Supportive Care in Cancer

, Volume 26, Issue 2, pp 375–391 | Cite as

A systematic review of integrative clinical trials for supportive care in pediatric oncology: a report from the International Society of Pediatric Oncology, T&CM collaborative

  • Andrea L. Radossi
  • Katherine Taromina
  • Stacey Marjerrison
  • Caroline J. Diorio
  • Raquel Similio
  • Festus Njuguna
  • Glenn M. Afungchwi
  • Elena J. LadasEmail author
Review Article



Traditional and complementary medicine (T&CM) use in children with cancer is well established among high-income, upper middle-income, low-middle-income, and low-income countries (HIC, UMIC, LMIC, LIC, respectively). In HIC, a developing body of evidence exists for several T&CM therapies; however, evidence in other income settings is less well described despite a significantly higher use when compared to reports from HIC. The aim of this systematic review was to evaluate the evidence for T&CM for a variety of supportive care indications among children with cancer.


We performed a systematic review following the PRISMA guidelines of randomized, controlled clinical trials from inception through September 2016. Our eligibility criteria were limited to T&CM studies performed in children and adolescents undergoing treatment for a pediatric malignancy.


Of 6342 studies identified, 44 met inclusion criteria. Two clinical trials reported on acupuncture, 1 reported on aromatherapy, 9 evaluated massage therapy, and 32 reported on dietary supplements. Twenty-two studies were performed in HIC, 15 in UMIC, and 7 in LMIC. T&CM therapies were most commonly investigated for the prevention or management of mucositis, weight loss, and febrile neutropenia. Encouraging results were reported for select interventions; however, the majority of studies were classified as poor to fair quality.


Our search revealed numerous clinical studies investigating the use of T&CM for supportive care purposes in pediatric oncology in HIC, UMIC, and LMIC. Although limited, these results could inform supportive care resource allocation and indicate where T&CM may serve to fill gaps where access to care may be limited.


Traditional and complementary medicine Integrative medicine Pediatric oncology Supportive care Symptom management 



We would like to thank our research librarian, Louise Falzon, for the conduct of literature searches and Xiaoyu Lin, MS, for assistance in screening Chinese papers and contacting Chinese authors.

Funding information

Tamarind Foundation (EJL), American Cancer Society, Mentored Research Scholar Grant (127000-MRSG-14-157-01-CCE) (EJL), Hamilton Health Sciences New Investigator Fund (SM).

Supplementary material

520_2017_3908_MOESM1_ESM.docx (48 kb)
ESM 1 (DOCX 47 kb)


