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Supportive Care in Cancer

, Volume 26, Issue 2, pp 375–391 | Cite as

A systematic review of integrative clinical trials for supportive care in pediatric oncology: a report from the International Society of Pediatric Oncology, T&CM collaborative

  • Andrea L. Radossi
  • Katherine Taromina
  • Stacey Marjerrison
  • Caroline J. Diorio
  • Raquel Similio
  • Festus Njuguna
  • Glenn M. Afungchwi
  • Elena J. LadasEmail author
Review Article

Abstract

Purpose

Traditional and complementary medicine (T&CM) use in children with cancer is well established among high-income, upper middle-income, low-middle-income, and low-income countries (HIC, UMIC, LMIC, LIC, respectively). In HIC, a developing body of evidence exists for several T&CM therapies; however, evidence in other income settings is less well described despite a significantly higher use when compared to reports from HIC. The aim of this systematic review was to evaluate the evidence for T&CM for a variety of supportive care indications among children with cancer.

Methods

We performed a systematic review following the PRISMA guidelines of randomized, controlled clinical trials from inception through September 2016. Our eligibility criteria were limited to T&CM studies performed in children and adolescents undergoing treatment for a pediatric malignancy.

Results

Of 6342 studies identified, 44 met inclusion criteria. Two clinical trials reported on acupuncture, 1 reported on aromatherapy, 9 evaluated massage therapy, and 32 reported on dietary supplements. Twenty-two studies were performed in HIC, 15 in UMIC, and 7 in LMIC. T&CM therapies were most commonly investigated for the prevention or management of mucositis, weight loss, and febrile neutropenia. Encouraging results were reported for select interventions; however, the majority of studies were classified as poor to fair quality.

Conclusion

Our search revealed numerous clinical studies investigating the use of T&CM for supportive care purposes in pediatric oncology in HIC, UMIC, and LMIC. Although limited, these results could inform supportive care resource allocation and indicate where T&CM may serve to fill gaps where access to care may be limited.

Keywords

Traditional and complementary medicine Integrative medicine Pediatric oncology Supportive care Symptom management 

Notes

Acknowledgements

We would like to thank our research librarian, Louise Falzon, for the conduct of literature searches and Xiaoyu Lin, MS, for assistance in screening Chinese papers and contacting Chinese authors.

Funding information

Tamarind Foundation (EJL), American Cancer Society, Mentored Research Scholar Grant (127000-MRSG-14-157-01-CCE) (EJL), Hamilton Health Sciences New Investigator Fund (SM).

Supplementary material

520_2017_3908_MOESM1_ESM.docx (48 kb)
ESM 1 (DOCX 47 kb)

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Andrea L. Radossi
    • 1
  • Katherine Taromina
    • 1
  • Stacey Marjerrison
    • 2
  • Caroline J. Diorio
    • 2
  • Raquel Similio
    • 1
  • Festus Njuguna
    • 3
  • Glenn M. Afungchwi
    • 4
  • Elena J. Ladas
    • 5
    Email author
  1. 1.Division of Pediatric Hematology/Oncology/Stem Cell TransplantColumbia University Medical CenterNew YorkUSA
  2. 2.Division of Hematology and Oncology, Department of PediatricsMcMaster UniversityHamiltonCanada
  3. 3.Department of Child Health and PediatricsMoi UniversityEldoretKenya
  4. 4.Banso Baptist HospitalKumboCameroon
  5. 5.Division of Pediatric Hematology/Oncology/Stem Cell TransplantColumbia University Medical CenterNew YorkUSA

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