Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial
- 804 Downloads
Cancer-related fatigue (CRF) is a distressing symptom that is the most common unpleasant side effect experienced by lung cancer patients and is challenging for clinical care workers to manage.
We performed a randomized, double-blind, placebo-controlled pilot trial to evaluate the clinical effect of acupuncture on CRF in lung cancer patients. Twenty-eight patients presenting with CRF were randomly assigned to active acupuncture or placebo acupuncture groups to receive acupoint stimulation (LI-4, Ren-6, St-36, KI-3, and Sp-6) twice per week for 4 weeks, followed by 2 weeks of follow-up. The primary outcome was the change in intensity of CFR based on the Chinese version of the Brief Fatigue Inventory (BFI-C). As the secondary endpoint, the Functional Assessment of Cancer Therapy-Lung Cancer Subscale (FACT-LCS) was adopted to assess the influence of acupuncture on patients’ quality of life (QOL). Adverse events and safety of treatments were monitored throughout the trial.
Our pilot study demonstrated feasibility among patients with appropriate inclusion criteria and good compliance with acupuncture treatment. A significant reduction in the BFI-C score was observed at 2 weeks in the 14 participants who received active acupuncture compared with those receiving the placebo (P < 0.01). At week 6, symptoms further improved according to the BFI-C (P < 0.001) and the FACT-LCS (P = 0.002). There were no significant differences in the incidence of adverse events in either group (P > 0.05).
Fatigue is a common symptom experienced by lung cancer patients. Acupuncture may be a safe and feasible optional method for adjunctive treatment in cancer palliative care, and appropriately powered trials are warranted to evaluate the effects of acupuncture.
KeywordsAcupuncture Lung cancer Cancer-related fatigue Quality of life
The authors would like to thank Professor Zhiqiang Meng for his contributions to the organization of this study and his valuable advices. This study was supported by grants from the Comprehensive and Integrative Medicine Institute (CIMI) and the National Natural Science Foundation of China (No. 81403248).
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Written informed consent was obtained from all individual participants included in the study. All procedures performed in studies were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards and with the ethical standards of the Shanghai Cancer Center, Fudan University (ClinicalTrials.gov Identifier: NCT01881516).
- 2.Hoffman AJ, Brintnall RA, Brown JK, Eye A, Jones LW, Alderink G, Ritz-Holland D, Enter M, Patzelt LH, Vanotteren GM (2013) Too sick not to exercise: using a 6-week, home-based exercise intervention for cancer-related fatigue self-management for postsurgical non-small cell lung cancer patients. Cancer Nurs 36:175–188CrossRefPubMedGoogle Scholar
- 3.Iwase S, Kawaguchi T, Tokoro A, Yamada K, Kanai Y, Matsuda Y, Kashiwaya Y, Okuma K, Inada S, Ariyoshi K, Miyaji T, Azuma K, Ishiki H, Unezaki S, Yamaguchi T (2015) Assessment of cancer-related fatigue, pain, and quality of life in cancer patients at palliative care team referral: a multicenter observational study (JORTC PAL-09). PLoS One 10:e0134022CrossRefPubMedPubMedCentralGoogle Scholar
- 22.Johnston MF, Hays RD, Subramanian SK, Elashoff RM, Axe EK, Li JJ, Kim I, Vargas RB, Lee J, Yang L, Hui KK (2011) Patient education integrated with acupuncture for relief of cancer-related fatigue randomized controlled feasibility study. BMC Complement Altern Med 11:49CrossRefPubMedPubMedCentralGoogle Scholar
- 33.Kilian-Kita A, Puskulluoglu M, Konopka K, Krzemieniecki K (2016) Acupuncture: could it become everyday practice in oncology? Contemp Oncol (Pozn) 20:119–123Google Scholar