  1. 1.
    American Cancer Society (2015) Global Cancer Facts & Figures, 3rd edn. Accessed 4 Nov 2016
  2. 2.
    Bishop FL, Prescott P, Chan YK, Saville J, von Elm E, Lewith GT (2010) Prevalence of complementary medicine use in pediatric cancer: a systematic review. Pediatrics 125(4):768–776. CrossRefPubMedGoogle Scholar
  3. 3.
    Diorio C, Lam CG, Ladas EJ, Njuguna F, Mbah G, Taromina K, Marjerrison S (2016) Global use of traditional and complementary medicine in childhood cancer: a systematic review. J Glob Oncol.
  4. 4.
    Broom A, Nayar K, Tovey P, Shirali R, Thakur R, Seth T, Chhetri P (2009) Indian cancer patients’ use of traditional, complementary and alternative medicine (TCAM) and delays in presentation to hospital. Oman Med J 24(2):99–102. PubMedPubMedCentralGoogle Scholar
  5. 5.
    Handayani K, Sitaresmi MN, Supriyadi E, Widjajanto PH, Susilawati D, Njuguna F, van de Ven PM, Kaspers GJ, Mostert S (2016) Delays in diagnosis and treatment of childhood cancer in Indonesia. Pediatr Blood Cancer 63(12):2189–2196. CrossRefPubMedGoogle Scholar
  6. 6.
    Hord JD, Rehman W, Hannon P, Anderson-Shaw L, Schmidt ML (2006) Do parents have the right to refuse standard treatment for their child with favorable-prognosis cancer? Ethical and legal concerns. J Clin Oncol Off J Am Soc Clin Oncol 24(34):5454–5456. CrossRefGoogle Scholar
  7. 7.
    Borker A, Chaudhary N (2012) Pattern of refusal to treat and abandonment in a new pediatric oncology unit in southern India. Pediatr Blood Cancer 59(6):1100Google Scholar
  8. 8.
    World Health Organization (2013) World Health Organization traditional medicine strategy: 2014-2023. Accessed 4 Nov 2016
  9. 9.
    Makundi EA, Malebo HM, Mhame P, Kitua AY, Warsame M (2006) Role of traditional healers in the management of severe malaria among children below five years of age: the case of Kilosa and Handeni Districts, Tanzania. Malar J 5:58. CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    World Health Organization (2012) World Health Organization position statement: effectiveness of non-pharmaceutical forms of Artemisia annua L. against malaria. Accessed 4 Nov 2016
  11. 11.
    Peltzer K, Friend-du Preez N, Ramlagan S, Fomundam H, Anderson J (2010) Traditional complementary and alternative medicine and antiretroviral treatment adherence among HIV patients in Kwazulu-Natal, South Africa. Afr J Tradit Complement Altern Med 7(2):125–137Google Scholar
  12. 12.
    World Health Organization (1990) Report of the consultation on AIDS and traditional medicine: prospects for involving traditional health practitioners. Accessed 4 Nov 2016
  13. 13.
    Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA (2015) Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. Syst Rev 4:1. CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    The World Bank World Bank Country and Lending Groups. Accessed 4 Nov 2016
  15. 15.
    NIH: National Heart, Lung, and Blood Institute Quality assessment tool for controlled intervention studies. Accessed 4 Nov 2016
  16. 16.
    Hariohm K, Prakash V, Saravankumar J (2015) Quantity and quality of randomized controlled trials published by Indian physiotherapists. Perspect Clin Res 6(2):91–97. CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Gartlehner G, Hansen RA, Reichenpfader U, Kaminski A, Kien C, Strobelberger M, Van Noord M, Thieda P, Thaler K, Gaynes B (2011) Drug class review: second-generation antidepressants: final update 5 report. Oregon Health & Science University, PortlandGoogle Scholar
  18. 18.
    Nozaki T, Kusuzaki K, Takeshita H, Nakamura S, Hashiguchi S, Murata H, Hirasawa Y (2001) Effectiveness of activated vitamin D3 on improving prognosis of osteosarcoma patients. Oncol Rep 8(2):321–324PubMedGoogle Scholar
