunoe T, Date K, Nakano M, Honda N, Sakashita T, Fujito N (2000) Prevention of arthralgia and myalgia from paclitaxel and carboplatin combination chemotherapy with Shakuyaku-kanzo-to. Gan To Kagaku Ryoho 27:1061–1064PubMedGoogle Scholar
  17. 17.
    Gradishar WJ, Krasnojon D, Cheporov S, Makhson AN, Manikhas GM, Clawson A, Bhar P (2009) Significantly longer progression-free survival with nab-paclitaxel compared with docetaxel as first-line therapy for metastatic breast cancer. J Clin Oncol 27:3611–3619CrossRefPubMedGoogle Scholar
  18. 18.
    Imai A, Matsunami K, Takagi H, Ichigo S (2012) Proposed medications for taxane-induced myalgia and arthralgia (review). Oncol Lett 3:1181–1185CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Jacobs C, Hutton B, Mazzarello S, Smith S, Joy A, Amir E, Ibrahim MF, Gregario N, Daigle K, Eggert L, Clemons M (2015) Optimisation of steroid prophylaxis schedules in breast cancer patients receiving docetaxel chemotherapy—a survey of health care providers and patients. Support Care Cancer 23:3269–3275CrossRefPubMedGoogle Scholar
  20. 20.
    Jones SE, Savin MA, Holmes FA, O'Shaughnessy JA, Blum JL, Vukelja S, McIntyre KJ, Pippen JE, Bordelon JH, Kirby R, Sandbach J, Hyman WJ, Khandelwal P, Negron AG, Richards DA, Anthony SP, Mennel RG, Boehm KA, Meyer WG, Asmar L (2006) Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer. J Clin Oncol 24:5381–5387CrossRefPubMedGoogle Scholar
  21. 21.
    Kuchuk I, Beaumont JL, Clemons M, Amir E, Addison CL, Cella D (2013) Effects of de-escalated bisphosphonate therapy on the functional assessment of cancer therapy-bone pain, brief pain inventory and bone biomarkers. J Bone Oncol 2:154–157CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Lee JJ, Swain SM (2006) Peripheral neuropathy induced by microtubule-stabilizing agents. J Clin Oncol 24:1633–1642CrossRefPubMedGoogle Scholar
  23. 23.
    Loprinzi CL, Maddocks-Christianson K, Wolf SL, Rao RD, Dyck PJ, Mantyh P, Dyck PJ (2007) The paclitaxel acute pain syndrome: sensitization of nociceptors as the putative mechanism. Cancer J 13:399–403CrossRefPubMedGoogle Scholar
  24. 24.
    Loprinzi CL, Reeves BN, Dakhil SR, Sloan JA, Wolf SL, Burger KN, Kamal A, Le-Lindqwister NA, Soori GS, Jaslowski AJ, Novotny PJ, Lachance DH (2011) Natural history of paclitaxel-associated acute pain syndrome: prospective cohort study NCCTG N08C1. J Clin Oncol 29:1472–1478CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Mamounas EP, Bryant J, Lembersky B, Fehrenbacher L, Sedlacek SM, Fisher B, Wickerham DL, Yothers G, Soran A, Wolmark N (2005) Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28. J Clin Oncol 23:3686–3696CrossRefPubMedGoogle Scholar
  26. 26.
    Markman M, Kennedy A, Webster K, Kulp B, Peterson G, Belinson J (1999) Use of low-dose oral prednisone to prevent paclitaxel-induced arthralgias and myalgias. Gynecol Oncol 72:100–101CrossRefPubMedGoogle Scholar
  27. 27.
    Martin M, Pienkowski T, Mackey J, Pawlicki M, Guastalla JP, Weaver C, Tomiak E, Al-Tweigeri T, Chap L, Juhos E, Guevin R, Howell A, Fornander T, Hainsworth J, Coleman R, Vinholes J, Modiano M, Pinter T, Tang SC, Colwell B, Prady C, Provencher L, Walde D, Rodriguez-Lescure A, Hugh J, Loret C, Rupin M, Blitz S, Jacobs P, Murawsky M, Riva A, Vogel C, Breast Cancer International Research Group I (2005) Adjuvant docetaxel for node-positive breast cancer. N Engl J Med 352:2302–2313CrossRefPubMedGoogle Scholar
  28. 28.
    Martoni A, Zamagni C, Gheka A, Pannuti F (1993) Antihistamines in the treatment of taxol-induced paroxystic pain syndrome. J Natl Cancer Inst 85:676–677CrossRefPubMedGoogle Scholar
  29. 29.
    Michaud LB, Valero V, Hortobagyi G (2000) Risks and benefits of taxanes in breast and ovarian cancer. Drug Saf 23:401–428CrossRefPubMedGoogle Scholar
  30. 30.
    Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, Nishiwaki Y, Ohe Y, Yang JJ, Chewaskulyong B, Jiang H, Duffield EL, Watkins CL, Armour AA, Fukuoka M (2009) Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361:947–957CrossRefPubMedGoogle Scholar
  31. 31.