  19. 19.
    Abu Zaid Z, Shahar S, Jamal AR, Mohd Yusof NA (2012) Fish oil supplementation is beneficial on caloric intake, appetite and mid upper arm muscle circumference in children with leukaemia. Asia Pac J Clin Nutr 21(4):502–510PubMedGoogle Scholar
  20. 20.
    Gong JX, Meng JB, Ma Y (2012) Effects of all-trans retinoic acid and compound huangdai tablet sequential maintenance treatment on the long-term efficacy of acute promyelocytic leukemia patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 32(11):1473–1476PubMedGoogle Scholar
  21. 21.
    Shaban M, Rasoolzadeh N, Mehran A, Moradalizadeh F (2006) Study of two non-pharmacological methods, progressive muscle relaxation and music, on pain relief of cancerous patients. J Fac Nurs Midwifery 12(3):87Google Scholar
  22. 22.
    Tan D, Xie ZZ, Zhong M, Wu D, Liang X, Li W, Qin Q, Tam G (1997) Chinese herbal drugs: sheng-bai-kuai in the treatment of leukopenia caused by chemotherapy. Hunan Yi Ke Da Xue Xue Bao 22(6):547–549PubMedGoogle Scholar
  23. 23.
    Wei YF, Wang SY, Ren LL (2005) Efficacy of shenqi fuzheng injection combined with chemotherapy in treatment of acute leukemia and its effect on T-lymphocyte subsets, serum IFN-gamma, IL-10 and IL-2. Zhongguo Zhong Xi Yi Jie He Za Zhi 25(4):303–306PubMedGoogle Scholar
  24. 24.
    Yan Y (1995) Analysis of therapeutical effectiveness in 35 cases of acute leukemia with therapy of Chinese integrated medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi 15(11):643–645PubMedGoogle Scholar
  25. 25.
    Yang YF, Xu Y, Wu Y (2007) Clinical randomized double-blinded controlled study on Quxie Capsule in reducing post-operational relapse and metastasis of colorectal cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi 27(10):879–882PubMedGoogle Scholar
  26. 26.
    Zhu XY, Zhang XZ, Zhong XY (2010) Effect of shenqi fuzheng injection for hemopoietic and immune function reconstruction in patients with hematologic malignancies undergoing chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi 30(2):205–207PubMedGoogle Scholar
  27. 27.
    Chen QY, Xia JY, Han L (2010) Clinical study on treatment of acute radiation oral mucositis of yin deficiency-induced inner heat syndrome by nourishing yin and clearing heat method. Zhongguo Zhong Xi Yi Jie He Za Zhi 30(7):694–698PubMedGoogle Scholar
  28. 28.
    Fu J, Meng ZQ, Chen Z, Peng HT, Liu LM (2006) Clinical observation on electric stimulation of Yongquan (KI 1) for prevention of nausea and vomiting induced by Cisplatin. Zhongguo Zhen Jiu 26(4):250–252PubMedGoogle Scholar
  29. 29.
    Guo XM, Li JX, Yang XF (1997) Clinical observation on 112 cases with non-Hodgkin’s lymphoma treated by Chinese herbs combined with chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi 17(6):325–327PubMedGoogle Scholar
  30. 30.
    Jiang CM, Pang MR, Gong LY (2001) Clinical observation on effect of chemotherapy combined with Chinese medicine in treating advanced tumor patients and on immunologic parameters. Zhongguo Zhong Xi Yi Jie He Za Zhi 21(12):885–887PubMedGoogle Scholar
  31. 31.
    Li HY, Qian LS, Feng SZ (1997) Clinical observation on treatment of complications with Chinese medicine according to syndrome differentiation of post-bone marrow transplantation in 22 patients with leukemia. Zhongguo Zhong Xi Yi Jie He Za Zhi 17(10):581–583PubMedGoogle Scholar
  32. 32.
    RR X, Cao F, Liu ZX (2004) Clinical observation on treatment of acute myelocytic leukemia by supplementing qi, nourishing yin and clearing heat principle. Zhongguo Zhong Xi Yi Jie He Za Zhi 24(5):411–414Google Scholar
  33. 33.
    Wei YF, HL D, Wang SY (2003) Study on efficacy of treatment of acute leukemia by Shengfu injection in combination with chemotherapy and the effect on cellular immunity, serum interleukin-6 and tumor necrosis factor-alpha levels. Zhongguo Zhong Xi Yi Jie He Za Zhi 23(4):258–260PubMedGoogle Scholar
  34. 34.
    Abdulrhman M, Elbarbary NS, Ahmed Amin D, Saeid Ebrahim R (2012) Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatr Hematol Oncol 29(3):285–292. CrossRefPubMedGoogle Scholar
  35. 35.
    Bayram I, Erbey F, Celik N, Nelson JL, Tanyeli A (2009) The use of a protein and energy dense eicosapentaenoic acid containing supplement for malignancy-related weight loss in children. Pediatr Blood Cancer 52(5):571–574. CrossRefPubMedGoogle Scholar
  36. 36.
    El-Housseiny AA, Saleh SM, El-Masry AA, Allam AA (2007) The effectiveness of vitamin “E” in the treatment of oral mucositis in children receiving chemotherapy. J Clin Pediatr Dent 31(3):167–170CrossRefPubMedGoogle Scholar
  37. 37.
    Oberbaum M, Yaniv I, Ben-Gal Y, Stein J, Ben-Zvi N, Freedman LS, Branski D (2001) A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation. Cancer 92(3):684–690CrossRefPubMedGoogle Scholar
  38. 38.
    Abdulrhman MA, Hamed AA, Mohamed SA, Hassanen NA (2016) Effect of honey on febrile neutropenia in children with acute lymphoblastic leukemia: a randomized crossover open-labeled study. Complement Ther Med 25:98–103. CrossRefPubMedGoogle Scholar
  39. 39.
    Miladinia M, Baraz S, Nouri EM, Baesis MG (2015) Effects of slow-stroke back massage on chemotherapy-induced nausea and vomiting in the pediatrics with acute leukemia: a challenge of controlling symptoms. Int J Pediatr 3(6–2):1145–1152Google Scholar
  40. 40.
    Phipps S, Dunavant M, Gray E, Rai SN (2005) Massage therapy in children undergoing hematopoietic stem cell transplantation: results of a pilot trial. J Cancer Integr Med 3(2):62–70CrossRefGoogle Scholar
  41. 41.
    Elbarbary NS, Ismail EA, Farahat RK, El-Hamamsy M (2016) Omega-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: a randomized placebo-controlled study. Nutrition 32(1):41–47. CrossRefPubMedGoogle Scholar
  42. 42.
    Hagag AA, AbdElaal AM, Elfaragy MS, Hassan SM, Elzamarany EA (2015) Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia. Infect Disord Drug Targets 15(1):64–71CrossRefPubMedGoogle Scholar
  43. 43.
    Bradfield SM, Sandler E, Geller T, Tamura RN, Krischer JP (2015) Glutamic acid not beneficial for the prevention of vincristine neurotoxicity in children with cancer. Pediatr Blood Cancer 62(6):1004–1010. CrossRefPubMedGoogle Scholar
  44. 44.
    Mokhtar GM, Shaaban SY, Elbarbary NS, Fayed WA (2010) A trial to assess the efficacy of glutamic acid in prevention of vincristine-induced neurotoxicity in pediatric malignancies: a pilot study. J Pediatr Hematol Oncol 32(8):594–600. CrossRefPubMedGoogle Scholar
  45. 45.
    Wada M, Nagata S, Saito M, Shimizu T, Yamashiro Y, Matsuki T, Asahara T, Nomoto K (2010) Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies. Support Care Cancer 18(6):751–759. CrossRefPubMedGoogle Scholar
  46. 46.
    Rocha KC, Vieira ML, Beltrame RL, Cartum J, Alves SI, Azzalis LA, Junqueira VB, Pereira EC, Fonseca FL (2016) Impact of selenium supplementation in neutropenia and immunoglobulin production in childhood cancer patients. J Med Food 19(6):560–568. CrossRefPubMedGoogle Scholar
  47. 47.
    Reindl TK, Geilen W, Hartmann R, Wiebelitz KR, Kan G, Wilhelm I, Lugauer S, Behrens C, Weiberlenn T, Hasan C, Gottschling S, Wild-Bergner T, Henze G, Driever PH (2006) Acupuncture against chemotherapy-induced nausea and vomiting in pediatric oncology. Interim results of a multicenter crossover study. Support Care Cancer 14(2):172–176. CrossRefPubMedGoogle Scholar