    Pignata S, Scambia G, Katsaros D, Gallo C, Pujade-Lauraine E, De Placido S, Bologna A, Weber B, Raspagliesi F, Panici PB, Cormio G, Sorio R, Cavazzini MG, Ferrandina G, Breda E, Murgia V, Sacco C, Cinieri S, Salutari V, Ricci C, Pisano C, Greggi S, Lauria R, Lorusso D, Marchetti C, Selvaggi L, Signoriello S, Piccirillo MC, Di Maio M, Perrone F, Multicentre Italian Trials in Ovarian c, Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens et du s, Mario Negri Gynecologic O, European Network of Gynaecological Oncological Trial G, Gynecologic Cancer InterGroup I (2014) Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): a randomised, multicentre, open-label, phase 3 trial. Lancet Oncol 15:396–405CrossRefPubMedGoogle Scholar
  32. 32.
    Portenoy RK, Thaler HT, Kornblith AB, Lepore JM, Friedlander-Klar H, Kiyasu E, Sobel K, Coyle N, Kemeny N, Norton L et al (1994) The memorial symptom assessment scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer 30A:1326–1336CrossRefPubMedGoogle Scholar
  33. 33.
    Reeves BN, Dakhil SR, Sloan JA, Wolf SL, Burger KN, Kamal A, Le-Lindqwister NA, Soori GS, Jaslowski AJ, Kelaghan J, Novotny PJ, Lachance DH, Loprinzi CL (2012) Further data supporting that paclitaxel-associated acute pain syndrome is associated with development of peripheral neuropathy: north central cancer treatment group trial N08C1. Cancer 118:5171–5178CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Rivera E, Mejia JA, Arun BK, Adinin RB, Walters RS, Brewster A, Broglio KR, Yin G, Esmaeli B, Hortobagyi GN, Valero V (2008) Phase 3 study comparing the use of docetaxel on an every-3-week versus weekly schedule in the treatment of metastatic breast cancer. Cancer 112:1455–1461CrossRefPubMedGoogle Scholar
  35. 35.
    Roche H, Fumoleau P, Spielmann M, Canon JL, Delozier T, Serin D, Symann M, Kerbrat P, Soulie P, Eichler F, Viens P, Monnier A, Vindevoghel A, Campone M, Goudier MJ, Bonneterre J, Ferrero JM, Martin AL, Geneve J, Asselain B (2006) Sequential adjuvant epirubicin-based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 trial. J Clin Oncol 24:5664–5671CrossRefPubMedGoogle Scholar
  36. 36.
    Saibil S, Fitzgerald B, Freedman OC, Amir E, Napolskikh J, Salvo N, Dranitsaris G, Clemons M (2010) Incidence of taxane-induced pain and distress in patients receiving chemotherapy for early-stage breast cancer: a retrospective, outcomes-based survey. Curr Oncol 17:42–47CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Sarris AH, Younes A, McLaughlin P, Moore D, Hagemeister F, Swan F, Rodriguez MA, Romaguera J, North L, Mansfield P, Callendar D, Mesina O, Cabanillas F (1996) Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin’s lymphoma. J Clin Oncol 14:233–239CrossRefPubMedGoogle Scholar
  38. 38.
    Smith RE, Anderson SJ, Brown A, Scholnik AP, Desai AM, Kardinal CG, Lembersky BC, Mamounas EP (2002) Phase II trial of doxorubicin/docetaxel/cyclophosphamide for locally advanced and metastatic breast cancer: results from NSABP trial BP-58. Clin Breast Cancer 3:333–340CrossRefPubMedGoogle Scholar
  39. 39.
    Strasser F, Demmer R, Bohme C, Schmitz SF, Thuerlimann B, Cerny T, Gillessen S (2008) Prevention of docetaxel- or paclitaxel-associated taste alterations in cancer patients with oral glutamine: a randomized, placebo-controlled, double-blind study. Oncologist 13:337–346CrossRefPubMedGoogle Scholar
  40. 40.
    Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN, Oudard S, Theodore C, James ND, Turesson I, Rosenthal MA, Eisenberger MA, Investigators TAX (2004) Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 351:1502–1512CrossRefPubMedGoogle Scholar
  41. 41.
    van Deventer H, Bernard S (1999) Use of gabapentin to treat taxane-induced myalgias. J Clin Oncol 17:434–435CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • R. Fernandes
    • 1
  • S. Mazzarello
    • 2
  • A. A. Joy
    • 3
  • G. R. Pond
    • 4
  • J. Hilton
    • 1
    • 2
  • M. F. K. Ibrahim
    • 1
  • C. Canil
    • 1
    • 2
  • M. Ong
    • 1
    • 2
  • C. Stober
    • 1
  • L. Vandermeer
    • 2
  • B. Hutton
    • 2
    • 5
  • M. da Costa
    • 1
  • S. Damaraju
    • 6
  • Mark Clemons
    • 1
    • 2
    • 7
  1. 1.Department of Medicine, Division of Medical OncologyThe Ottawa Hospital and University of OttawaOttawaCanada
  2. 2.Ottawa Hospital Research Institute and University of OttawaOttawaCanada
  3. 3.Department of Oncology, Division of Medical Oncology, Cross Cancer InstituteUniversity of AlbertaEdmontonCanada
  4. 4.McMaster University and Ontario Clinical Oncology GroupHamiltonCanada
  5. 5.Department of Epidemiology and Community MedicineUniversity of OttawaOttawaCanada
  6. 6.Department of Laboratory Medicine and PathologyUniversity of AlbertaEdmontonCanada
  7. 7.The Ottawa Hospital Cancer CentreOttawaCanada

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