  48. 48.
    Gottschling S, Reindl TK, Meyer S, Berrang J, Henze G, Graeber S, Ong MF, Graf N (2008) Acupuncture to alleviate chemotherapy-induced nausea and vomiting in pediatric oncology—a randomized multicenter crossover pilot trial. Klin Padiatr 220(6):365–370. CrossRefPubMedGoogle Scholar
  49. 49.
    Ndao DH, Ladas EJ, Cheng B, Sands SA, Snyder KT, Garvin JH Jr, Kelly KM (2012) Inhalation aromatherapy in children and adolescents undergoing stem cell infusion: results of a placebo-controlled double-blind trial. Psycho-Oncology 21(3):247–254. CrossRefPubMedGoogle Scholar
  50. 50.
    Mazlum S, Chaharsoughi NT, Banihashem A, Vashani HB (2013) The effect of massage therapy on chemotherapy-induced nausea and vomiting in pediatric cancer. Iran J Nurs Midwifery Res 18(4):280–284PubMedPubMedCentralGoogle Scholar
  51. 51.
    Batalha LM, Mota AA (2013) Massage in children with cancer: effectiveness of a protocol. J Pediatr 89(6):595–600. CrossRefGoogle Scholar
  52. 52.
    Phipps S, Barrera M, Vannatta K, Xiong X, Doyle JJ, Alderfer MA (2010) Complementary therapies for children undergoing stem cell transplantation: report of a multisite trial. Cancer 116(16):3924–3933. CrossRefPubMedPubMedCentralGoogle Scholar
  53. 53.
    Phipps S, Peasant C, Barrera M, Alderfer MA, Huang Q, Vannatta K (2012) Resilience in children undergoing stem cell transplantation: results of a complementary intervention trial. Pediatrics 129(3):e762–e770. CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Post-White J, Fitzgerald M, Savik K, Hooke MC, Hannahan AB, Sencer SF (2009) Massage therapy for children with cancer. J Pediatr Oncol Nurs 26(1):16–28. CrossRefPubMedGoogle Scholar
  55. 55.
    Haun JN, Graham-Pole J, Shortley B (2009) Children with cancer and blood diseases experience positive physical and psychological effects from massage therapy. Int J Ther Massage Bodyw 2(2):7–14Google Scholar
  56. 56.
    Field T, Cullen C, Diego M, Hernandez-Reif M, Sprinz P, Beebe K, Kissell B, Bango-Sanchez V (2001) Leukemia immune changes following massage therapy. J Bodyw Mov Ther.
  57. 57.
    Aquino VM, Harvey AR, Garvin JH, Godder KT, Nieder ML, Adams RH, Jackson GB, Sandler ES (2005) A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study. Bone Marrow Transplant 36(7):611–616. CrossRefPubMedGoogle Scholar
  58. 58.
    Khurana H, Pandey RK, Saksena AK, Kumar A (2013) An evaluation of vitamin E and pycnogenol in children suffering from oral mucositis during cancer chemotherapy. Oral Dis 19(5):456–464. CrossRefPubMedGoogle Scholar
  59. 59.
    Kokkonen J, Mottonen M, Karttunen TJ, Lanning M (2002) Mucosal pathology of the upper gastrointestinal tract associated with intensive chemotherapy in children: vitamin A supplements do not prevent lesions. Pediatr Hematol Oncol 19(3):181–192. CrossRefPubMedGoogle Scholar
  60. 60.
    Okur A, Ezgu FS, Tumer L, Cinasal G, Oguz A, Hasanoglu A, Karadeniz C (2006) Effects of oral glutamine supplementation on children with solid tumors receiving chemotherapy. Pediatr Hematol Oncol 23(4):277–285. CrossRefPubMedGoogle Scholar
  61. 61.
    Sencer SF, Zhou T, Freedman LS, Ives JA, Chen Z, Wall D, Nieder ML, Grupp SA, LC Y, Sahdev I, Jonas WB, Wallace JD, Oberbaum M (2012) Traumeel S in preventing and treating mucositis in young patients undergoing SCT: a report of the Children’s Oncology Group. Bone Marrow Transplant 47(11):1409–1414. CrossRefPubMedPubMedCentralGoogle Scholar
  62. 62.
    Tomazevic T, Jazbec J (2013) A double blind randomised placebo controlled study of propolis (bee glue) effectiveness in the treatment of severe oral mucositis in chemotherapy treated children. Complement Ther Med 21(4):306–312. CrossRefPubMedGoogle Scholar
  63. 63.
    Uderzo C, Rebora P, Marrocco E, Varotto S, Cichello F, Bonetti M, Maximova N, Zanon D, Fagioli F, Nesi F, Masetti R, Rovelli A, Rondelli R, Valsecchi MG, Cesaro S (2011) Glutamine-enriched nutrition does not reduce mucosal morbidity or complications after stem-cell transplantation for childhood malignancies: a prospective randomized study. Transplantation 91(12):1321–1325. CrossRefPubMedGoogle Scholar
  64. 64.
    Yildirim ZK, Bidev D, Buyukavci M (2013) Parenteral glutamine supplementation has no effect on chemotherapy-induced toxicity in children with non-Hodgkin lymphoma. J Pediatr Hematol Oncol 35(5):371–376. CrossRefPubMedGoogle Scholar
  65. 65.
    Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P, Ota S, Feldman BM (2007) Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients. Eur Jo Cancer 43(8):1269–1275. CrossRefGoogle Scholar
  66. 66.
    Tacyildiz N, Ozyoruk D, Yavuz G, Unal E, Dincaslan H, Dogu F, Sahin K, Kucuk O (2010) Soy isoflavones ameliorate the adverse effects of chemotherapy in children. Nutr Cancer 62(7):1001–1005. CrossRefPubMedGoogle Scholar
  67. 67.
    Shi X, Zhu XD, Wang HM (2012) Effects of fuzheng jianpi decoction combined chemotherapy on the quality of life and the survival time of children with solid tumor. Zhongguo Zhong Xi Yi Jie He Za Zhi 32(9):1175–1179PubMedGoogle Scholar
  68. 68.
    Shi X, Zhu XD, Wang HM (2007) Effect of supporting the healthy energy and strengthening Pi principle of TCM combined with chemotherapy in treating children with solid tumors. Zhongguo Zhong Xi Yi Jie He Za Zhi 27(6):542–545PubMedGoogle Scholar
  69. 69.
    Vieira ML, Fonseca FL, Costa LG, Beltrame RL, Chaves CM, Cartum J, Alves SI, Azzalis LA, Junqueira VB, Pereria EC, Rocha KC (2015) Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer. J Med Food 18(1):109–117. CrossRefPubMedGoogle Scholar
  70. 70.
    Consolo LZ, Melnikov P, Consolo FZ, Nascimento VA, Pontes JC (2013) Zinc supplementation in children and adolescents with acute leukemia. Eur J Clin Nutr 67(10):1056–1059. CrossRefPubMedGoogle Scholar
  71. 71.
    Naderi A, Doustan F, Shahabi Nejad A, Dehghani A, Hayatbakhsh Abbasi M (2014) Effects of dietary supplements of pediasure and carnitine on the anthropometric indices in children with acute lymphoblastic leukemia under chemotherapy, in Afzalipour Hospital, Kerman, Iran. J Kerman Univ Med Sci 21(4):332–342Google Scholar
  72. 72.
    Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, Kelly KM (2010) A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer 116(2):506–513. CrossRefPubMedPubMedCentralGoogle Scholar
  73. 73.
    Garami M, Schuler D, Babosa M, Borgulya G, Hauser P, Muller J, Paksy A, Szabo E, Hidvegi M, Fekete G (2004) Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients. J Pediatr Hematol Oncol 26(10):631–635CrossRefGoogle Scholar
  74. 74.
    Shi X, Liu Z-M, Zhu X-D (2012) Treatment of vomiting in children patients with solid tumor by hewei zhiou recipe combined ondansetron hydrochloride. Chin J Integr Tradit West Med 32(4):468–470Google Scholar
  75. 75.
    Pillai AK, Sharma KK, Gupta YK, Bakhshi S (2011) Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatr Blood Cancer 56(2):234–238. CrossRefPubMedGoogle Scholar
  76. 76.
    Diaz PR, Neira LC, Fischer SG, Teresa Torres MC, Milinarsky AT, Giadrosich VR, Arriagada MM, Arinoviche RS, Casanova DM (2008) Effect of 1,25(OH)2-vitamin D on bone mass in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol 30(1):15–19. CrossRefPubMedGoogle Scholar
  77. 77.
    Dagdemir A, Yildirim H, Aliyazicioglu Y, Kanber Y, Albayrak D, Acar S (2004) Does vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer? Support Care Cancer 12(4):263–267. CrossRefPubMedGoogle Scholar
  78. 78.
    Ladas EJ, Rivas S, Ndao D, Damoulakis D, Bao YY, Cheng B, Kelly KM, Antillon F (2014) Use of traditional and complementary/alternative medicine (TCAM) in children with cancer in Guatemala. Pediatr Blood Cancer 61(4):687–692. CrossRefPubMedGoogle Scholar
  79. 79.
    Kelly KM, Jacobson JS, Kennedy DD, Braudt SM, Mallick M, Weiner MA (2000) Use of unconventional therapies by children with cancer at an urban medical center. J Pediatr Hematol Oncol 22(5):412–416CrossRefPubMedGoogle Scholar
  80. 80.
    Hughes D, Ladas E, Rooney D, Kelly K (2008) Massage therapy as a supportive care intervention for children with cancer. Oncol Nurs Forum 35(3):431–442. CrossRefPubMedGoogle Scholar
  81. 81.
    Nahin RL, Boineau R, Khalsa PS, Stussman BJ, Weber WJ (2016) Evidence-based evaluation of complementary health approaches for pain management in the United States. Mayo Clin Proc 91(9):1292–1306. CrossRefPubMedPubMedCentralGoogle Scholar
  82. 82.
    Vickers AJ, Cronin AM, Maschino AC, Lewith G, MacPherson H, Foster NE, Sherman KJ, Witt CM, Linde K (2012) Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med 172(19):1444–1453. CrossRefPubMedPubMedCentralGoogle Scholar
  83. 83.
    Vickers AJ, Linde K (2014) Acupuncture for chronic pain. JAMA 311(9):955–956. CrossRefPubMedPubMedCentralGoogle Scholar
  84. 84.
    Berman BM, Langevin HM, Witt CM, Dubner R (2010) Acupuncture for chronic low back pain. N Engl J Med 363(5):454–461. CrossRefPubMedGoogle Scholar
  85. 85.
    Liu F, Han X, Li Y, Yu S (2016) Acupuncture in the treatment of tinnitus: a systematic review and meta-analysis. Eur Archo Otorhinolaryngol 273(2):285–294. CrossRefGoogle Scholar
  86. 86.
    Chiu HY, Hsieh YJ, Tsai PS (2016) Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a systematic review and meta-analysis. Obstet Gynecol 127(3):507–515. CrossRefPubMedGoogle Scholar
  87. 87.
    Garcia MK, McQuade J, Haddad R, Patel S, Lee R, Yang P, Palmer JL, Cohen L (2013) Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol Off J Am Soc Clin Oncol 31(7):952–960. CrossRefGoogle Scholar
  88. 88.
    Ladas EJ, Rooney D, Taromina K, Ndao DH, Kelly KM (2010) The safety of acupuncture in children and adolescents with cancer therapy-related thrombocytopenia. Support Care Cancer 18(11):1487–1490. CrossRefPubMedGoogle Scholar
  89. 89.
    Jindal V, Ge A, Mansky PJ (2008) Safety and efficacy of acupuncture in children: a review of the evidence. J Pediatr Hematol Oncol 30(6):431–442. CrossRefPubMedPubMedCentralGoogle Scholar
  90. 90.
    Chokshi SK, Ladas EJ, Taromina K, McDaniel D, Rooney D, Jin Z, Hsu WC, Kelly KM (2017) Predictors of acupuncture use among children and adolescents with cancer. Pediatr Blood Cancer.

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Andrea L. Radossi
    • 1
  • Katherine Taromina
    • 1
  • Stacey Marjerrison
    • 2
  • Caroline J. Diorio
    • 2
  • Raquel Similio
    • 1
  • Festus Njuguna
    • 3
  • Glenn M. Afungchwi
    • 4
  • Elena J. Ladas
    • 5
    Email author
  1. 1.Division of Pediatric Hematology/Oncology/Stem Cell TransplantColumbia University Medical CenterNew YorkUSA
  2. 2.Division of Hematology and Oncology, Department of PediatricsMcMaster UniversityHamiltonCanada
  3. 3.Department of Child Health and PediatricsMoi UniversityEldoretKenya
  4. 4.Banso Baptist HospitalKumboCameroon
  5. 5.Division of Pediatric Hematology/Oncology/Stem Cell TransplantColumbia University Medical CenterNew YorkUSA

Personalised recommendations